Difference between revisions of "BrainRegionLMC HT LC"

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| [[BrainAreaFEC|FEC]] || [[BrainRegionFEC_FT_SNC_MED|FEC.FT.SNC.MED]] || Substantia Nigra Pars Compacta Medial || modulatory-ne || (unknown reference)
 
| [[BrainAreaFEC|FEC]] || [[BrainRegionFEC_FT_SNC_MED|FEC.FT.SNC.MED]] || Substantia Nigra Pars Compacta Medial || modulatory-ne || (unknown reference)
 
|-
 
|-
|  || [[BrainRegionFEC_HT_PPN_IPD|FEC.HT.PPN.IPD]] || Interpeduncular Nucleus || modulatory-ne || [http://www.nature.com/nrn/journal/v11/n6/fig_tab/nrn2849_F7.html Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> IPN)]
+
|  || [[BrainRegionFEC_HT_TG_IPD|FEC.HT.TG.IPD]] || Interpeduncular Nucleus || modulatory-ne || [http://www.nature.com/nrn/journal/v11/n6/fig_tab/nrn2849_F7.html Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> IPN)]
 
|-
 
|-
 
| [[BrainAreaLAC|LAC]] || [[BrainRegionLAC_FD_HT_VLPO|LAC.FD.HT.VLPO]] || Ventrolateral Preoptic Nucleus || modulatory-ne || [http://www.nature.com/neuro/journal/v5/n10/fig_tab/nn913_F1.html Simplified NREM sleep-promoting pathway (LC -> VLPO)]
 
| [[BrainAreaLAC|LAC]] || [[BrainRegionLAC_FD_HT_VLPO|LAC.FD.HT.VLPO]] || Ventrolateral Preoptic Nucleus || modulatory-ne || [http://www.nature.com/neuro/journal/v5/n10/fig_tab/nn913_F1.html Simplified NREM sleep-promoting pathway (LC -> VLPO)]

Revision as of 09:30, 31 December 2015

Locus Coeruleus

@@Home -> BiologicalLifeResearch -> BrainAreaLMC -> BrainRegionLMC_HT_LC


This page covers biological details of component Locus Coeruleus. Region is part of aHuman target integrated biological model.

  • Top-down path to region: Hindbrain Metencephalon -> Locus Coeruleus (LMC.HT.LC) (see Mind Maps)
  • Type: nucleus
  • Brain area: Lower Brain - Modulatory Contol Area
  • Role: processor.autonomic
  • Function: Regulate the intensity of responses to salient stimuli
  • Notes to function: NE Source, enhance signal-to-noise ratio, suppressing irrelevant stimuli (lateral inhibition); inhibitory nucleus

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Components

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  • no child items defined

Connectivity

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LMC.HT.LC.dot.png

Inbound Region Connections:

Source Area Source Region Source Name Type Reference
FAM FAM.FT.AM.CEM Medial Central Amygdaloid Nucleus excitatory-glu Amygdalar disruption of prefrontal cortex (AM -> LC, abstract)
FAM.FT.BNST Bed Nucleus of Stria Terminalis excitatory-glu (unknown reference)
LAC LAC.FD.HT.DM Dorsomedial Hypothalamic Nucleus excitatory-glu Effect of light on pupil diameter (DMH -> LC)
LAC.FD.HT.TBM Tuberomammillary Nucleus excitatory-glu (unknown reference)
LRC LRC.HL.RF.MED Central Medullary Reticular Nucleus excitatory-glu (unknown reference)
NDM NDM.NC.AL.VACG Ventral Anterior Cingulate Area excitatory-glu (unknown reference)

Outbound Region Connections:

Target Area Target Region Target Name Type Reference
FAM FAM.FD.LHB.LT Lateral Habenula Lateral Part modulatory-ne Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> LHB, abstract)
FAM.FD.LHB.MED Lateral Habenula Medial Part modulatory-ne Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> LHB, abstract)
FAM.FD.MHB Medial Habenula modulatory-ne Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> MHB)
FAM.FT.SEP.DBB Diagonal Band of Broca modulatory-ne (unknown reference)
FEC FEC.FT.SNC.MED Substantia Nigra Pars Compacta Medial modulatory-ne (unknown reference)
FEC.HT.TG.IPD Interpeduncular Nucleus modulatory-ne Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> IPN)
LAC LAC.FD.HT.VLPO Ventrolateral Preoptic Nucleus modulatory-ne Simplified NREM sleep-promoting pathway (LC -> VLPO)
LAC.SC.IZ.CSC Ciliospinal Center modulatory-ne Effect of light on pupil diameter (LC -> IML)
LAC.SC.IZ.IML Intermediolateral Nucleus modulatory-ne Physiology and pathophysiology of lower urinary tract (LC -> IML)

Thirdparty Circuits

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References

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