BrainRegionNSA NC STG A3

Wernicke's area A3

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This page covers biological details of component Wernicke's area A3. Region is part of aHuman target integrated biological model.

• Top-down path to region: Cerebral Cortex -> Temporal Lobe (NC.LOBE.TEMP) -> Superior Temporal Gyrus (NC.STG) -> Wernicke's area A3 (NSA.NC.STG.A3) (see Mind Maps)
• Type: cortex
• Quality: L0
• Brain area: Neocortical Brain - Sensory Aggregation Area (NSA)
• Area circuit: Neocortical Audition Aggregation (NAA)
• Brodmann ID: 22
• Role: cortex.generic
• Function: Classify with respect to content
• Notes to function:
  • 22a, Melody perception, sequences of tones

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Components

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• no child items defined

Connectivity

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Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Role	Reference
NSA	NSA.NC.STG.A4	Wernicke's area A4	feedforward-glu	uncertain	Cortical Auditory System (AC22 -> STS22)
	NSA.NC.TTG.A1	Primary Auditory Cortex	feedforward-glu	uncertain	Cortico-Cortical Connectivity (A1 -> AA)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Role	Reference
FAM	FAM.FT.AM.LAVM	Ventromedial Amygdaloid Nucleus	excitatory-glu	uncertain	Amygdala and its network (STC -> LA, abstract)
FMM	FMM.NC.PH.LEC	Lateral Entorhinal Cortex	feedforward-glu	uncertain	(unknown reference)
NCP	NCP.NC.TPC	Temporopolar Cortex	feedforward-glu	uncertain	Language-Related Regions (STG22a -> TC)
NMA	NMA.NC.PMC.F4	Ventral Caudal Premotor Cortex	feedforward-glu	uncertain	Dual Auditory Processing (ST -> VLPFC, abstract)
NPE	NPE.NC.BRA.PT	Broca's Area Pars Triangularis	feedforward-glu	uncertain	Cortical Auditory System (STS22 -> IFC45, abstract)
	NPE.NC.IPL.SMW	Supramarginal Wernike Cortex	feedforward-glu	uncertain	Cortico-Cortical Connectivity (AA -> PTHA, abstract)

Thirdparty Circuits

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• Dual Auditory Processing - see Reference (CP.DUAL-AUDITORY-PROCESSING)

A1=Primary Auditory Cortex,NSA.NC.TTG.A1
DLPFC=Dorsal Premotor Cortex,MCA.NC.DPMC (see Premotor Cortex)
PPC=Supramarginal Gyrus,NC.IPL.SMG (see Inferior Parietal Lobule)
ST=Wernicke's area A3,NSA.NC.STG.A3
VLPFC=Ventral Premotor Cortex,MCA.NC.VPMC (see Premotor Cortex)

• Cortical Auditory System - see Reference (CP.CORTICAL-AUDITORY-SYSTEM)

AC22=Wernicke's area A4,NSA.NC.STG.A4
Belt42=Auditory Association Area,NSA.NC.TTG.A2
Core41=Primary Auditory Cortex,NSA.NC.TTG.A1
IFC44=Broca's Area,NPE.NC.PFC.BRA (see Lateral Prefrontal Cortex)
IFC45=Broca's Area,NPE.NC.PFC.BRA (see Lateral Prefrontal Cortex)
IPL40=Supramarginal Gyrus,NC.IPL.SMG (see Inferior Parietal Lobule)
PMC6=Ventral Premotor Cortex,MCA.NC.VPMC (see Premotor Cortex)
PMC8=Anterior Frontal Eye Field,NPE.NC.PMC.AFEF
STS22=Wernicke's area A3,NSA.NC.STG.A3

• Language-Related Regions - see Reference (CM.LANGUAGE-RELATED-REGIONS)

BA44=Broca's Area,NPE.NC.PFC.BRA (see Lateral Prefrontal Cortex)
BA45=Broca's Area,NPE.NC.PFC.BRA (see Lateral Prefrontal Cortex)
IFG=Broca's Area,NPE.NC.PFC.BRA (see Lateral Prefrontal Cortex)
MTG21=Preoccipital Inferotemporal Area,NSA.NC.IT.TEO
PMC=Premotor Cortex,NC.PMC
STG22a=Wernicke's area A3,NSA.NC.STG.A3
STG22b=Wernicke's area A4,NSA.NC.STG.A4
TC=Temporopolar Cortex,NCP.NC.TPC
pSTC=Wernicke's area A4,NSA.NC.STG.A4
vIFC=Inferior Prefrontal Gyrus,NDM.NC.AL.IPG

• Cortico-Cortical Connectivity - see Reference (CL.CORTICO-CORTICAL-CONNECTIVITY)

A1=Primary Auditory Cortex,NSA.NC.TTG.A1
AA=Wernicke's area A3,NSA.NC.STG.A3
M1=Motor Cortex,NMA.NC.MC
MA=Premotor Cortex,NC.PMC
PFC=Prefrontal Cortex,NC.AL.PFC
PTHA=Inferior Parietal Lobule,NC.IPL
S1=Primary Somatosensory Cortex,NCP.NC.PG.S1
SA=Somatosensory Association Cortex,NCP.NC.SPL.SA
V1=Primary Visual Cortex,NSA.NC.OCC.V1
VA=Secondary Visual Cortex,NSA.NC.OCC.V2 (see Occipital Lobe)

• Amygdala and its network - see Reference (CF.AM-NET)

BLN=Parvicellular Basal Amygdaloid Nucleus,FAM.FT.AM.BP
CEA=Central Amygdala,FAM.FT.AM.CEA (see Amygdala)
EC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex)
HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation)
HTS=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN
ITC=Inferotemporal Cortex,NSA.NC.IT.TE
LA=Lateral Amygdaloid Nucleus,FAM.FT.AM.LA (see Amygdala)
LHB=Lateral Habenula,FAM.FD.LHB (see Habenula)
MD=Mediodorsal Nucleus of Thalamus,FD.TH.MD (see Cognitive Thalamus)
MPFC=Orbitomedial Prefrontal Cortex,NC.AL.OMPFC
NACC=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia)
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
RMTG=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG
STC=Wernicke's area A3,NSA.NC.STG.A3
VGDM=Vagus Nucleus,LAC.HL.VGN
VTA=Ventral Tegmental Area,LMC.MM.VTA

References

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• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846110/
• http://www.nature.com/neuro/journal/v12/n6/fig_tab/nn.2331_F5.html
• http://www.sciencedirect.com/science/article/pii/S1364661312002823
• http://www.sciencedirect.com/science/article/pii/S1053810011000080
• http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=2;spage=40;epage=46;aulast=Langevin