BrainAreaFAM

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Forebrain Affective Motivations Area

Home -> BiologicalLifeResearch -> BrainAreaFAM


Local Circuits

(generated)

ID Name Regions
FAMXAA Acquisition of Avoidance Responses FAM.FD.LHB.LT, FAM.FD.LHB.MED
FAMXCEC Conscious Emotions Control FAM.FT.AM.BP, FAM.FT.AM.ITC, FAM.FT.SEP.SF, FAM.FT.SEP.TR
FAMXCS Conditional Context Sensory Data and Memory Attention FAM.FD.TH.PT, FAM.FT.AM.AB, FAM.FT.AM.BM, FAM.FT.AM.COA, FAM.FT.AM.LADL
FAMXEFL Express Flight Emotions FAM.FT.AM.MEA, FAM.FT.AM.MPD, FAM.FT.AM.MPV, FAM.FT.BNST, FAM.FT.IPAC.MED, FAM.FT.SEP.BAC
FAMXEFT Express Fight Emotions FAM.FT.AM.CEM, FAM.FT.SEP.SH
FAMXFFD Solving Fight-Flight Dilemma FAM.FT.SEP.LT
FAMXMF Memory Formation Affective Focus FAM.FT.SEP.DBB, FAM.FT.SEP.MED
FAMXREC Reward Emotions Control FAM.FD.MHB, FAM.FT.EPF, FAM.HT.TG.NI
FAMXUS Fast Unconditional Sensory Data and Association Memory FAM.FT.AM.CEC, FAM.FT.AM.CEL, FAM.FT.AM.COP, FAM.FT.AM.LAVL, FAM.FT.AM.LAVM

Acquisition of Avoidance Responses

unavailable

Component ID Component Name Type Service Function Comments
FAM.FD.LHB.LT Lateral Habenula Lateral Part nucleus FAU Encoding negative feedback, direct, Pallidal
FAM.FD.LHB.MED Lateral Habenula Medial Part nucleus FAU Encoding negative feedback, direct, Septal

Internal Region Connections:

  • no connections

External Inbound Region Connections:

Source Area Local Region Source Region Source Name Type Reference
Subcortical
FAM FAM.FD.LHB.LT FAM.FT.EPF Endopiriform Nucleus nucleus-nucleus Regulation of the rapid eye movement (REM) sleep by habenular projection (EPN -> LHbL)
FAM.FD.LHB.MED FAM.FD.MHB Medial Habenula nucleus-nucleus Connectivity map of the habenula (M -> L, abstract)
FAM.FT.SEP.DBB Diagonal Band of Broca nucleus-nucleus-gaba Both LHb and MHb control the dopaminergic and serotonergic systems (DBB -> LHbM)
FAM.FT.SEP.LT Lateral Septal Nucleus nucleus-nucleus-gaba Both LHb and MHb control the dopaminergic and serotonergic systems (LS -> LHbM)
FEC FAM.FD.LHB.LT FEC.FT.ACC.CORE Nucleus Accumbens Core nucleus-nucleus-gaba Connectivity map of the habenula (NAc -> L, abstract)
FEC.FT.GPI.DS Globus Pallidus Internal Dorsal nucleus-nucleus-gaba Habenula Connections (GPi -> LHb, abstract)
FAM.FD.LHB.MED FEC.FT.VP.VM Ventral Pallidum Ventromedial nucleus-nucleus-gaba Both LHb and MHb control the dopaminergic and serotonergic systems (VP -> LHbM, abstract)
LAC FAM.FD.LHB.LT LAC.FD.HT.LTN Lateral Hypothalamic Nucleus nucleus-nucleus Regulation of the rapid eye movement (REM) sleep by habenular projection (LHT -> LHbL)
LAC.FD.HT.VLPO Ventrolateral Preoptic Nucleus nucleus-nucleus Habenula Connections (LPO -> LHb, abstract)
FAM.FD.LHB.MED LAC.FD.HT.LTN Lateral Hypothalamic Nucleus nucleus-nucleus Both LHb and MHb control the dopaminergic and serotonergic systems (LHA -> LHbM)
LAC.FD.HT.VLPO Ventrolateral Preoptic Nucleus nucleus-nucleus Both LHb and MHb control the dopaminergic and serotonergic systems (LPO -> LHbM)
LMC FAM.FD.LHB.LT LMC.HT.LC Locus Coeruleus nucleus-nucleus-NE Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> LHB, abstract)
FAM.FD.LHB.MED LMC.HT.LC Locus Coeruleus nucleus-nucleus-NE Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> LHB, abstract)

External Outbound Region Connections:

Target Area Local Region Target Region Target Name Type Reference
Subcortical
FAM FAM.FD.LHB.MED FAM.HT.TG.NI Incertus Nucleus nucleus-nucleus Regulation of the rapid eye movement (REM) sleep by habenular projection (LHbM -> NI)
FEC FAM.FD.LHB.LT FEC.HT.TG.RMTG Rostromedial Tegmental Nucleus nucleus-nucleus Both LHb and MHb control the dopaminergic and serotonergic systems (LHbL -> RMTg)
FAM.FD.LHB.MED FEC.FT.SNC.LT Substantia Nigra Pars Compacta Lateral nucleus-nucleus Habenula Connections (LHb -> SNc, abstract)
FEC.HT.TG.RMTG Rostromedial Tegmental Nucleus nucleus-nucleus Regulation of the rapid eye movement (REM) sleep by habenular projection (LHbM -> RMTg)
LMC FAM.FD.LHB.MED LMC.HL.RP.MG Raphe Magnus Nucleus nucleus-nucleus Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> MRN, abstract)
LMC.HT.TG.LDT Laterodorsal Tegmental Nucleus nucleus-nucleus Regulation of the rapid eye movement (REM) sleep by habenular projection (LHbM -> DTG)
LMC.MM.RP.DRN Dorsal Raphe Nucleus nucleus-nucleus Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> DRN)
LMC.MM.RP.SUC Superior Central Raphe Nucleus nucleus-nucleus Habenula Connections (LHb -> MR, abstract)
LMC.MM.VTA Ventral Tegmental Area nucleus-nucleus Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> VTA)

Conscious Emotions Control

unavailable

Component ID Component Name Type Service Function Comments
FAM.FT.AM.BP Parvicellular Basal Amygdaloid Nucleus nucleus FAU enhance explicit memories in hippocampus about emotional situations
FAM.FT.AM.ITC Intercalated Amygdaloid Nuclei nucleus FAU inhibit excessive emotional behavior inhibitory
FAM.FT.SEP.SF Septofimbrial Nucleus nucleus FAU afferent to medial habenula, primary input to indirect encoding negative feedback
FAM.FT.SEP.TR Triangular Septal Nucleus nucleus FAU afferent to medial habenula, interpeduncular nucleus

Internal Region Connections:

  • no connections

External Inbound Region Connections:

Source Area Local Region Source Region Source Name Type Reference
Cortical
NDM FAM.FT.AM.BP NDM.NC.AL.DACG Dorsal Anterior Cingulate Area neocortex-nucleus Role for serotonin in moral behavior (ACG -> AMY, abstract)
NDM.NC.AL.FPC Lateral Frontopolar Cortex neocortex-nucleus Amygdala and its network (MPFC -> BLN, abstract)
NDM.NC.AL.VACG Ventral Anterior Cingulate Area neocortex-nucleus Role for serotonin in moral behavior (ACG -> AMY, abstract)
FAM.FT.AM.ITC NDM.NC.AL.DMPFC Dorsomedial Prefrontal Cortex neocortex-nucleus (unknown reference)
NDM.NC.AL.VMPFC Ventromedial Prefrontal Cortex neocortex-nucleus (unknown reference)
Subcortical
FAM FAM.FT.AM.BP FAM.FT.AM.LADL Dorsolateral Amygdaloid Nucleus nucleus-nucleus Amygdala and its network (LA -> BLN, abstract)
FAM.FT.AM.LAVL Ventrolateral Amygdaloid Nucleus nucleus-nucleus Amygdala and its network (LA -> BLN, abstract)
FAM.FT.AM.ITC FAM.FT.AM.BM Magnocellular Basal Amygdaloid Nucleus nucleus-nucleus (unknown reference)
FAM.FT.AM.LADL Dorsolateral Amygdaloid Nucleus nucleus-nucleus (unknown reference)
FAM.FT.SEP.SF FAM.HT.TG.NI Incertus Nucleus nucleus-nucleus-gaba (unknown reference)
FAM.FT.SEP.TR FAM.HT.TG.NI Incertus Nucleus nucleus-nucleus-gaba (unknown reference)
FMM FAM.FT.SEP.SF FMM.FT.HC.CA3D Distal CA3 of Hippocampus allocortex-nucleus Connectivity map of the habenula (Hippo -> Septum, abstract)
FAM.FT.SEP.TR FMM.FT.HF.SUBD Distal Subiculum allocortex-nucleus Principal Connections of Hippocampus (HC -> SEP, abstract)

External Outbound Region Connections:

Target Area Local Region Target Region Target Name Type Reference
Cortical
NDM FAM.FT.AM.BP NDM.FD.TH.MDM Medial Mediodorsal Nucleus of Thalamus nucleus-nucleus Amygdala and its network (BLN -> MD, abstract)
Subcortical
FAM FAM.FT.AM.BP FAM.FT.AM.BM Magnocellular Basal Amygdaloid Nucleus nucleus-nucleus (unknown reference)
FAM.FT.AM.CEM Medial Central Amygdaloid Nucleus nucleus-nucleus Amygdala and its network (BLN -> CEA, abstract)
FAM.FT.AM.ITC FAM.FT.AM.CEM Medial Central Amygdaloid Nucleus nucleus-nucleus-gaba (unknown reference)
FAM.FT.SEP.SF FAM.FD.MHB Medial Habenula nucleus-nucleus-gaba Connectivity map of the habenula (Septum -> M, abstract)
FAM.FT.SEP.TR FAM.FD.MHB Medial Habenula nucleus-nucleus-gaba Connectivity map of the habenula (Septum -> M, abstract)
FEC FAM.FT.AM.BP FEC.FT.ACC.CORE Nucleus Accumbens Core nucleus-nucleus Amygdala and its network (BLN -> NACC, abstract)
FMM FAM.FT.AM.BP FMM.FT.HC.CA1D Distal CA1 of Hippocampus nucleus-allocortex Detailed amygdalohippocampal projections (Bpc -> CA1D)
FMM.NC.PH.LEC Lateral Entorhinal Cortex nucleus-neocortex Principal Connections of Hippocampus (AM -> EC, abstract)
FMM.NC.PH.PAS Parasubiculum nucleus-neocortex Detailed amygdalohippocampal projections (Bpc -> PaS)
FMM.NC.PH.PRS Presubiculum nucleus-neocortex Detailed amygdalohippocampal projections (Bpc -> PrS)
LAC FAM.FT.AM.BP LAC.FD.HT.DM Dorsomedial Hypothalamic Nucleus nucleus-nucleus Role for serotonin in moral behavior (AMY -> HYP, abstract)
LAC.FD.HT.LTN Lateral Hypothalamic Nucleus nucleus-nucleus Amygdala and its network (BLN -> HTS)
LAC.FD.HT.PN Posterior Hypothalamic Nucleus nucleus-nucleus Role for serotonin in moral behavior (AMY -> HYP, abstract)
LMC FAM.FT.AM.BP LMC.FT.NBM Basal Nucleus of Meynert nucleus-nucleus (unknown reference)

Conditional Context Sensory Data and Memory Attention

unavailable

Component ID Component Name Type Service Function Comments
FAM.FD.TH.PT Paratenial Nucleus of Thalamus nucleus FAU Gateway for multimodal information to limbic system used in selecting appropriate
responses
Projects to BNST, AM, OMPFC, ET; Direct behavior
toward a particular outcome over a range of
outcomes
FAM.FT.AM.AB Accessory Basal Amygdaloid Nucleus nucleus FAU enhance assotiative memory formation proections to matrix of core of NACC
FAM.FT.AM.BM Magnocellular Basal Amygdaloid Nucleus nucleus FAU enhance emotional memories memories in medial prefrontal cortex
FAM.FT.AM.COA Anterior Cortical Amygdaloid Nucleus nucleus FAU olfactory processing - conditional contextual signaling
FAM.FT.AM.LADL Dorsolateral Amygdaloid Nucleus nucleus FAU conditional stimulus input - high-aggregated visual, auditory and somatic,
patterns of perception
LA2

Internal Region Connections:

Source Region Target Region Type Reference
FAM.FT.AM.COA FAM.FT.AM.AB nucleus-nucleus (unknown reference)
FAM.FT.AM.LADL FAM.FT.AM.AB nucleus-nucleus Summary of the main extra-amygdaloid and intra-amygdaloid connections in the rat (L -> AB, abstract)

External Inbound Region Connections:

Source Area Local Region Source Region Source Name Type Reference
Cortical
NCP FAM.FT.AM.BM NCP.NC.INS.PIC Posterior Insular Cortex neocortex-nucleus Afferent pain pathways (Insula -> AMY, abstract)
FAM.FT.AM.LADL NCP.NC.INS.PPC Peripaleocortical Claustral neocortex-nucleus Afferent pain pathways (Insula -> AMY, abstract)
NDM FAM.FT.AM.BM NDM.NC.AL.FPC Lateral Frontopolar Cortex neocortex-nucleus Bowels control brain: gut hormones and obesity (OFC -> AMY, abstract)
FAM.FT.AM.LADL NDM.NC.AL.VMPFC Ventromedial Prefrontal Cortex neocortex-nucleus (unknown reference)
NSA FAM.FT.AM.LADL NSA.FD.TH.MGB Medial Geniculate Body nucleus-nucleus Amygdalar disruption of prefrontal cortex (TH -> AM, abstract)
NSA.NC.IT.TE Inferotemporal Cortex neocortex-nucleus Amygdala and its network (ITC -> LA, abstract)
Subcortical
FAM FAM.FT.AM.AB FAM.FT.AM.LAVM Ventromedial Amygdaloid Nucleus nucleus-nucleus Summary of the main extra-amygdaloid and intra-amygdaloid connections in the rat (L -> AB, abstract)
FAM.FT.AM.BM FAM.FT.AM.BP Parvicellular Basal Amygdaloid Nucleus nucleus-nucleus (unknown reference)
FAM.FT.AM.LADL FAM.FT.IPAC.MED Medial Interstitial Anterior Commissural Nucleus nucleus-nucleus (unknown reference)
FEC FAM.FD.TH.PT FEC.FT.VP.VM Ventral Pallidum Ventromedial nucleus-nucleus-gaba Saccadic Vision (BG -> Thalamus, abstract)
FMM FAM.FT.AM.AB FMM.FT.HF.SUBD Distal Subiculum allocortex-nucleus Simplified model of hippocampal formation anatomy (SUB -> Amyg, abstract)
FMM.FT.HF.SUBP Proximal Subiculum allocortex-nucleus Simplified model of hippocampal formation anatomy (SUB -> Amyg, abstract)
FMM.NC.PH.LEC Lateral Entorhinal Cortex neocortex-nucleus Simplified model of hippocampal formation anatomy (EC -> Amyg, abstract)
LAC FAM.FD.TH.PT LAC.FD.HT.MPO Median Preoptic Nucleus nucleus-nucleus (unknown reference)
LMC FAM.FT.AM.BM LMC.FT.NBM Basal Nucleus of Meynert nucleus-nucleus-ACh (unknown reference)
LPC FAM.FT.AM.COA LPC.FT.MOB Main Olfactory Bulb nucleus-nucleus (unknown reference)

External Outbound Region Connections:

Target Area Local Region Target Region Target Name Type Reference
Cortical
NCP FAM.FD.TH.PT NCP.NC.MPL.PSCG Posterior Cingulate Cortex nucleus-neocortex Contributions of Diencephalon to Recognition Memory (MID -> PostCingulate, abstract)
NCP.NC.MPL.RSC Retrosplenial Cortex nucleus-neocortex (unknown reference)
FAM.FT.AM.BM NCP.NC.MPL.PSCG Posterior Cingulate Cortex nucleus-neocortex Oculomotor decision-making (AMYG -> CGp, abstract)
NDM FAM.FD.TH.PT NDM.NC.AL.ROFCR Most Rostral Orbitofrontal Cortex nucleus-neocortex Saccadic Vision (Thalamus -> FrontalCortex, abstract)
FAM.FT.AM.AB NDM.FD.TH.MDM Medial Mediodorsal Nucleus of Thalamus nucleus-nucleus Prefrontal Cortex (PFC) in emotional behavior (AM -> TH, abstract)
NDM.NC.AL.DACG Dorsal Anterior Cingulate Area nucleus-neocortex Amygdalar disruption of prefrontal cortex (AM -> ACG, abstract)
NDM.NC.AL.VACG Ventral Anterior Cingulate Area nucleus-neocortex Amygdalar disruption of prefrontal cortex (AM -> ACG, abstract)
NPE FAM.FD.TH.PT NPE.FD.TH.MPV Medial Pulvinar nucleus-nucleus Contributions of Diencephalon to Recognition Memory (MID -> mPULV, abstract)
NSA FAM.FT.AM.BM NSA.NC.TTG.A1 Primary Auditory Cortex nucleus-neocortex Visual-Auditory Interactions in Tectum (AM -> AC, abstract)
Subcortical
FAM FAM.FD.TH.PT FAM.FT.AM.LAVL Ventrolateral Amygdaloid Nucleus nucleus-nucleus Amygdalar disruption of prefrontal cortex (TH -> AM, abstract)
FAM.FT.BNST Bed Nucleus of Stria Terminalis nucleus-nucleus (unknown reference)
FAM.FT.AM.AB FAM.FT.AM.CEM Medial Central Amygdaloid Nucleus nucleus-nucleus Summary of the main extra-amygdaloid and intra-amygdaloid connections in the rat (AB -> CE, abstract)
FAM.FT.AM.MPD Medial Posterior Dorsal Amygdaloid Nucleus nucleus-nucleus Summary of the main extra-amygdaloid and intra-amygdaloid connections in the rat (AB -> M, abstract)
FAM.FT.AM.BM FAM.FT.AM.ITC Intercalated Amygdaloid Nuclei nucleus-nucleus (unknown reference)
FAM.FT.AM.LADL FAM.FT.AM.BP Parvicellular Basal Amygdaloid Nucleus nucleus-nucleus Amygdala and its network (LA -> BLN, abstract)
FAM.FT.AM.CEC Central Amygdaloid Nucleus, capsular subdivision nucleus-nucleus Amygdala and its network (LA -> CEA, abstract)
FAM.FT.AM.ITC Intercalated Amygdaloid Nuclei nucleus-nucleus (unknown reference)
FAM.FT.AM.LAVM Ventromedial Amygdaloid Nucleus nucleus-nucleus (unknown reference)
FEC FAM.FD.TH.PT FEC.FT.ACC.CORE Nucleus Accumbens Core nucleus-nucleus (unknown reference)
FAM.FT.AM.AB FEC.FT.CN.TL Caudate Nucleus Tail nucleus-nucleus (unknown reference)
FMM FAM.FD.TH.PT FMM.NC.PH.LEC Lateral Entorhinal Cortex nucleus-neocortex Contributions of Diencephalon to Recognition Memory (MID -> EC, abstract)
FAM.FT.AM.AB FMM.FT.HC.CA1P Proximal CA1 of Hippocampus nucleus-allocortex Detailed amygdalohippocampal projections (ABmg -> CA1P)
LMC FAM.FT.AM.AB LMC.FT.NBM Basal Nucleus of Meynert nucleus-nucleus (unknown reference)

Express Flight Emotions

unavailable

Component ID Component Name Type Service Function Comments
FAM.FT.AM.MEA Medial Anterior Amygdaloid Nucleus nucleus FAU olfactory processing
FAM.FT.AM.MPD Medial Posterior Dorsal Amygdaloid Nucleus nucleus FAU reproductive behavior MePD -> HT-MPN
FAM.FT.AM.MPV Medial Posterior Ventral Amygdaloid Nucleus nucleus FAU defensive behavior MePV -> LAC.FD.HT.VM (reproductive+defensive),
LAC.FD.HT.AH (defensive)
FAM.FT.BNST Bed Nucleus of Stria Terminalis nucleus FAU Mediate slow longer-lasting responses that accompany sustained threats Major output from AM to HT, part of extended
amygdala; medial part continues to medial AM,
central part continues to central AM
FAM.FT.IPAC.MED Medial Interstitial Anterior Commissural Nucleus nucleus FAU Sharp, acute pain sensation reciprocate its afferent connections, similar to
medial part of central amygdaloid nucleus;
projections to AM-Ce/BNST components, PB, and SOL
originate chiefly from medial division; strong ACh
projections from caudal IPACm to AM-BL-posterior
and amygdalopiriform transition area
FAM.FT.SEP.BAC Bed Nucleus of Anterior Commissure nucleus FAU projection to contralateral HC

Internal Region Connections:

Source Region Target Region Type Reference
FAM.FT.AM.MEA FAM.FT.AM.MPD nucleus-nucleus (unknown reference)
FAM.FT.AM.MPV nucleus-nucleus (unknown reference)
FAM.FT.BNST nucleus-nucleus (unknown reference)
FAM.FT.IPAC.MED nucleus-nucleus (unknown reference)
FAM.FT.BNST FAM.FT.IPAC.MED nucleus-nucleus (unknown reference)
FAM.FT.SEP.BAC nucleus-nucleus (unknown reference)

External Inbound Region Connections:

Source Area Local Region Source Region Source Name Type Reference
Cortical
NCP FAM.FT.BNST NCP.NC.AL.SGCG Subgenual Cingulate Cortex neocortex-nucleus (unknown reference)
NDM FAM.FT.BNST NDM.FD.TH.PV Paraventricular Nucleus of Thalamus nucleus-nucleus (unknown reference)
NSA FAM.FT.IPAC.MED NSA.NC.PH.PIR Piriform Cortex neocortex-nucleus (unknown reference)
Subcortical
FAM FAM.FT.AM.MEA FAM.FT.AM.COP Posterior Cortical Amygdaloid Nucleus nucleus-nucleus (unknown reference)
FAM.FT.AM.MPD FAM.FT.AM.AB Accessory Basal Amygdaloid Nucleus nucleus-nucleus Summary of the main extra-amygdaloid and intra-amygdaloid connections in the rat (AB -> M, abstract)
FAM.FT.AM.MPV FAM.FT.AM.LAVM Ventromedial Amygdaloid Nucleus nucleus-nucleus Summary of the main extra-amygdaloid and intra-amygdaloid connections in the rat (L -> M, abstract)
FAM.FT.BNST FAM.FD.TH.PT Paratenial Nucleus of Thalamus nucleus-nucleus (unknown reference)
FAM.FT.AM.CEL Central Amygdaloid Nucleus, lateral subdivision nucleus-nucleus (unknown reference)
LAC FAM.FT.BNST LAC.FD.HT.VM Ventromedial Hypothalamic Nucleus nucleus-nucleus (unknown reference)
LPC FAM.FT.AM.MEA LPC.FT.AOB Accessory Olfactory Bulb nucleus-nucleus (unknown reference)

External Outbound Region Connections:

Target Area Local Region Target Region Target Name Type Reference
Subcortical
FAM FAM.FT.AM.MEA FAM.FT.AM.CEM Medial Central Amygdaloid Nucleus nucleus-nucleus Body alarm system (MED -> CE, abstract)
FAM.FT.AM.MPV FAM.FT.SEP.LT Lateral Septal Nucleus nucleus-nucleus-gaba (unknown reference)
FAM.FT.IPAC.MED FAM.FT.AM.LADL Dorsolateral Amygdaloid Nucleus nucleus-nucleus (unknown reference)
FAM.FT.SEP.BAC FAM.FD.MHB Medial Habenula nucleus-nucleus Connectivity map of the habenula (Septum -> M, abstract)
FEC FAM.FT.BNST FEC.FT.SNC.MED Substantia Nigra Pars Compacta Medial nucleus-nucleus (unknown reference)
FMM FAM.FT.AM.MPV FMM.FD.TH.RE Reuniens Nucleus of Thalamus nucleus-nucleus-gaba Oculomotor decision-making (AMYG -> Thalamus, abstract)
FAM.FT.SEP.BAC FMM.FT.HF.SUBP Proximal Subiculum nucleus-allocortex Medial mammillary nucleus and theta rhythm (SEP -> HF, abstract)
LAC FAM.FT.AM.MEA LAC.FD.HT.VLPO Ventrolateral Preoptic Nucleus nucleus-nucleus Role for serotonin in moral behavior (AMY -> HYP, abstract)
FAM.FT.AM.MPD LAC.FD.HT.MPO Median Preoptic Nucleus nucleus-nucleus-gaba Role for serotonin in moral behavior (AMY -> HYP, abstract)
LAC.FD.HT.PV Paraventricular Nucleus nucleus-nucleus-gaba Amygdalar disruption of prefrontal cortex (AM -> HT.PV, abstract)
FAM.FT.AM.MPV LAC.FD.HT.PRM Premammillary Nucleus nucleus-nucleus-gaba Amygdalar disruption of prefrontal cortex (AM -> HT.L, abstract)
LAC.FD.HT.VM Ventromedial Hypothalamic Nucleus nucleus-nucleus-gaba Role for serotonin in moral behavior (AMY -> HYP, abstract)
LMC FAM.FT.BNST LMC.FT.NBM Basal Nucleus of Meynert nucleus-nucleus (unknown reference)
LMC.HT.LC Locus Coeruleus nucleus-nucleus (unknown reference)
LMC.MM.VTA Ventral Tegmental Area nucleus-nucleus (unknown reference)
LPC FAM.FT.IPAC.MED LPC.HL.SOL Solitary Nucleus nucleus-nucleus (unknown reference)
LPC.HT.PRF.PB Parabrachial Nucleus nucleus-nucleus (unknown reference)

Express Fight Emotions

unavailable

Component ID Component Name Type Service Function Comments
FAM.FT.AM.CEM Medial Central Amygdaloid Nucleus nucleus FAU mediate behavioral responses, output projections
FAM.FT.SEP.SH Septohippocampal Nucleus nucleus FAU participate in solving conflict between two or more competing goals, defensive
circuit

Internal Region Connections:

  • no connections

External Inbound Region Connections:

Source Area Local Region Source Region Source Name Type Reference
Cortical
NDM FAM.FT.SEP.SH NDM.NC.AL.FPC Lateral Frontopolar Cortex neocortex-nucleus (unknown reference)
Subcortical
FAM FAM.FT.AM.CEM FAM.FT.AM.AB Accessory Basal Amygdaloid Nucleus nucleus-nucleus Summary of the main extra-amygdaloid and intra-amygdaloid connections in the rat (AB -> CE, abstract)
FAM.FT.AM.BP Parvicellular Basal Amygdaloid Nucleus nucleus-nucleus Amygdala and its network (BLN -> CEA, abstract)
FAM.FT.AM.CEC Central Amygdaloid Nucleus, capsular subdivision nucleus-nucleus (unknown reference)
FAM.FT.AM.CEL Central Amygdaloid Nucleus, lateral subdivision nucleus-nucleus (unknown reference)
FAM.FT.AM.ITC Intercalated Amygdaloid Nuclei nucleus-nucleus-gaba (unknown reference)
FAM.FT.AM.MEA Medial Anterior Amygdaloid Nucleus nucleus-nucleus Body alarm system (MED -> CE, abstract)
FEC FAM.FT.AM.CEM FEC.FT.SNC.MED Substantia Nigra Pars Compacta Medial nucleus-nucleus-DA (unknown reference)

External Outbound Region Connections:

Target Area Local Region Target Region Target Name Type Reference
Subcortical
FAM FAM.FT.AM.CEM FAM.FT.SEP.LT Lateral Septal Nucleus nucleus-nucleus (unknown reference)
LAC FAM.FT.AM.CEM LAC.FD.HT.LTN Lateral Hypothalamic Nucleus nucleus-nucleus Amygdalar disruption of prefrontal cortex (AM -> HT.L, abstract)
LAC.HL.VGN Vagus Nucleus nucleus-nucleus Amygdala and its network (CEA -> VGDM, abstract)
FAM.FT.SEP.SH LAC.FD.HT.LTN Lateral Hypothalamic Nucleus nucleus-nucleus Cingulate Gyrus (SEP -> HT, abstract)
LMC FAM.FT.AM.CEM LMC.FT.NBM Basal Nucleus of Meynert nucleus-nucleus (unknown reference)
LMC.HT.LC Locus Coeruleus nucleus-nucleus Amygdalar disruption of prefrontal cortex (AM -> LC, abstract)
LMC.MM.PAG Periaqueductal Gray Matter nucleus-nucleus Amygdalar disruption of prefrontal cortex (AM -> PAG, abstract)

Solving Fight-Flight Dilemma

unavailable

Component ID Component Name Type Service Function Comments
FAM.FT.SEP.LT Lateral Septal Nucleus nucleus FAU promote active stress coping behavior

Internal Region Connections:

  • no connections

External Inbound Region Connections:

Source Area Local Region Source Region Source Name Type Reference
Subcortical
FAM FAM.FT.SEP.LT FAM.FT.AM.CEM Medial Central Amygdaloid Nucleus nucleus-nucleus (unknown reference)
FAM.FT.AM.MPV Medial Posterior Ventral Amygdaloid Nucleus nucleus-nucleus-gaba (unknown reference)
FMM FAM.FT.SEP.LT FMM.FT.HC.CA1D Distal CA1 of Hippocampus allocortex-nucleus Connectivity map of the habenula (Hippo -> Septum, abstract)
LAC FAM.FT.SEP.LT LAC.FD.HT.PN Posterior Hypothalamic Nucleus nucleus-nucleus (unknown reference)
LAC.FD.HT.TBM Tuberomammillary Nucleus nucleus-nucleus (unknown reference)
LMC FAM.FT.SEP.LT LMC.MM.RP.SUC Superior Central Raphe Nucleus nucleus-nucleus-5HT (unknown reference)

External Outbound Region Connections:

Target Area Local Region Target Region Target Name Type Reference
Cortical
NDM FAM.FT.SEP.LT NDM.FD.TH.PV Paraventricular Nucleus of Thalamus nucleus-nucleus-gaba (unknown reference)
Subcortical
FAM FAM.FT.SEP.LT FAM.FD.LHB.MED Lateral Habenula Medial Part nucleus-nucleus-gaba Both LHb and MHb control the dopaminergic and serotonergic systems (LS -> LHbM)
LAC FAM.FT.SEP.LT LAC.FD.HT.VLPO Ventrolateral Preoptic Nucleus nucleus-nucleus-gaba Cingulate Gyrus (SEP -> HT, abstract)

Memory Formation Affective Focus

unavailable

Component ID Component Name Type Service Function Comments
FAM.FT.SEP.DBB Diagonal Band of Broca nucleus FAU involved in generation of theta waves in hippocampus ACh and GABA; ventral group - from stria terminalis
to/from MFB
FAM.FT.SEP.MED Medial Septal Nucleus nucleus FAU affect HC for spatial learning, generation of theta waves output nucleus; projections from AM and HC overlap;
control theta rythm and exprolatory behavior;
from/to MFB to fornix fimbria

Internal Region Connections:

  • no connections

External Inbound Region Connections:

Source Area Local Region Source Region Source Name Type Reference
Subcortical
LAC FAM.FT.SEP.DBB LAC.FD.HT.SUM Supramammillary Nucleus nucleus-nucleus Medial mammillary nucleus and theta rhythm (SupraMM -> SEP, abstract)
FAM.FT.SEP.MED LAC.FD.HT.SUM Supramammillary Nucleus nucleus-nucleus Medial mammillary nucleus and theta rhythm (SupraMM -> SEP, abstract)
LMC FAM.FT.SEP.DBB LMC.HT.LC Locus Coeruleus nucleus-nucleus-NE (unknown reference)

External Outbound Region Connections:

Target Area Local Region Target Region Target Name Type Reference
Cortical
NCP FAM.FT.SEP.MED NCP.NC.MPL.RSC Retrosplenial Cortex nucleus-neocortex-ACh Medial mammillary nucleus and theta rhythm (SEP -> RSP, abstract)
NDM FAM.FT.SEP.DBB NDM.NC.AL.VMPFC Ventromedial Prefrontal Cortex nucleus-neocortex-gaba (unknown reference)
FAM.FT.SEP.MED NDM.FD.TH.MDM Medial Mediodorsal Nucleus of Thalamus nucleus-nucleus-ACh Thalamocortical relationships (s1MD -> MD, abstract)
Subcortical
FAM FAM.FT.SEP.DBB FAM.FD.LHB.MED Lateral Habenula Medial Part nucleus-nucleus-gaba Both LHb and MHb control the dopaminergic and serotonergic systems (DBB -> LHbM)
FAM.FD.MHB Medial Habenula nucleus-nucleus-gaba Habenula Connections (DBB -> MHb)
FAM.FT.SEP.MED FAM.FD.MHB Medial Habenula nucleus-nucleus-ACh Both LHb and MHb control the dopaminergic and serotonergic systems (MS -> MHb)
FEC FAM.FT.SEP.MED FEC.FD.TH.PF Parafascicular Nucleus of Thalamus nucleus-nucleus-ACh (unknown reference)
FMM FAM.FT.SEP.DBB FMM.FD.MB.MMB Medial Mammillary Nucleus nucleus-nucleus-gaba Cingulate Gyrus (SEP -> HT, abstract)
FMM.FT.HC.CA2 Dorsolateral Cornu Ammonis of Hippocampus nucleus-allocortex-gaba Medial mammillary nucleus and theta rhythm (SEP -> HF, abstract)
FAM.FT.SEP.MED FMM.FD.MB.LMB Lateral Mammillary Nucleus nucleus-nucleus-ACh Cingulate Gyrus (SEP -> HT, abstract)
FMM.FD.MB.MMB Medial Mammillary Nucleus nucleus-nucleus-gaba Cingulate Gyrus (SEP -> HT, abstract)

Reward Emotions Control

unavailable

Component ID Component Name Type Service Function Comments
FAM.FD.MHB Medial Habenula nucleus FAU Encoding negative feedback, indirect affects VTA, dorsal raphe but via interpeduncular
nucleus
FAM.FT.EPF Endopiriform Nucleus nucleus FAU Putative relay of limbic-associated cortical-like areas subserving affective
information
FAM.HT.TG.NI Incertus Nucleus nucleus FAU Behavioural activation and the response to stress Modulating influences on prefrontal and hippocampal
cortical activity, midline behavior control;
modulatory nucleus; relay from reticularis pontis
oralis nucleus to septo-hippocampal system

Internal Region Connections:

Source Region Target Region Type Reference
FAM.HT.TG.NI FAM.FT.EPF nucleus-nucleus-gaba (unknown reference)

External Inbound Region Connections:

Source Area Local Region Source Region Source Name Type Reference
Cortical
NSA FAM.FT.EPF NSA.NC.PH.PIR Piriform Cortex neocortex-nucleus Gustatory sensory system of rat and macaque (PiR -> EnP)
Subcortical
FAM FAM.FD.MHB FAM.FT.SEP.BAC Bed Nucleus of Anterior Commissure nucleus-nucleus Connectivity map of the habenula (Septum -> M, abstract)
FAM.FT.SEP.DBB Diagonal Band of Broca nucleus-nucleus-gaba Habenula Connections (DBB -> MHb)
FAM.FT.SEP.MED Medial Septal Nucleus nucleus-nucleus-ACh Both LHb and MHb control the dopaminergic and serotonergic systems (MS -> MHb)
FAM.FT.SEP.SF Septofimbrial Nucleus nucleus-nucleus-gaba Connectivity map of the habenula (Septum -> M, abstract)
FAM.FT.SEP.TR Triangular Septal Nucleus nucleus-nucleus-gaba Connectivity map of the habenula (Septum -> M, abstract)
FAM.HT.TG.NI FAM.FD.LHB.MED Lateral Habenula Medial Part nucleus-nucleus Regulation of the rapid eye movement (REM) sleep by habenular projection (LHbM -> NI)
FEC FAM.FD.MHB FEC.FT.ACC.SH Nucleus Accumbens Shell nucleus-nucleus-gaba Connectivity map of the habenula (NAc -> M, abstract)
FAM.FT.EPF FEC.FT.PU.VT Ventral Putamen nucleus-nucleus-gaba Connectivity map of the habenula (CPu -> EP, abstract)
LMC FAM.FD.MHB LMC.HT.LC Locus Coeruleus nucleus-nucleus-NE Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> MHB)
LRC FAM.HT.TG.NI LRC.HT.PRF.RPO Oral Pontine Reticular Nucleus nucleus-nucleus (unknown reference)

External Outbound Region Connections:

Target Area Local Region Target Region Target Name Type Reference
Cortical
NCP FAM.FT.EPF NCP.NC.INS.AIC Anterior Insular Cortex nucleus-neocortex Gustatory sensory system of rat and macaque (EnP -> Iav, abstract)
Subcortical
FAM FAM.FD.MHB FAM.FD.LHB.MED Lateral Habenula Medial Part nucleus-nucleus Connectivity map of the habenula (M -> L, abstract)
FAM.FT.EPF FAM.FD.LHB.LT Lateral Habenula Lateral Part nucleus-nucleus Regulation of the rapid eye movement (REM) sleep by habenular projection (EPN -> LHbL)
FAM.HT.TG.NI FAM.FT.SEP.SF Septofimbrial Nucleus nucleus-nucleus-gaba (unknown reference)
FAM.FT.SEP.TR Triangular Septal Nucleus nucleus-nucleus-gaba (unknown reference)
FEC FAM.FD.MHB FEC.HT.TG.IPD Interpeduncular Nucleus nucleus-nucleus Connectivity map of the habenula (M -> IPN)
FMM FAM.HT.TG.NI FMM.NC.PH.PER Perirhinal Cortex nucleus-neocortex-gaba (unknown reference)

Fast Unconditional Sensory Data and Association Memory

unavailable

Component ID Component Name Type Service Function Comments
FAM.FT.AM.CEC Central Amygdaloid Nucleus, capsular subdivision nucleus FAU mediate behavioral responses, link to striatal effect gustatory, somatosensory, visual, auditory, frontal
cortex, perirhinal cortex, ET, SUB -> X ->
HT-dl/cl, CeM
FAM.FT.AM.CEL Central Amygdaloid Nucleus, lateral subdivision nucleus FAU mediate behavioral responses, link to gustatory and visceral aspects of
reinforcement
contributions of food prediction and food
presentation
FAM.FT.AM.COP Posterior Cortical Amygdaloid Nucleus nucleus FAU olfactory processing - unconditional signaling
FAM.FT.AM.LAVL Ventrolateral Amygdaloid Nucleus nucleus FAU unconditional stimulus input - visual, auditory and somatic, convergence from
thalamus
LA1; LGN, MGBm, PIL
FAM.FT.AM.LAVM Ventromedial Amygdaloid Nucleus nucleus FAU conditional and unconditional convergence to affect polymodal memory formation LA3; projects to ET

Internal Region Connections:

  • no connections

External Inbound Region Connections:

Source Area Local Region Source Region Source Name Type Reference
Cortical
NCP FAM.FT.AM.CEL NCP.NC.PO.PCC Precentral Cortex neocortex-nucleus (unknown reference)
NSA FAM.FT.AM.LAVL NSA.FD.TH.SG Suprageniculate Nucleus of Thalamus nucleus-nucleus Amygdalar disruption of prefrontal cortex (TH -> AM, abstract)
FAM.FT.AM.LAVM NSA.NC.STG.A3 Wernicke's area A3 neocortex-nucleus Amygdala and its network (STC -> LA, abstract)
Subcortical
FAM FAM.FT.AM.CEC FAM.FT.AM.LADL Dorsolateral Amygdaloid Nucleus nucleus-nucleus Amygdala and its network (LA -> CEA, abstract)
FAM.FT.AM.LAVL FAM.FD.TH.PT Paratenial Nucleus of Thalamus nucleus-nucleus Amygdalar disruption of prefrontal cortex (TH -> AM, abstract)
FAM.FT.AM.LAVM FAM.FT.AM.LADL Dorsolateral Amygdaloid Nucleus nucleus-nucleus (unknown reference)
FMM FAM.FT.AM.LAVM FMM.FT.HC.CA1D Distal CA1 of Hippocampus allocortex-nucleus Fear regulation (Hippocampus -> LA, abstract)
FMM.NC.PH.LEC Lateral Entorhinal Cortex neocortex-nucleus Simplified model of hippocampal formation anatomy (EC -> Amyg, abstract)
LMC FAM.FT.AM.CEC LMC.MM.VTA Ventral Tegmental Area nucleus-nucleus-DA Reward circuit of human brain (VTA -> AM, abstract)
LPC FAM.FT.AM.CEL LPC.HT.PRF.PB Parabrachial Nucleus nucleus-nucleus Amygdalar disruption of prefrontal cortex (PB -> AM, abstract)
FAM.FT.AM.COP LPC.FT.AOB Accessory Olfactory Bulb nucleus-nucleus (unknown reference)

External Outbound Region Connections:

Target Area Local Region Target Region Target Name Type Reference
Cortical
NDM FAM.FT.AM.LAVM NDM.FD.TH.PV Paraventricular Nucleus of Thalamus nucleus-nucleus Oculomotor decision-making (AMYG -> Thalamus, abstract)
Subcortical
FAM FAM.FT.AM.CEC FAM.FT.AM.CEM Medial Central Amygdaloid Nucleus nucleus-nucleus (unknown reference)
FAM.FT.AM.CEL FAM.FT.AM.CEM Medial Central Amygdaloid Nucleus nucleus-nucleus (unknown reference)
FAM.FT.BNST Bed Nucleus of Stria Terminalis nucleus-nucleus (unknown reference)
FAM.FT.AM.COP FAM.FT.AM.MEA Medial Anterior Amygdaloid Nucleus nucleus-nucleus (unknown reference)
FAM.FT.AM.LAVL FAM.FT.AM.BP Parvicellular Basal Amygdaloid Nucleus nucleus-nucleus Amygdala and its network (LA -> BLN, abstract)
FAM.FT.AM.LAVM FAM.FT.AM.AB Accessory Basal Amygdaloid Nucleus nucleus-nucleus Summary of the main extra-amygdaloid and intra-amygdaloid connections in the rat (L -> AB, abstract)
FAM.FT.AM.MPV Medial Posterior Ventral Amygdaloid Nucleus nucleus-nucleus Summary of the main extra-amygdaloid and intra-amygdaloid connections in the rat (L -> M, abstract)
FMM FAM.FT.AM.LAVL FMM.NC.PH.PAS Parasubiculum nucleus-neocortex Detailed amygdalohippocampal projections (L -> PaS, abstract)
LAC FAM.FT.AM.COP LAC.FD.HT.SO Supraoptic Nucleus nucleus-nucleus Role for serotonin in moral behavior (AMY -> HYP, abstract)
LPC FAM.FT.AM.CEL LPC.HL.SOL Solitary Nucleus nucleus-nucleus (unknown reference)
FAM.FT.AM.LAVM LPC.MM.CIC Central Nucleus of Inferior Colliculus nucleus-nucleus Visual-Auditory Interactions in Tectum (AM -> IC, abstract)

Thirdparty Circuits

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References

(generated)