Periaqueductal Gray Matter

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This page covers biological details of component Periaqueductal Gray Matter. Region is part of aHuman target integrated biological model.

*Top-down path to region*: Midbrain Mesencephalon -> Periaqueductal Gray Matter (LMC.MM.PAG) (see Mind Maps)
*Type*: nucleus
*Brain area*: Lower Brain - Modulatory Contol Area
*Role*: relay
*Function*: Descending modulation of pain and in defensive behaviour
*Notes to function*: if there is a lesion in the PAG, then consciousness is lost; electrical stimulation of the PAG results in immediate and profound analgesia; modulatory nucleus

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Components

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Connectivity

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LMC.MM.PAG.dot.png

|| *Source Area* || *Source Region* || *Source Name* || *Type* || *Reference* || || FAM || BrainRegionFAM_FT_AM_CEM FAM.FT.AM.CEM || Medial Central Amygdaloid Nucleus || excitatory-glu || [Amygdalar disruption of prefrontal cortex (AM -> PAG, abstract)] || || LAC || BrainRegionLAC_FD_HT_VM LAC.FD.HT.VM || Ventromedial Hypothalamic Nucleus || excitatory-glu || (unknown reference) || || NCP || BrainRegionNCP_NC_AL_SGCG NCP.NC.AL.SGCG || Subgenual Cingulate Cortex || excitatory-glu || (unknown reference) ||

|| *Target Area* || *Target Region* || *Target Name* || *Type* || *Reference* || || LAC || BrainRegionLAC_HP_BR LAC.HP.BR || Barrington's Nucleus || modulatory-enk || [Schematic overview of spinobulbospinal micturition reflex pathway (PAG -> BAR)] || || LLC || BrainRegionLLC_FD_TH_SF LLC.FD.TH.SF || Subfascicular Nucleus of Thalamus || modulatory-enk || (unknown reference) || || LMC || BrainRegionLMC_HM_RP_MG LMC.HM.RP.MG || Raphe Magnus Nucleus || modulatory-enk || (unknown reference) || || || LMC.HM.RP.PL || Raphe Pallidus Nucleus || modulatory-enk || (unknown reference) || || LPC || BrainRegionLPC_FD_TH_PV LPC.FD.TH.PV || Paraventricular Nucleus of Thalamus || modulatory-enk || (unknown reference) || || || LPC.HM.AMB || Ambiguus Nucleus || modulatory-enk || (unknown reference) || || LRC || BrainRegionLRC_HM_RA LRC.HM.RA || Retroambigualis Nucleus || modulatory-enk || (unknown reference) || || || LRC.HP.PN.SC || Nucleus Subceruleus || modulatory-enk || (unknown reference) ||