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Substantia Nigra Pars Compacta Medial

@@Home -> BiologicalLifeResearch -> BrainAreaFEC -> BrainRegionFEC_FT_SNC_MED

This page covers biological details of component Substantia Nigra Pars Compacta Medial. Region is part of aHuman target integrated biological model.

  • Top-down path to region: Forebrain Telencephalon -> Basal Ganglia (FEC.FT.BG) -> Substantia Nigra (FEC.FT.SN) -> Substantia Nigra Pars Compacta (FEC.FT.SNC) -> Substantia Nigra Pars Compacta Medial (FEC.FT.SNC.MED) (see Mind Maps)
  • Type: nucleus
  • Quality: L0
  • Brain area: Forebrain - Execution Control Area (FEC)
  • Area circuit: Motor Motivational Salience (FECLM)
  • Role: basal.ganglia.nigracompacta
  • Function: motivational loop
  • Notes to function:
    • VP, ventral circuits




  • no child items defined



Inbound Region Connections:

Source Area Source Region Source Name Type Role Reference
FAM FAM.FT.BNST Bed Nucleus of Stria Terminalis excitatory-glu uncertain (unknown reference)
FEC FEC.FT.ACC.CORE Nucleus Accumbens Core inhibitory-gaba uncertain (unknown reference)
FEC.FT.GPI.RM Globus Pallidus Internal Rostromedial inhibitory-gaba uncertain Prefrontal Cortex (PFC) in motor behavior (GP -> SN, abstract)
FEC.FT.SNR.MED Substantia Nigra Pars Reticulata Medial inhibitory-gaba uncertain (unknown reference)
FEC.HT.TG.RMTG Rostromedial Tegmental Nucleus inhibitory-gaba uncertain Both LHb and MHb control the dopaminergic and serotonergic systems (RMTg -> SNc, abstract)
LMC LMC.HT.LC Locus Coeruleus modulatory-ne uncertain (unknown reference)

Outbound Region Connections:

Target Area Target Region Target Name Type Role Reference
FAM FAM.FT.AM.CEM Medial Central Amygdaloid Nucleus modulatory-da uncertain (unknown reference)
FEC FEC.FT.ACC.SH Nucleus Accumbens Shell modulatory-da uncertain Connectivity map of the habenula (SNc -> CPu, abstract)
LAC LAC.FD.HT.SUM Supramammillary Nucleus modulatory-da uncertain (unknown reference)
LRC LRC.HT.PRF.PVR Parvocellular Reticular Nucleus modulatory-da uncertain (unknown reference)

Thirdparty Circuits


GPe=Globus Pallidus External,FEC.FT.GPE (see Basal Ganglia)
GPi=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia)
PPN=Pedunculopontine Tegmental Nuclei,LMC.HT.TG.PPN
SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia)
SNr=Substantia Nigra Pars Reticulata,FEC.FT.SNR (see Basal Ganglia)
STN=Subthalamic Nucleus,FEC.FD.STN (see Subthalamus Area)

CPu=Striatum,FEC.FT.ST (see Basal Ganglia)
EP=Endopiriform Nucleus,FAM.FT.EPF
Hippo=Hippocampus,FMM.FT.HC (see Hippocampal Formation)
IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD
L=Lateral Habenula,FAM.FD.LHB (see Habenula)
LH=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN
M=Medial Habenula,FAM.FD.MHB
NAc=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia)
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
Raphe=Raphe Nuclei of Medulla,LMC.HL.RP (see Medullary Reticular Formation)
SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia)
Septum=Septal Nuclei,FAM.FT.SEP
VTA=Ventral Tegmental Area,LMC.MM.VTA