Difference between revisions of "BrainRegionLMC MM PAG"

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* '''Top-down path to region''': Midbrain Mesencephalon -> [[BrainRegionLMC_MM_PAG|Periaqueductal Gray Matter]] (LMC.MM.PAG) (see [[OverallMindMaps|Mind Maps]])
 
* '''Top-down path to region''': Midbrain Mesencephalon -> [[BrainRegionLMC_MM_PAG|Periaqueductal Gray Matter]] (LMC.MM.PAG) (see [[OverallMindMaps|Mind Maps]])
 
* '''Type''': nucleus
 
* '''Type''': nucleus
* '''Brain area''': [[BrainAreaLMC|Lower Brain - Modulatory Contol Area]]
+
* '''Quality''': L0
 +
* '''Brain area''': [[BrainAreaLMC|Lower Brain - Modulatory Contol Area]] (LMC)
 +
* '''Area circuit''': Enkephalin -  Regulating Nociception in Body (ENK)
 
* '''Role''': processor.autonomic
 
* '''Role''': processor.autonomic
 
* '''Function''': Descending modulation of pain and in defensive behaviour
 
* '''Function''': Descending modulation of pain and in defensive behaviour
* '''Notes to function''': if there is a lesion in the PAG, then consciousness is lost; electrical stimulation of the PAG results in immediate and profound analgesia; modulatory nucleus
+
* '''Notes to function''':  
 +
** if there is a lesion in the PAG, then consciousness is lost
 +
**  electrical stimulation of the PAG results in immediate and profound analgesia
 +
**  modulatory nucleus
 
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= Components =
 
= Components =
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{| class=wikitable width=80%
 
{| class=wikitable width=80%
| '''Source Area''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Reference'''
+
| '''Source Area''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Role''' || '''Reference'''
 
|-
 
|-
| [[BrainAreaFAM|FAM]] || [[BrainRegionFAM_FT_AM_CEM|FAM.FT.AM.CEM]] || Medial Central Amygdaloid Nucleus || excitatory-glu || [http://neuropolitics.org/defaultmay10.asp Amygdalar disruption of prefrontal cortex (AM -> PAG, abstract)]
+
| [[BrainAreaFAM|FAM]] || [[BrainRegionFAM_FT_AM_CEM|FAM.FT.AM.CEM]] || Medial Central Amygdaloid Nucleus || excitatory-glu || uncertain ||[http://neuropolitics.org/defaultmay10.asp Amygdalar disruption of prefrontal cortex (AM -> PAG, abstract)]
 
|-
 
|-
| [[BrainAreaFEC|FEC]] || [[BrainRegionFEC_HT_TG_IPD|FEC.HT.TG.IPD]] || Interpeduncular Nucleus || modulatory-ach || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (IPN -> PAG)]
+
| [[BrainAreaFEC|FEC]] || [[BrainRegionFEC_HT_TG_IPD|FEC.HT.TG.IPD]] || Interpeduncular Nucleus || modulatory-ach || uncertain ||[http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (IPN -> PAG)]
 
|-
 
|-
| [[BrainAreaNCP|NCP]] || [[BrainRegionNCP_NC_AL_SGCG|NCP.NC.AL.SGCG]] || Subgenual Cingulate Cortex || excitatory-glu || (unknown reference)
+
| [[BrainAreaNCP|NCP]] || [[BrainRegionNCP_NC_AL_SGCG|NCP.NC.AL.SGCG]] || Subgenual Cingulate Cortex || excitatory-glu || uncertain ||(unknown reference)
 
|}
 
|}
  
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{| class=wikitable width=80%
 
{| class=wikitable width=80%
| '''Target Area''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Reference'''
+
| '''Target Area''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Role''' || '''Reference'''
 
|-
 
|-
| [[BrainAreaLAC|LAC]] || [[BrainRegionLAC_HT_BR|LAC.HT.BR]] || Barrington's Nucleus || modulatory-enk || [http://jp.physoc.org/content/557/1/287/F9.expansion.html Schematic overview of spinobulbospinal micturition reflex pathway (PAG -> BAR)]
+
| [[BrainAreaLAC|LAC]] || [[BrainRegionLAC_HT_BR|LAC.HT.BR]] || Barrington's Nucleus || modulatory-enk || uncertain || [http://jp.physoc.org/content/557/1/287/F9.expansion.html Schematic overview of spinobulbospinal micturition reflex pathway (PAG -> BAR)]
 
|-
 
|-
| [[BrainAreaLLC|LLC]] || [[BrainRegionLLC_FD_TH_SF|LLC.FD.TH.SF]] || Subfascicular Nucleus of Thalamus || modulatory-enk || (unknown reference)
+
| [[BrainAreaLLC|LLC]] || [[BrainRegionLLC_FD_TH_SF|LLC.FD.TH.SF]] || Subfascicular Nucleus of Thalamus || modulatory-enk || uncertain || (unknown reference)
 
|-
 
|-
| [[BrainAreaLMC|LMC]] || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || Raphe Magnus Nucleus || modulatory-enk || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (PAG -> Raphe, abstract)]
+
| [[BrainAreaLMC|LMC]] || [[BrainRegionLMC_HL_RP_MG|LMC.HL.RP.MG]] || Raphe Magnus Nucleus || modulatory-enk || uncertain || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (PAG -> Raphe, abstract)]
 
|-
 
|-
|  || [[BrainRegionLMC_HL_RP_PL|LMC.HL.RP.PL]] || Raphe Pallidus Nucleus || modulatory-enk || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (PAG -> Raphe, abstract)]
+
|  || [[BrainRegionLMC_HL_RP_PL|LMC.HL.RP.PL]] || Raphe Pallidus Nucleus || modulatory-enk || uncertain || [http://jn.physiology.org/content/107/10/2633 Connectivity map of the habenula (PAG -> Raphe, abstract)]
 
|-
 
|-
| [[BrainAreaLPC|LPC]] || [[BrainRegionLPC_HL_AMB|LPC.HL.AMB]] || Ambiguus Nucleus || modulatory-enk || (unknown reference)
+
| [[BrainAreaLPC|LPC]] || [[BrainRegionLPC_HL_AMB|LPC.HL.AMB]] || Ambiguus Nucleus || modulatory-enk || uncertain || (unknown reference)
 
|-
 
|-
| [[BrainAreaLRC|LRC]] || [[BrainRegionLRC_HL_RA|LRC.HL.RA]] || Retroambigualis Nucleus || modulatory-enk || (unknown reference)
+
| [[BrainAreaLRC|LRC]] || [[BrainRegionLRC_HL_RA|LRC.HL.RA]] || Retroambigualis Nucleus || modulatory-enk || uncertain || (unknown reference)
 
|-
 
|-
|  || [[BrainRegionLRC_HT_NSC|LRC.HT.NSC]] || Nucleus Subceruleus || modulatory-enk || (unknown reference)
+
|  || [[BrainRegionLRC_HT_NSC|LRC.HT.NSC]] || Nucleus Subceruleus || modulatory-enk || uncertain || (unknown reference)
 
|-
 
|-
| [[BrainAreaNDM|NDM]] || [[BrainRegionNDM_FD_TH_PV|NDM.FD.TH.PV]] || Paraventricular Nucleus of Thalamus || modulatory-enk || (unknown reference)
+
| [[BrainAreaNDM|NDM]] || [[BrainRegionNDM_FD_TH_PV|NDM.FD.TH.PV]] || Paraventricular Nucleus of Thalamus || modulatory-enk || uncertain || (unknown reference)
 
|}
 
|}
  

Latest revision as of 18:29, 28 April 2019

Periaqueductal Gray Matter

@@Home -> BiologicalLifeResearch -> BrainAreaLMC -> BrainRegionLMC_MM_PAG


This page covers biological details of component Periaqueductal Gray Matter. Region is part of aHuman target integrated biological model.

  • Top-down path to region: Midbrain Mesencephalon -> Periaqueductal Gray Matter (LMC.MM.PAG) (see Mind Maps)
  • Type: nucleus
  • Quality: L0
  • Brain area: Lower Brain - Modulatory Contol Area (LMC)
  • Area circuit: Enkephalin - Regulating Nociception in Body (ENK)
  • Role: processor.autonomic
  • Function: Descending modulation of pain and in defensive behaviour
  • Notes to function:
    • if there is a lesion in the PAG, then consciousness is lost
    • electrical stimulation of the PAG results in immediate and profound analgesia
    • modulatory nucleus

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Components

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  • no child items defined

Connectivity

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LMC.MM.PAG.dot.png

Inbound Region Connections:

Source Area Source Region Source Name Type Role Reference
FAM FAM.FT.AM.CEM Medial Central Amygdaloid Nucleus excitatory-glu uncertain Amygdalar disruption of prefrontal cortex (AM -> PAG, abstract)
FEC FEC.HT.TG.IPD Interpeduncular Nucleus modulatory-ach uncertain Connectivity map of the habenula (IPN -> PAG)
NCP NCP.NC.AL.SGCG Subgenual Cingulate Cortex excitatory-glu uncertain (unknown reference)

Outbound Region Connections:

Target Area Target Region Target Name Type Role Reference
LAC LAC.HT.BR Barrington's Nucleus modulatory-enk uncertain Schematic overview of spinobulbospinal micturition reflex pathway (PAG -> BAR)
LLC LLC.FD.TH.SF Subfascicular Nucleus of Thalamus modulatory-enk uncertain (unknown reference)
LMC LMC.HL.RP.MG Raphe Magnus Nucleus modulatory-enk uncertain Connectivity map of the habenula (PAG -> Raphe, abstract)
LMC.HL.RP.PL Raphe Pallidus Nucleus modulatory-enk uncertain Connectivity map of the habenula (PAG -> Raphe, abstract)
LPC LPC.HL.AMB Ambiguus Nucleus modulatory-enk uncertain (unknown reference)
LRC LRC.HL.RA Retroambigualis Nucleus modulatory-enk uncertain (unknown reference)
LRC.HT.NSC Nucleus Subceruleus modulatory-enk uncertain (unknown reference)
NDM NDM.FD.TH.PV Paraventricular Nucleus of Thalamus modulatory-enk uncertain (unknown reference)

Thirdparty Circuits

(generated)

BAR=Barrington's Nucleus,LAC.HT.BR
IMG=Inferior Mesenteric Ganglion,LAC.PN.SYM.IMG
IML=Intermediolateral Nucleus,LAC.SC.IZ.IML
ONF=Onuf's Nucleus,LPC.SC.VH.ONF
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
PEL=Pelvic Peripheral Ganglion,LAC.PN.PSYM.PPG
SPS=Sacral Parasympathetic Nucleus,LAC.SC.IZ.SPS

CPu=Striatum,FEC.FT.ST (see Basal Ganglia)
EP=Endopiriform Nucleus,FAM.FT.EPF
Hippo=Hippocampus,FMM.FT.HC (see Hippocampal Formation)
IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD
L=Lateral Habenula,FAM.FD.LHB (see Habenula)
LH=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN
M=Medial Habenula,FAM.FD.MHB
NAc=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia)
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
Raphe=Raphe Nuclei of Medulla,LMC.HL.RP (see Medullary Reticular Formation)
SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia)
Septum=Septal Nuclei,FAM.FT.SEP
VTA=Ventral Tegmental Area,LMC.MM.VTA

PAG=Periaqueductal Gray Matter,LMC.MM.PAG
VMH=Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM

ACC=Anterior Cingulate Cortex,NC.AL.ACG (see Anterior Cingulate Area)
AMY=Amygdala,FAM.FT.AM
BG=Basal Ganglia,FEC.FT.BG
Cerebellum=Cerebellar Complex,LLC.HT.CRC
Insula=Insular Cortex,NC.INS
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
PB=Parabrachial Nucleus,LPC.HT.PRF.PB
PFC=Prefrontal Cortex,NC.AL.PFC
S1=Primary Somatosensory Cortex,NCP.NC.PG.S1
S2=Secondary Somatosensory Cortex,NCP.NC.PG.S2
SC=Posterior/Dorsal Horn,BMA.SC.PH
Thalamus=Sensory Thalamus,FD.TH.SR

ACC=Anterior Cingulate Cortex,NC.AL.ACG (see Anterior Cingulate Area)
AM=Amygdala,FAM.FT.AM
INS=Insular Cortex,NC.INS
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
PFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
PPC=Superior Parietal Lobule,NC.SPL
S1=Primary Somatosensory Cortex,NCP.NC.PG.S1
SMA=Supplementary Motor Cortex,NMA.NC.SMC
TH=Thalamus,FD.TH

BLN=Parvicellular Basal Amygdaloid Nucleus,FAM.FT.AM.BP
CEA=Central Amygdala,FAM.FT.AM.CEA (see Amygdala)
EC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex)
HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation)
HTS=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN
ITC=Inferotemporal Cortex,NSA.NC.IT.TE
LA=Lateral Amygdaloid Nucleus,FAM.FT.AM.LA (see Amygdala)
LHB=Lateral Habenula,FAM.FD.LHB (see Habenula)
MD=Mediodorsal Nucleus of Thalamus,FD.TH.MD (see Cognitive Thalamus)
MPFC=Orbitomedial Prefrontal Cortex,NC.AL.OMPFC
NACC=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia)
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
RMTG=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG
STC=Wernicke's area A3,NSA.NC.STG.A3
VGDM=Vagus Nucleus,LAC.HL.VGN
VTA=Ventral Tegmental Area,LMC.MM.VTA

ACG=Anterior Cingulate Cortex,NC.AL.ACG (see Anterior Cingulate Area)
AM=Amygdala,FAM.FT.AM
HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation)
HT.L=Lateral Hypothalamic Area,LAC.FD.HT.LT (see Hypothalamus)
HT.PV=Paraventricular Nucleus,LAC.FD.HT.PV
INS=Insular Cortex,NC.INS
LC=Locus Coeruleus,LMC.HT.LC
MPFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
PB=Parabrachial Nucleus,LPC.HT.PRF.PB
PUT=Endocrine Glands,TARGET.TEA.ENDOCRINE
SOL=Solitary Nucleus,LPC.HL.SOL
TH=Thalamus,FD.TH


References

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