BrainRegionLMC MM PAG

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Periaqueductal Gray Matter

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This page covers biological details of component Periaqueductal Gray Matter. Region is part of aHuman target integrated biological model.

  • Top-down path to region: Midbrain Mesencephalon -> Periaqueductal Gray Matter (LMC.MM.PAG) (see Mind Maps)
  • Type: nucleus
  • Brain area: Lower Brain - Modulatory Contol Area
  • Role: relay
  • Function: Descending modulation of pain and in defensive behaviour
  • Notes to function: if there is a lesion in the PAG, then consciousness is lost; electrical stimulation of the PAG results in immediate and profound analgesia; modulatory nucleus

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Components

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Connectivity

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LMC.MM.PAG.dot.png

Inbound Region Connections:

Source Area Source Region Source Name Type Reference
FAM FAM.FT.AM.CEM Medial Central Amygdaloid Nucleus excitatory-glu Amygdalar disruption of prefrontal cortex (AM -> PAG, abstract)
FEC FEC.HT.PPN.IPD Interpeduncular Nucleus modulatory-ach Connectivity map of the habenula (IPN -> PAG)
LAC LAC.FD.HT.VM Ventromedial Hypothalamic Nucleus excitatory-glu Spine induction on short primary dendrites in the ventrolateral VMH (VMH -> PAG)
NCP NCP.NC.AL.SGCG Subgenual Cingulate Cortex excitatory-glu (unknown reference)

Outbound Region Connections:

Target Area Target Region Target Name Type Reference
LAC LAC.HT.BR Barrington's Nucleus modulatory-enk Schematic overview of spinobulbospinal micturition reflex pathway (PAG -> BAR)
LLC LLC.FD.TH.SF Subfascicular Nucleus of Thalamus modulatory-enk (unknown reference)
LMC LMC.HL.RP.MG Raphe Magnus Nucleus modulatory-enk Connectivity map of the habenula (PAG -> Raphe, abstract)
LMC.HL.RP.PL Raphe Pallidus Nucleus modulatory-enk Connectivity map of the habenula (PAG -> Raphe, abstract)
LPC LPC.FD.TH.PV Paraventricular Nucleus of Thalamus modulatory-enk (unknown reference)
LPC.HL.AMB Ambiguus Nucleus modulatory-enk (unknown reference)
LRC LRC.HL.RA Retroambigualis Nucleus modulatory-enk (unknown reference)
LRC.HT.NSC Nucleus Subceruleus modulatory-enk (unknown reference)

Thirdparty Circuits

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References

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