Difference between revisions of "LGNBiphasicResponses"

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Memory Prediction Research

Home -> SensorsResearch -> VisionResearch -> LGNBiphasicResponses

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  • Article:*
  • Predictive Feedback Can Account for Biphasic Responses in the Lateral Geniculate Nucleus, 2009 - Janneke F. M. Jehee, Dana H. Ballard

Abstract

  • *biphasic neural response* - best response when quick switching between two opposite patterns - detected in LGN, V1, MT
  • article describes: *hierarchical model of predictive coding* and simulations that capture these temporal variations in neuronal response properties
  • focus on the *LGN-V1 circuit*
  • after training on natural images the model exhibits the brain’s LGN-V1 connectivity structure:
* structure of V1 receptive fields is linked to the spatial alignment and properties of center-surround cells in the LGN
* spatio-temporal response profile of LGN model neurons is biphasic in structure, resembling the biphasic response structure of neurons in cat LGN
* model displays a specific pattern of influence of feedback, where LGN receptive fields that are aligned over a simple cell receptive field zone of the same polarity decrease their responses while neurons of opposite polarity increase their responses with feedback
  • predictive feedback is a general coding strategy in the brain

Introduction

  • layout of V1-to-LGN feedback connections follows the structure of LGN-to-V1 feedforward connections
  • LGN cells have center-surround organization
  • LGN regions switch between bright- to dark-excitatory in 20 ms
* what computational reason can change preferred simulus
* biphasic dynamics follow from neural mechanisms of *predictive coding*
  • to be efficient - early-level visual processing removes correlations in the input, resulting in a more sparse and statistically independent output
* early visual areas remove correlations by removing the predictable components in their input
* center-surround structure of LGN receptive fields can be explained using predictive coding mechanisms - center pixel intensity value can be replaced with the difference between the center value and a prediction from a linear weighted sum of its surrounding values
  • works for interaction of lower-order and higher-order visual areas
* low-order and high-order visual areas are reciprocally connected
* higher-level receptive fields represent the predictions of the visual world
* lower-level areas signal the error between predictions and actual visual input
* explains end-stopping

LGN-V1.png

Results

Hierarchical model of predictive coding

  • two layers - LGN and V1
  • Steps
* 1. V1 receives input from LGN
* 2. V1 neuron with receptive field that best matched the input feeds its prediction back to LGN
* 3. LGN neurons compute error between prediction and actual input
* 4. LGN sends error forward to correct prediction
* 5. process is repeated, single feedforward-feedback cycle takes around 20 milliseconds
  • connection weights of the model are adapted to the input by minimizing the description length or entropy of the joint distribution of inputs and neural responses
* minimizes the model’s prediction errors
* improves the sparseness of the neural code
* model converges to a set of connection weights that is optimal for predicting that input

LGN-V1 connectivity structure after training

  • feedforward connection weights from on-center type and off-center type LGN cells coding for the same spatial location are summed for each of the model’s 128 V1 cells
* V1 responses in the model are linear across their on and off inputs
* after training, the receptive fields show orientation tuning as found for simple cells in V1
  • relation between the learned receptive fields in model V1 and the properties of LGN units:
* connections are initially random and are adjusted as a consequence of the model’s learning rule together with exposure to natural images
* after training, on- and off-center units are spatially aligned with the on- and off-zones of the model V1 receptive field

Reversal of polarity due to predictive feedback

  • first consider a *model with non-biphasic inputs*
* spatio-temporal response of model on-center type geniculate cells is calculated using a reverse correlation algorithm
* as in cat LGN, model on-center type receptive fields are arranged in center and surround, and the bright-excitatory phase is followed by a dark-excitatory phase
* removing feedback in the model causes the previously biphasic responses to disappear
  • then model is modified to *simulate biphasic retinal inputs*
* temporal response profile of model on-center type cells is obtained using reverse correlation
* predictive feedback interactions cause reversals of polarity in LGN to be more pronounced than the retinal input
  • why *biphasic responses appear in the mapped model LGN receptive fields*
* reverse correlation leads to visual changes occurring much faster than most natural input the system would encode
* consider stimulus consisting primarily of bright regions
* on-center type LGN cells will respond to the onset of this stimulus
* on zones in the LGN are linked to on zones of receptive fields in V1, which soon start to increase activation and make predictions
* by the time that predictions of the first stimulus arrive in lower-level areas, areas, the initial representation of the bright stimulus has been replaced by a second white noise stimulus, and the prediction is compared against a new and unexpected stimulus representation
* in reverse correlation, predictive processing shows up as a comparison against this running average whitenoise stimulation
* predicted bright region is of higher luminance than the average second stimulus, causing off-center type cells to respond to the offset of the bright reference stimulus
  • reversals in polarity of model LGN cells are most profound in a small time window after presentation of the reference stimulus but disappear gradually later on
* initial prediction is dynamically updated to include predictions of stimuli presented after the reference stimulus
* new predictions are closer to the average white-noise stimulation
* reversals in polarity will appear as long as predictions deviate from the average white-noise stimulation
* precise amount of overlap between prediction and stimulus is not critical
  • simple cell off-zones mediate inhibitory influences to off-center LGN cells and excitatory influences to on-center LGN cells
  • for all model on or off-center LGN receptive fields that are aligned over a V1 receptive field region of the same polarity, firing rates decrease due to feedback
  • where the overlapping fields are of reversed polarity, there is an increase in firing rate
  • neurophysiology: influence of V1 simple cells on LGN on- and off-cells is phase-reversed

Discussion

  • model that encodes an image using predictive feedforward-feedback cycles:
* can learn the brain’s LGNV1 connectivity structure
* structure of V1 receptive fields is linked to the spatial alignment and properties of centersurround cells in the LGN
* captures reversals in polarity of neuronal responses in LGN
* captures phase-reversed pattern of influence from V1 simple cells on LGN cells
  • confirms idea that visual system uses predictive feedforward-feedback interactions to efficiently encode natural input
  • natural visual world is dominated by low temporal frequencies
* retinal image to be relatively stable over the periods of time considered in the model
* under certain conditions visual inputs do change rapidly—more rapidly than most natural inputs the system would encode
  • geniculate cells receive many more feedback connections (~30%) than feedforward connections (~10%)
* feedback signals from V1 affect the response properties of LGN cells
* feedback from V1 seems to affect the strength of center-surround interactions in LGN
* LGN cells respond strongly to bars that are roughly the same size as the center of their receptive field
* responses are attenuated or eliminated when the bar extends beyond the receptive field center (end-stopping)
* this property has been found to depend on feedback signals from V1
  • previous model
* captured endstopping and some other modulations
* predictive feedback model was trained on natural images, in which lines are usually longer rather than shorter
* higher-level receptive fields optimized for representing longer bars
* when presented with shorter bars, the model’s higher-level units could not predict their lower-level input, error responses in the lower-level neurons could not be suppressed
  • in new model the predictive feedback framework also includes rebound effects in LGN
* biphasic responses are stronger in geniculate neurons than in the retinal neurons
* result from predictive feedback interactions, similar to endstopping and some other inhibitory effects
* reversals in polarity have also been described for several cortical areas that do not receive direct input from biphasic retinal cells
  • other explanations of stronger biphasic responses in the LGN
* higher LGN thresholds
* inhibitory feedback from the perigeniculate nucleus
* feedforward inhibition
  • framework features:
* captures biphasic responses and orientation selectivity
* captures phase-reversed influence of cortical feedback to LGN
* explains end-stopping and some other modulations due to surround inhibition in V1 and LGN
* explains reversals in polarity for many areas in cortex
  • computationally advantageous to implement predictive operations through feedback projections
* allow the system to remove redundancy and decorrelate visual responses between areas
* higher-level cortical receptive fields are larger and encode more complex stimuli
* allows predictions of higher complexity and larger regions in the visual field
  • biphasic responses are attenuated in the LGN, or absent in cortex, without cortical feedback
  • model uses subtractive feedback to compare higher-level predictions with actual lower-level input
* could be mediated by, for example, local inhibitory neurons in the same-level area together with long-range excitatory connections from the next higher-level area
  • model could easily be extended to include more cortical areas
* each level would have both coding units and difference detecting units
* coding units predict their lower-level input
* coding units convey the current estimate to the error detectors of the same-level area
* error detectors then signal the difference between their input and its prediction to the next higher level
* finally one prediction becomes dominant in the entire system
  • more accurate higher-level predictions (or equivalently greater overlap between the visual input and higher-level receptive fields) results in reduced activity of lower-level difference detectors
* when top-down predictions in the model are off, lower-level difference detectors enhance their responses
* higher-level coding neurons enhance their activity when stimuli are presented that match their receptive field properties
* subsequent feedforward-feedback passes refine the initial predictions, until finally the entire system settles on the mostly likely interpretation
  • recurrent cycles of processing are less costly in time when the system forms a hierarchy
* most likely predictions are computed first and sent on to higher-level processing areas, which do not have to wait to begin their own computations, enabling initial rapid gist-of-the-scene processing and subsequent feedforward-feedback cycles to fill in the missing details
* some global aspects of a stimulus can be detected very rapidly while detailed aspects are reported later in time
  • top-down signals serve many computational functions
* sparsifying mechanism
* effect of top-down signals in general is not best described as either inhibitory or excitatory
* higher-level areas feed anticipatory signals back to earlier areas, enhancing neural responses to a stimulus that would otherwise fall below threshold
* excitatory interaction between higher-level anticipation and the incoming lower-level signal
* feedback could also act as a bayesian style prior, and adapt early level signals according to different sensory or behavioral conditions
* mechanism presented here should be regarded as a relatively lowlevel mechanism that automatically creates sparser solutions
  • rebound effects are a common feature in reverse correlation mapping and have been described in several visual areas
* biphasic responses have been found for neurons in LGN and V1
* reversals in selectivity in the motion domain have also been found for neurons in MT