Insular Cortex

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This page covers biological details of component group Insular Cortex. Component group is part of aHuman target integrated biological model.

Top-down path to center: Cortex -> Temporal Lobe (NC.LOBE.TEMP) -> Insular Cortex (NC.INS) (see Mind Maps)
Function: Visceral representation, pain, habits
Notes to function: Interoception, merges tactile and auditory streams

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Components

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Component items:

Posterior Insular Cortex: Awareness and sensation of pain
Anterior Insular Cortex: Risky and moral decision making, articulation
Anterior Temporal Lobe: Relaying blood pressure and blood chemistry information to brain
Peripaleocortical Claustral: Relays proprioception

Connectivity

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Internal Regions Connections:

Source Region	Target Region	Reference
Endopiriform Nucleus	Anterior Insular Cortex	Gustatory sensory system of rat and macaque (EnP -> Iav, abstract)
Limitans Nucleus of Thalamus	Peripaleocortical Claustral	Amygdalar disruption of prefrontal cortex (TH -> INS, abstract)
Parabrachial Nucleus	Posterior Insular Cortex	Gustatory sensory system of rat and macaque (PB -> Gud, abstract)
Central Mediodorsal Nucleus of Thalamus	Anterior Insular Cortex	Amygdalar disruption of prefrontal cortex (TH -> INS, abstract)
Posterior Insular Cortex	Anterior Insular Cortex	Gustatory sensory system of rat and macaque (Iav -> IadIap, abstract)
	Peripaleocortical Claustral	Gustatory sensory system of rat and macaque (Iav -> IadIap, abstract)
Temporopolar Cortex	Anterior Insular Cortex	Directed Effort Network (tPole -> Insula, abstract)
Somatosensory Association Cortex	Posterior Insular Cortex	(unknown reference)
Ventral Posteroinferior Nucleus	Posterior Insular Cortex	Pain matrix (TH.VPI -> INS)
Ventral Posterolateral Nucleus	Anterior Temporal Lobe	Amygdalar disruption of prefrontal cortex (TH -> INS, abstract)
Ventral Posteromedial Nucleus	Posterior Insular Cortex	Amygdalar disruption of prefrontal cortex (TH -> INS, abstract)
Piriform Cortex	Anterior Insular Cortex	Gustatory sensory system of rat and macaque (PiR -> Iav, abstract)
Prepyriform Cortex	Anterior Insular Cortex	(unknown reference)

External Inbound Center Connections:

Source Center	Reference
Extended Amygdala	Gustatory sensory system of rat and macaque (EnP -> Iav, abstract)
Thalamus	Amygdalar disruption of prefrontal cortex (TH -> INS, abstract)
Pontine Reticular Formation	Gustatory sensory system of rat and macaque (PB -> Gud, abstract)
Rhinal Cortex	Gustatory sensory system of rat and macaque (PiR -> Iav, abstract)
Superior Parietal Lobule	(unknown reference)
Superior Temporal Gyrus	Directed Effort Network (tPole -> Insula, abstract)

External Outbound Center Connections:

Target Center	Reference
Extended Amygdala	(unknown reference)
Retrosubicular Area	(unknown reference)
Anterior Cingulate Area	Amygdalar disruption of prefrontal cortex (INS -> ACG, abstract)
Prefrontal Cortex	Directed Effort Network (Insula -> fPole, abstract)
Rhinal Cortex	Gustatory sensory system of rat and macaque (Iav -> PrC, abstract)