Periaqueductal Gray Matter

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This page covers biological details of component Periaqueductal Gray Matter. Region is part of aHuman target integrated biological model.

Top-down path to region: Midbrain Mesencephalon -> Periaqueductal Gray Matter (LMC.MM.PAG) (see Mind Maps)
Type: nucleus
Brain area: Lower Brain - Modulatory Contol Area
Role: processor.autonomic
Function: Descending modulation of pain and in defensive behaviour
Notes to function: if there is a lesion in the PAG, then consciousness is lost; electrical stimulation of the PAG results in immediate and profound analgesia; modulatory nucleus

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Components

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Connectivity

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LMC.MM.PAG.dot.png

Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Reference
FAM	FAM.FT.AM.CEM	Medial Central Amygdaloid Nucleus	excitatory-glu	Amygdalar disruption of prefrontal cortex (AM -> PAG, abstract)
FEC	FEC.HT.PPN.IPD	Interpeduncular Nucleus	modulatory-ach	Connectivity map of the habenula (IPN -> PAG)
LAC	LAC.FD.HT.VM	Ventromedial Hypothalamic Nucleus	excitatory-glu	Spine induction on short primary dendrites in the ventrolateral VMH (VMH -> PAG)
NCP	NCP.NC.AL.SGCG	Subgenual Cingulate Cortex	excitatory-glu	(unknown reference)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Reference
LAC	LAC.HT.BR	Barrington's Nucleus	modulatory-enk	Schematic overview of spinobulbospinal micturition reflex pathway (PAG -> BAR)
LLC	LLC.FD.TH.SF	Subfascicular Nucleus of Thalamus	modulatory-enk	(unknown reference)
LMC	LMC.HL.RP.MG	Raphe Magnus Nucleus	modulatory-enk	Connectivity map of the habenula (PAG -> Raphe, abstract)
	LMC.HL.RP.PL	Raphe Pallidus Nucleus	modulatory-enk	Connectivity map of the habenula (PAG -> Raphe, abstract)
LPC	LPC.FD.TH.PV	Paraventricular Nucleus of Thalamus	modulatory-enk	(unknown reference)
	LPC.HL.AMB	Ambiguus Nucleus	modulatory-enk	(unknown reference)
LRC	LRC.HL.RA	Retroambigualis Nucleus	modulatory-enk	(unknown reference)
	LRC.HT.NSC	Nucleus Subceruleus	modulatory-enk	(unknown reference)