Proximal Subiculum

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This page covers biological details of component Proximal Subiculum. Region is part of aHuman target integrated biological model.

Top-down path to region: Forebrain Telencephalon -> Hippocampal Formation (FMM.FT.HF) -> Subiculum (FMM.FT.HF.SUB) -> Proximal Subiculum (FMM.FT.HF.SUBP) (see Mind Maps)
Type: cortex
Brain area: Forebrain - Memory Management Area
Role: processor.memory.sub
Function: Controlling hypothalamic-pituitary-adrenal (HPA) axis

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Components

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Connectivity

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FMM.FT.HF.SUBP.dot.png

Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Reference
FAM	FAM.FT.SEP.BAC	Bed Nucleus of Anterior Commissure	excitatory-glu	Medial mammillary nucleus and theta rhythm (SEP -> HF, abstract)
FMM	FMM.FD.TH.RH	Rhomboidal Nucleus of Thalamus	excitatory-glu	Contributions of Diencephalon to Recognition Memory (MID -> SubPrePara, abstract)
	FMM.FT.HC.CA1D	Distal CA1 of Hippocampus	excitatory-glu	Attractor Network in Hippocampus (CA1 -> SUB, abstract)
	FMM.NC.PH.LEC	Lateral Entorhinal Cortex	excitatory-glu	Visual Path to Hippocampus (ER -> H, abstract)
	FMM.NC.PH.PER	Perirhinal Cortex	excitatory-glu	Gustatory sensory system of rat and macaque (PrC -> HF, abstract)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Reference
FAM	FAM.FT.AM.AB	Accessory Basal Amygdaloid Nucleus	excitatory-glu	Simplified model of hippocampal formation anatomy (SUB -> Amyg, abstract)
FEC	FEC.FT.ACC.CORE	Nucleus Accumbens Core	excitatory-glu	Nucleus Accumbens (SUB -> NACC, abstract)
FMM	FMM.FD.MB.MMB	Medial Mammillary Nucleus	excitatory-glu	Principal Connections of Hippocampus (HC -> MB, abstract)
LAC	LAC.FD.HT.AH	Anterior Hypothalamic Nucleus	excitatory-glu	(unknown reference)
	LAC.FD.HT.VM	Ventromedial Hypothalamic Nucleus	excitatory-glu	(unknown reference)

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map: Amyg=Amygdala,FAM.FT.AM, CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P), Middle CA1 of Hippocampus (FMM.FT.HC.CA1M), Distal CA1 of Hippocampus (FMM.FT.HC.CA1D)), CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P), Middle CA3 of Hippocampus (FMM.FT.HC.CA3M), Distal CA3 of Hippocampus (FMM.FT.HC.CA3D)), DG=Dentate Gyrus,FMM.FT.HC.DG, EC=Entorhinal Cortex,FMM.NC.PH.ET (Lateral Entorhinal Cortex (FMM.NC.PH.LEC), Medial Entorhinal Cortex (FMM.NC.PH.MEC)), NACC=Accumbens Nucleus,FEC.FT.ACC (Nucleus Accumbens Core (FEC.FT.ACC.CORE), Nucleus Accumbens Shell (FEC.FT.ACC.SH)), SUB=Subiculum,FMM.FT.HF.SUB (Proximal Subiculum (FMM.FT.HF.SUBP), Middle Subiculum (FMM.FT.HF.SUBM), Distal Subiculum (FMM.FT.HF.SUBD)), mPFC=Orbitofrontal Cortex,NC.AL.OPFC (Lateral Frontopolar Cortex (NDM.NC.AL.FPC), Most Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCR), Sulcal Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCS), Medial Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCM), Lateral Rostral Orbitofrontal Cortex (NDM.NC.AL.ROFCL)) unavailable

map: AM=Amygdala,FAM.FT.AM, AN=Anterior Nucleus of Thalamus,FD.TH.AN (Anteromedial Nucleus (NCP.FD.TH.AM), Anteroventral Nucleus (FMM.FD.TH.AV), Anterodorsal Nucleus (FMM.FD.TH.AD)), DG=Dentate Gyrus,FMM.FT.HC.DG, DorsalCingulate=Dorsal Anterior Cingulate Area,NDM.NC.AL.DACG, EC=Entorhinal Cortex,FMM.NC.PH.ET (Lateral Entorhinal Cortex (FMM.NC.PH.LEC), Medial Entorhinal Cortex (FMM.NC.PH.MEC)), HC=Subiculum,FMM.FT.HF.SUB (Proximal Subiculum (FMM.FT.HF.SUBP), Middle Subiculum (FMM.FT.HF.SUBM), Distal Subiculum (FMM.FT.HF.SUBD)), MB=Medial Mammillary Nucleus,FMM.FD.MB.MMB, PosteriorCingulate=Posterior Cingulate Cortex,NCP.NC.MPL.PSCG, SEP=Septal Nuclei,FAM.FT.SEP, SUB=Subiculum,FMM.FT.HF.SUB (Proximal Subiculum (FMM.FT.HF.SUBP), Middle Subiculum (FMM.FT.HF.SUBM), Distal Subiculum (FMM.FT.HF.SUBD)), VentralCingulate=Ventral Anterior Cingulate Area,NDM.NC.AL.VACG unavailable

map: AN=Anterior Nucleus of Thalamus,FD.TH.AN (Anteromedial Nucleus (NCP.FD.TH.AM), Anteroventral Nucleus (FMM.FD.TH.AV), Anterodorsal Nucleus (FMM.FD.TH.AD)), CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P), Middle CA1 of Hippocampus (FMM.FT.HC.CA1M), Distal CA1 of Hippocampus (FMM.FT.HC.CA1D)), CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P), Middle CA3 of Hippocampus (FMM.FT.HC.CA3M), Distal CA3 of Hippocampus (FMM.FT.HC.CA3D)), DG=Dentate Gyrus,FMM.FT.HC.DG, EC=Entorhinal Cortex,FMM.NC.PH.ET (Lateral Entorhinal Cortex (FMM.NC.PH.LEC), Medial Entorhinal Cortex (FMM.NC.PH.MEC)), MBIN=Medial Mammillary Nucleus,FMM.FD.MB.MMB, MBOUT=Lateral Mammillary Nucleus,FMM.FD.MB.LMB, NACC=Accumbens Nucleus,FEC.FT.ACC (Nucleus Accumbens Core (FEC.FT.ACC.CORE), Nucleus Accumbens Shell (FEC.FT.ACC.SH)), PERI=Perirhinal Cortex,FMM.NC.PH.PER, PRESUB=Presubiculum,FMM.NC.PH.PRS, SEP=Septal Nuclei,FAM.FT.SEP, SUB=Subiculum,FMM.FT.HF.SUB (Proximal Subiculum (FMM.FT.HF.SUBP), Middle Subiculum (FMM.FT.HF.SUBM), Distal Subiculum (FMM.FT.HF.SUBD)) unavailable

map: CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P), Middle CA1 of Hippocampus (FMM.FT.HC.CA1M), Distal CA1 of Hippocampus (FMM.FT.HC.CA1D)), CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P), Middle CA3 of Hippocampus (FMM.FT.HC.CA3M), Distal CA3 of Hippocampus (FMM.FT.HC.CA3D)), EC=Entorhinal Cortex,FMM.NC.PH.ET (Lateral Entorhinal Cortex (FMM.NC.PH.LEC), Medial Entorhinal Cortex (FMM.NC.PH.MEC)), NACC=Accumbens Nucleus,FEC.FT.ACC (Nucleus Accumbens Core (FEC.FT.ACC.CORE), Nucleus Accumbens Shell (FEC.FT.ACC.SH)), PAS=Parasubiculum,FMM.NC.PH.PAS, PRR=Perirhinal Cortex,FMM.NC.PH.PER, SUB=Subiculum,FMM.FT.HF.SUB (Proximal Subiculum (FMM.FT.HF.SUBP), Middle Subiculum (FMM.FT.HF.SUBM), Distal Subiculum (FMM.FT.HF.SUBD)) unavailable

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