BrainRegionFMM FT HC DG

Dentate Gyrus

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This page covers biological details of component Dentate Gyrus. Region is part of aHuman target integrated biological model.

• Top-down path to region: Forebrain Telencephalon -> Hippocampal Formation (HBA.FT.HF) -> Hippocampus (HBA.FT.HC) -> Dentate Gyrus (FMM.FT.HC.DG) (see Mind Maps)
• Type: cortex
• Brain area: Forebrain - Memory Management Area
• Role: processor
• Function: Distinguishing multiple instances of similar events

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Components

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• no child items defined

Connectivity

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Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Reference
FMM	FMM.NC.PH.LEC	Lateral Entorhinal Cortex	excitatory-glu	Neuronal projections in the hippocampus (ET -> DG, abstract)
	FMM.NC.PH.MEC	Medial Entorhinal Cortex	excitatory-glu	Neuronal projections in the hippocampus (ET -> DG, abstract)
	FMM.NC.PH.PER	Perirhinal Cortex	excitatory-glu	Gustatory sensory system of rat and macaque (PrC -> HF, abstract)
LAC	LAC.FD.HT.PN	Posterior Hypothalamic Nucleus	excitatory-glu	(unknown reference)
	LAC.FD.HT.SUM	Supramammillary Nucleus	excitatory-glu	Medial mammillary nucleus and theta rhythm (SupraMM -> HF, abstract)
LRC	LRC.HP.PN.SC	Nucleus Subceruleus	excitatory-glu	(unknown reference)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Reference
FMM	FMM.FT.HC.CA3D	Distal CA3 of Hippocampus	excitatory-glu	Neuronal projections in the hippocampus (DG -> CA3, abstract)
	FMM.FT.HC.CA3M	Middle CA3 of Hippocampus	excitatory-glu	Neuronal projections in the hippocampus (DG -> CA3, abstract)
	FMM.FT.HC.CA3P	Proximal CA3 of Hippocampus	excitatory-glu	Neuronal projections in the hippocampus (DG -> CA3, abstract)

Thirdparty Circuits

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• Simplified model of hippocampal formation anatomy - see Reference

• Combining Novelty, Motivational Salience, and Reward to Control Attention and Learning - see Reference

• KIV model of cortico-hippocampal formation with subcortical projections for motor actions - see Reference

• Hippocampal Formation - see Reference

• Hippocampus in Detail - see Reference

• Principal Connections of Hippocampus - see Reference

• Flow of impulses in hippocampal region - see Reference

• Attractor Network in Hippocampus - see Reference

• Neuronal projections in the hippocampus - see Reference

References

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• http://www.sciencedirect.com/science/article/pii/S030100820900183X
• http://www.impulsecontroldisorders.org/html/cravings.html
• http://www.sciencedirect.com/science/article/pii/S1571064507000243
• article:2009-Hippocampus-Thesis.pdf
• http://what-when-how.com/neuroscience/the-limbic-system-integrative-systems-part-1/
• http://highered.mcgraw-hill.com/sites/dl/free/0071402357/156721/figure350_1.html
• http://www.sciencedirect.com/science/article/pii/S030645220600755X
• http://learnmem.cshlp.org/content/14/11/714/F1.expansion
• http://journal.frontiersin.org/Journal/10.3389/fpsyt.2013.00061/full