BrainRegionLAC FD HT VLPO

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Ventrolateral Preoptic Nucleus

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This page covers biological details of component Ventrolateral Preoptic Nucleus. Region is part of aHuman target integrated biological model.

  • Top-down path to region: Forebrain Diencephalon -> Hypothalamus (FD.HT) -> Anterior Hypothalamus Area (LAC.FD.HT.AHT) -> Chiasmatic Area (LAC.FD.HT.CHS) -> Preoptic Nucleus (LAC.FD.HT.PO) -> Ventrolateral Preoptic Nucleus (LAC.FD.HT.VLPO) (see Mind Maps)
  • Type: nucleus
  • Brain area: Lower Brain - Autonomous Control Area
  • Role: processor.autonomic
  • Function: mediates non-REM sleep onset
  • Notes to function: lesions in VLPO result in insomnia

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Components

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  • no child items defined

Connectivity

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LAC.FD.HT.VLPO.dot.png

Inbound Region Connections:

Source Area Source Region Source Name Type Reference
FAM FAM.FT.AM.MEA Medial Anterior Amygdaloid Nucleus excitatory-glu Role for serotonin in moral behavior (AMY -> HYP, abstract)
FAM.FT.SEP.LT Lateral Septal Nucleus inhibitory-gaba Cingulate Gyrus (SEP -> HT, abstract)
FEC FEC.HT.TG.RMTG Rostromedial Tegmental Nucleus inhibitory-gaba (unknown reference)
LAC LAC.FD.HT.DM Dorsomedial Hypothalamic Nucleus excitatory-glu Eating and sleeping to survive (DMH -> VLPO)
LAC.FD.HT.SCN Suprachiasmatic Nucleus excitatory-glu (unknown reference)
LAC.FD.HT.TBM Tuberomammillary Nucleus excitatory-glu Simplified NREM sleep-promoting pathway (TMN -> VLPO)
LAC.FD.HT.VM Ventromedial Hypothalamic Nucleus excitatory-glu (unknown reference)
LMC LMC.HT.LC Locus Coeruleus modulatory-ne Simplified NREM sleep-promoting pathway (LC -> VLPO)
NSA NSA.NC.PH.PRP Prepyriform Cortex excitatory-glu (unknown reference)

Outbound Region Connections:

Target Area Target Region Target Name Type Reference
FAM FAM.FD.LHB.LT Lateral Habenula Lateral Part excitatory-glu Habenula Connections (LPO -> LHb, abstract)
FAM.FD.LHB.MED Lateral Habenula Medial Part excitatory-glu Both LHb and MHb control the dopaminergic and serotonergic systems (LPO -> LHbM)
LAC LAC.FD.HT.SUM Supramammillary Nucleus excitatory-glu (unknown reference)
LMC LMC.HT.TG.LDT Laterodorsal Tegmental Nucleus excitatory-glu Simplified NREM sleep-promoting pathway (VLPO -> LDTg)

Thirdparty Circuits

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References

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