Revision as of 09:51, 10 September 2015

Locus Coeruleus

This page covers biological details of component Locus Coeruleus. Region is part of aHuman target integrated biological model.

Top-down path to region: Hindbrain Metencephalon -> Locus Coeruleus (LMC.HT.LC) (see Mind Maps)
Type: nucleus
Brain area: Lower Brain - Modulatory Contol Area
Role: relay
Function: Regulate the intensity of responses to salient stimuli
Notes to function: NE Source, enhance signal-to-noise ratio, suppressing irrelevant stimuli (lateral inhibition); inhibitory nucleus

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Components

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LMC.HT.LC.dot.png

Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Reference
FAM	FAM.FT.AM.CEM	Medial Central Amygdaloid Nucleus	excitatory-glu	Amygdalar disruption of prefrontal cortex (AM -> LC, abstract)
	FAM.FT.BNST	Bed Nucleus of Stria Terminalis	excitatory-glu	(unknown reference)
LAC	LAC.FD.HT.DM	Dorsomedial Hypothalamic Nucleus	excitatory-glu	Effect of light on pupil diameter (DMH -> LC)
	LAC.FD.HT.TBM	Tuberomammillary Nucleus	excitatory-glu	(unknown reference)
LRC	LRC.HL.RF.MED	Central Medullary Reticular Nucleus	excitatory-glu	(unknown reference)
NDM	NDM.NC.AL.VACG	Ventral Anterior Cingulate Area	excitatory-glu	(unknown reference)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Reference
FAM	FAM.FD.LHB.LT	Lateral Habenula Lateral Part	modulatory-ne	Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> LHB, abstract)
	FAM.FD.LHB.MED	Lateral Habenula Medial Part	modulatory-ne	Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> LHB, abstract)
	FAM.FD.MHB	Medial Habenula	modulatory-ne	Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> MHB)
	FAM.FT.SEP.DBB	Diagonal Band of Broca	modulatory-ne	(unknown reference)
FEC	FEC.FT.SNC.MED	Substantia Nigra Pars Compacta Medial	modulatory-ne	(unknown reference)
	FEC.HT.PPN.IPD	Interpeduncular Nucleus	modulatory-ne	Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> IPN)
LAC	LAC.FD.HT.VLPO	Ventrolateral Preoptic Nucleus	modulatory-ne	Simplified NREM sleep-promoting pathway (LC -> VLPO, abstract)
	LAC.SC.IZ.CSC	Ciliospinal Center	modulatory-ne	Effect of light on pupil diameter (LC -> IML)
	LAC.SC.IZ.IML	Intermediolateral Nucleus	modulatory-ne	Physiology and pathophysiology of lower urinary tract (LC -> IML)

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 |  || [[BrainRegionFEC_HT_PPN_IPD|FEC.HT.PPN.IPD]] || Interpeduncular Nucleus || modulatory-ne || [http://www.nature.com/nrn/journal/v11/n6/fig_tab/nrn2849_F7.html Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> IPN)]
 |-
-| [[BrainAreaLAC|LAC]] || [[BrainRegionLAC_FD_HT_PO|LAC.FD.HT.PO]] || Preoptic Nucleus || modulatory-ne || [http://www.nature.com/neuro/journal/v5/n10/fig_tab/nn913_F1.html Simplified NREM sleep-promoting pathway (LC -> VLPO)]
+| [[BrainAreaLAC|LAC]] || [[BrainRegionLAC_FD_HT_VLPO|LAC.FD.HT.VLPO]] || Ventrolateral Preoptic Nucleus || modulatory-ne || [http://www.nature.com/neuro/journal/v5/n10/fig_tab/nn913_F1.html Simplified NREM sleep-promoting pathway (LC -> VLPO, abstract)]
 |-
 |  || [[BrainRegionLAC_SC_IZ_CSC|LAC.SC.IZ.CSC]] || Ciliospinal Center || modulatory-ne || [http://journal.frontiersin.org/article/10.3389/fnint.2012.00094/full Effect of light on pupil diameter (LC -> IML)]