View source for BrainRegionLMC MM PAG


<pre style="color: green">Periaqueductal Gray Matter</pre>
@@[[Home]] -> [[BiologicalLifeResearch]] -> [[BrainAreaLMC]] -> [[BrainRegionLMC_MM_PAG]]
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This page covers biological details of component Periaqueductal Gray Matter.
Region is part of aHuman target integrated biological model.

* '''Top-down path to region''': Midbrain Mesencephalon -> Periaqueductal Gray Matter (LMC.MM.PAG) (see [[OverallMindMaps|Mind Maps]])
* '''Type''': nucleus
* '''Brain area''': [[BrainAreaLMC|Lower Brain - Modulatory Contol Area]]
* '''Role''': relay
* '''Function''': Descending modulation of pain and in defensive behaviour
* '''Notes to function''': if there is a lesion in the PAG, then consciousness is lost; electrical stimulation of the PAG results in immediate and profound analgesia; modulatory nucleus
(generated)
= Components =
(generated)


* no child items defined

= Connectivity =
(generated)


http://ahuman.googlecode.com/svn/images/dot/aHuman/LMC.MM.PAG.dot.png

'''Inbound Region Connections:'''

{| class=wikitable width=80%
| '''Source Area''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Reference''' 
|-
| [[BrainAreaFAM|FAM]] || [[BrainRegionFAM_FT_AM_CEM|FAM.FT.AM.CEM]] || Medial Central Amygdaloid Nucleus || excitatory-glu || [[http://neuropolitics.org/defaultmay10.asp|Amygdalar disruption of prefrontal cortex (AM -> PAG, abstract)]] 
|-
| [[BrainAreaLAC|LAC]] || [[BrainRegionLAC_FD_HT_VM|LAC.FD.HT.VM]] || Ventromedial Hypothalamic Nucleus || excitatory-glu || (unknown reference) 
|-
| [[BrainAreaNCP|NCP]] || [[BrainRegionNCP_NC_AL_SGCG|NCP.NC.AL.SGCG]] || Subgenual Cingulate Cortex || excitatory-glu || (unknown reference) 
|}

'''Outbound Region Connections:'''

{| class=wikitable width=80%
| '''Target Area''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Reference''' 
|-
| [[BrainAreaLAC|LAC]] || [[BrainRegionLAC_HP_BR|LAC.HP.BR]] || Barrington's Nucleus || modulatory-enk || [[http://jp.physoc.org/content/557/1/287/F9.expansion.html|Schematic overview of spinobulbospinal micturition reflex pathway (PAG -> BAR)]] 
|-
| [[BrainAreaLLC|LLC]] || [[BrainRegionLLC_FD_TH_SF|LLC.FD.TH.SF]] || Subfascicular Nucleus of Thalamus || modulatory-enk || (unknown reference) 
|-
| [[BrainAreaLMC|LMC]] || [[BrainRegionLMC_HM_RP_MG|LMC.HM.RP.MG]] || Raphe Magnus Nucleus || modulatory-enk || (unknown reference) 
|-
|  || [[BrainRegionLMC_HM_RP_PL|LMC.HM.RP.PL]] || Raphe Pallidus Nucleus || modulatory-enk || (unknown reference) 
|-
| [[BrainAreaLPC|LPC]] || [[BrainRegionLPC_FD_TH_PV|LPC.FD.TH.PV]] || Paraventricular Nucleus of Thalamus || modulatory-enk || (unknown reference) 
|-
|  || [[BrainRegionLPC_HM_AMB|LPC.HM.AMB]] || Ambiguus Nucleus || modulatory-enk || (unknown reference) 
|-
| [[BrainAreaLRC|LRC]] || [[BrainRegionLRC_HM_RA|LRC.HM.RA]] || Retroambigualis Nucleus || modulatory-enk || (unknown reference) 
|-
|  || [[BrainRegionLRC_HP_PN_SC|LRC.HP.PN.SC]] || Nucleus Subceruleus || modulatory-enk || (unknown reference) 
|}

= Thirdparty Circuits =
(generated)

* [[http://jp.physoc.org/content/557/1/287/F9.large.jpg|Schematic overview of spinobulbospinal micturition reflex pathway]] - see [[http://jp.physoc.org/content/557/1/287/F9.expansion.html|Reference]]

<img src="http://jp.physoc.org/content/557/1/287/F9.large.jpg" alt="unavailable">

* [[http://www.springerimages.com/img/Images/Springer/JOU=10194/VOL=2006.7/ISU=4/ART=2006_307/MediaObjects/MEDIUM_10194_2006_Article_307_Fig1.jpg|Pain matrix]] - see [[http://www.springerimages.com/Images/MedicineAndPublicHealth/1-10.1007_s10194-006-0307-1-0|Reference]]

<img src="http://www.springerimages.com/img/Images/Springer/JOU=10194/VOL=2006.7/ISU=4/ART=2006_307/MediaObjects/MEDIUM_10194_2006_Article_307_Fig1.jpg" alt="unavailable">

* [[http://www.surgicalneurologyint.com/articles/2012/3/2/images/SurgNeurolInt_2012_3_2_40_91609_u1.jpg|Amygdala and its network]] - see [[http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=2;spage=40;epage=46;aulast=Langevin|Reference]]

<img src="http://www.surgicalneurologyint.com/articles/2012/3/2/images/SurgNeurolInt_2012_3_2_40_91609_u1.jpg" alt="unavailable">

* [[http://neuropolitics.org/connect-amygdala.jpg|Amygdalar disruption of prefrontal cortex]] - see [[http://neuropolitics.org/defaultmay10.asp|Reference]]

<img src="http://neuropolitics.org/connect-amygdala.jpg" alt="unavailable">


= References =
(generated)

* http://jp.physoc.org/content/557/1/287/F9.expansion.html
* http://www.springerimages.com/Images/MedicineAndPublicHealth/1-10.1007_s10194-006-0307-1-0
* http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=2;spage=40;epage=46;aulast=Langevin
* http://neuropolitics.org/defaultmay10.asp