BrainRegionFEC FT SNC MED

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Substantia Nigra Pars Compacta Medial

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This page covers biological details of component Substantia Nigra Pars Compacta Medial. Region is part of aHuman target integrated biological model.

  • Top-down path to region: Forebrain Telencephalon -> Basal Ganglia (FEC.FT.BG) -> Substantia Nigra (FEC.FT.SN) -> Substantia Nigra Pars Compacta (FEC.FT.SNC) -> Substantia Nigra Pars Compacta Medial (FEC.FT.SNC.MED) (see Mind Maps)
  • Type: nucleus
  • Brain area: Forebrain - Execution Control Area
  • Role: basal.ganglia.nigracompacta
  • Function: motivational loop
  • Notes to function: VP, ventral circuits

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Components

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  • no child items defined

Connectivity

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FEC.FT.SNC.MED.dot.png

Inbound Region Connections:

Source Area Source Region Source Name Type Reference
FAM FAM.FT.BNST Bed Nucleus of Stria Terminalis excitatory-glu (unknown reference)
FEC FEC.FT.ACC.CORE Nucleus Accumbens Core inhibitory-gaba (unknown reference)
FEC.FT.GPI.RM Globus Pallidus Internal Rostromedial inhibitory-gaba Prefrontal Cortex (PFC) in motor behavior (GP -> SN, abstract)
FEC.FT.SNR.MED Substantia Nigra Pars Reticulata Medial inhibitory-gaba (unknown reference)
FEC.HT.TG.RMTG Rostromedial Tegmental Nucleus inhibitory-gaba Both LHb and MHb control the dopaminergic and serotonergic systems (RMTg -> SNc, abstract)
LMC LMC.HT.LC Locus Coeruleus modulatory-ne (unknown reference)

Outbound Region Connections:

Target Area Target Region Target Name Type Reference
FAM FAM.FT.AM.CEM Medial Central Amygdaloid Nucleus modulatory-da (unknown reference)
FEC FEC.FT.ACC.SH Nucleus Accumbens Shell modulatory-da Connectivity map of the habenula (SNc -> CPu, abstract)
LAC LAC.FD.HT.SUM Supramammillary Nucleus modulatory-da (unknown reference)
LRC LRC.HT.PRF.PVR Parvocellular Reticular Nucleus modulatory-da (unknown reference)

Thirdparty Circuits

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map: GPe=Globus Pallidus External,FEC.FT.GPE (Globus Pallidus External Lateral (FEC.FT.GPE.LT), Globus Pallidus External Medial (FEC.FT.GPE.MED), Globus Pallidus External Dorsal (FEC.FT.GPE.DS), Globus Pallidus External Rostromedial (FEC.FT.GPE.RM), Globus Pallidus External Dorsolateral (FEC.FT.GPE.DL)), GPi=Globus Pallidus Internal,FEC.FT.GPI (Globus Pallidus Internal Lateral (FEC.FT.GPI.LT), Globus Pallidus Internal Medial (FEC.FT.GPI.MED), Globus Pallidus Internal Dorsal (FEC.FT.GPI.DS), Globus Pallidus Internal Rostromedial (FEC.FT.GPI.RM), Globus Pallidus Internal Dorsolateral (FEC.FT.GPI.DL)), PPN=Pedunculopontine Tegmental Nuclei,LMC.HT.TG.PPN, SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (Substantia Nigra Pars Compacta Lateral (FEC.FT.SNC.LT), Substantia Nigra Pars Compacta Medial (FEC.FT.SNC.MED)), SNr=Substantia Nigra Pars Reticulata,FEC.FT.SNR (Substantia Nigra Pars Reticulata Dorsolateral (FEC.FT.SNR.DL), Substantia Nigra Pars Reticulata Rostromedial (FEC.FT.SNR.RM), Substantia Nigra Pars Reticulata Ventrolateral (FEC.FT.SNR.VL), Substantia Nigra Pars Reticulata Medial (FEC.FT.SNR.MED)), STN=Subthalamic Nucleus,FEC.FD.STN (Subthalamic Nucleus Caudal (FEC.FD.STN.CD), Subthalamic Nucleus Internal Caudal (FEC.FD.STN.ICD), Subthalamic Nucleus Dorsolateral (FEC.FD.STN.DL), Subthalamic Nucleus Lateral (FEC.FD.STN.LT), Subthalamic Nucleus Medial (FEC.FD.STN.MED)) unavailable

map: CPu=Striatum,FEC.FT.ST (Nucleus Accumbens Core (FEC.FT.ACC.CORE), Nucleus Accumbens Shell (FEC.FT.ACC.SH), Ventral Putamen (FEC.FT.PU.VT), Caudate Nucleus Head (FEC.FT.CN.HD), Caudate Nucleus Body (FEC.FT.CN.BD), Caudate Nucleus Tail (FEC.FT.CN.TL), Dorsal Putamen Lateral (FEC.FT.PU.LT), Dorsal Putamen Medial (FEC.FT.PU.MED)), EP=Endopiriform Nucleus,FAM.FT.EPF, Hippo=Hippocampus,FMM.FT.HC (Dentate Gyrus (FMM.FT.HC.DG), Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P), Middle CA1 of Hippocampus (FMM.FT.HC.CA1M), Distal CA1 of Hippocampus (FMM.FT.HC.CA1D), Dorsolateral Cornu Ammonis of Hippocampus (FMM.FT.HC.CA2), Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P), Middle CA3 of Hippocampus (FMM.FT.HC.CA3M), Distal CA3 of Hippocampus (FMM.FT.HC.CA3D)), IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD, L=Lateral Habenula,FAM.FD.LHB (Lateral Habenula Medial Part (FAM.FD.LHB.MED), Lateral Habenula Lateral Part (FAM.FD.LHB.LT)), LH=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN, M=Medial Habenula,FAM.FD.MHB, NAc=Accumbens Nucleus,FEC.FT.ACC (Nucleus Accumbens Core (FEC.FT.ACC.CORE), Nucleus Accumbens Shell (FEC.FT.ACC.SH)), PAG=Periaqueductal Gray Matter,LMC.MM.PAG, Raphe=Raphe Nuclei of Medulla,LMC.HL.RP (Raphe Pallidus Nucleus (LMC.HL.RP.PL), Raphe Obscurus Nucleus (LMC.HL.RP.OB), Raphe Magnus Nucleus (LMC.HL.RP.MG)), SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (Substantia Nigra Pars Compacta Lateral (FEC.FT.SNC.LT), Substantia Nigra Pars Compacta Medial (FEC.FT.SNC.MED)), Septum=Septal Nuclei,FAM.FT.SEP, VTA=Ventral Tegmental Area,LMC.MM.VTA unavailable


References

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