BrainRegionFEC FT SNR MED

Substantia Nigra Pars Reticulata Medial

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This page covers biological details of component Substantia Nigra Pars Reticulata Medial. Region is part of aHuman target integrated biological model.

• Top-down path to region: Forebrain Telencephalon -> Basal Ganglia (FEC.FT.BG) -> Substantia Nigra (FEC.FT.SN) -> Substantia Nigra Pars Reticulata (FEC.FT.SNR) -> Substantia Nigra Pars Reticulata Medial (FEC.FT.SNR.MED) (see Mind Maps)
• Type: nucleus
• Quality: L0
• Brain area: Forebrain - Execution Control Area
• Role: basal.ganglia.nigrareticulata
• Function: Motivational loop

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Components

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• no child items defined

Connectivity

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Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Reference
FEC	FEC.FD.STN.DL	Subthalamic Nucleus Dorsolateral	excitatory-glu	(unknown reference)
	FEC.FT.ACC.CORE	Nucleus Accumbens Core	inhibitory-gaba	Craving (NACC -> SNr, abstract)
	FEC.FT.CN.TL	Caudate Nucleus Tail	inhibitory-gaba	Saccades and smooth movements (CN -> SN, abstract)
	FEC.FT.GPE.RM	Globus Pallidus External Rostromedial	inhibitory-gaba	Prefrontal Cortex (PFC) in motor behavior (GP -> SN, abstract)
	FEC.FT.PU.VT	Ventral Putamen	inhibitory-gaba	(unknown reference)
	FEC.FT.VP.DL	Ventral Pallidum Dorsolateral	inhibitory-gaba	Craving (VPAL -> SNr, abstract)
NDM	NDM.NC.AL.FPC	Lateral Frontopolar Cortex	excitatory-glu	Global visual system (FrontalCortex -> BGA, abstract)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Reference
FEC	FEC.FT.SNC.MED	Substantia Nigra Pars Compacta Medial	inhibitory-gaba	(unknown reference)
	FEC.HT.TG.IPD	Interpeduncular Nucleus	inhibitory-gaba	(unknown reference)
NMA	NMA.FD.TH.MDL	Lateral Mediodorsal Nucleus of Thalamus	inhibitory-gaba	Saccadic Vision (BG -> Thalamus, abstract)

Thirdparty Circuits

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• Saccadic Vision - see Reference (CP.SACCADIC-VISION)

BG=Basal Ganglia,FEC.FT.BG
CN=Caudate Nucleus,FEC.FT.CN (see Basal Ganglia)
CR=Cerebellum,LLC.HT.CR (see Cerebellar Complex)
FrontalCortex=Anterior Lobe,NC.LOBE.ANT
GPe=Globus Pallidus External,FEC.FT.GPE (see Basal Ganglia)
LGN=Lateral Geniculate Nucleus,NSA.FD.LGN
LIP=Lateral Intraparietal Sulcus,NPE.NC.IPS.LIP
RF=Pontine Reticular Formation,HT.RF
Retina=Retinal Nucleus,LPC.FD.RT
SCi=Superior Colliculus,MM.SC (see Reflexes Nuclei of Midbrain Mesencephalon)
SCs=Superior Colliculus,MM.SC (see Reflexes Nuclei of Midbrain Mesencephalon)
SNpr=Substantia Nigra Pars Reticulata Dorsolateral,FEC.FT.SNR.DL
STN=Subthalamic Nucleus,FEC.FD.STN (see Subthalamus Area)
Thalamus=Thalamus,FD.TH
VisualCortex=Occipital Lobe,NC.LOBE.OCC

• Craving - see Reference (CF.CRAVING)

NACC=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia)
OMPFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
SNr=Substantia Nigra Pars Reticulata Medial,FEC.FT.SNR.MED
VPAL=Ventral Pallidum,FEC.FT.VP (see Basal Ganglia)
VTA=Ventral Tegmental Area,LMC.MM.VTA

References

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• http://www.nature.com/nrn/journal/v5/n3/box/nrn1345_BX1.html
• http://www.impulsecontroldisorders.org/html/cravings.html