BrainRegionLMC HT LC

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Locus Coeruleus

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This page covers biological details of component Locus Coeruleus. Region is part of aHuman target integrated biological model.

  • Top-down path to region: Hindbrain Metencephalon -> Locus Coeruleus (LMC.HT.LC) (see Mind Maps)
  • Type: nucleus
  • Brain area: Lower Brain - Modulatory Contol Area
  • Role: relay
  • Function: Regulate the intensity of responses to salient stimuli
  • Notes to function: NE Source, enhance signal-to-noise ratio, suppressing irrelevant stimuli (lateral inhibition); inhibitory nucleus

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Components

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Connectivity

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LMC.HT.LC.dot.png

Inbound Region Connections:

Source Area Source Region Source Name Type Reference
FAM FAM.FT.AM.CEM Medial Central Amygdaloid Nucleus excitatory-glu Amygdalar disruption of prefrontal cortex (AM -> LC, abstract)
FAM.FT.BNST Bed Nucleus of Stria Terminalis excitatory-glu (unknown reference)
LAC LAC.FD.HT.DM Dorsomedial Hypothalamic Nucleus excitatory-glu (unknown reference)
LAC.FD.HT.TBM Tuberomammillary Nucleus excitatory-glu (unknown reference)
LRC LRC.HL.RF.MED Central Medullary Reticular Nucleus excitatory-glu (unknown reference)
NDM NDM.NC.AL.VACG Ventral Anterior Cingulate Area excitatory-glu (unknown reference)

Outbound Region Connections:

Target Area Target Region Target Name Type Reference
FAM FAM.FD.LHB.LT Lateral Habenula Lateral Part modulatory-ne Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> LHB, abstract)
FAM.FD.LHB.MED Lateral Habenula Medial Part modulatory-ne Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> LHB, abstract)
FAM.FD.MHB Medial Habenula modulatory-ne Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> MHB)
FAM.FT.SEP.DBB Diagonal Band of Broca modulatory-ne (unknown reference)
FEC FEC.FT.SNC.MED Substantia Nigra Pars Compacta Medial modulatory-ne (unknown reference)
FEC.HT.PPN.IPD Interpeduncular Nucleus modulatory-ne Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> IPN)
LAC LAC.SC.IZ.IML Intermediolateral Nucleus modulatory-ne Physiology and pathophysiology of lower urinary tract (LC -> IML)

Thirdparty Circuits

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References

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