BrainRegionLMC MM PAG

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Periaqueductal Gray Matter

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This page covers biological details of component Periaqueductal Gray Matter. Region is part of aHuman target integrated biological model.

  • Top-down path to region: Midbrain Mesencephalon -> Periaqueductal Gray Matter (LMC.MM.PAG) (see Mind Maps)
  • Type: nucleus
  • Brain area: Lower Brain - Modulatory Contol Area
  • Role: relay
  • Function: Descending modulation of pain and in defensive behaviour
  • Notes to function: if there is a lesion in the PAG, then consciousness is lost; electrical stimulation of the PAG results in immediate and profound analgesia; modulatory nucleus

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Components

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Connectivity

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LMC.MM.PAG.dot.png

Inbound Region Connections:

Source Area Source Region Source Name Type Reference
FAM FAM.FT.AM.CEM Medial Central Amygdaloid Nucleus excitatory-glu [disruption of prefrontal cortex (AM -> PAG, abstract)]
LAC LAC.FD.HT.VM Ventromedial Hypothalamic Nucleus excitatory-glu (unknown reference)
NCP NCP.NC.AL.SGCG Subgenual Cingulate Cortex excitatory-glu (unknown reference)

Outbound Region Connections:

Target Area Target Region Target Name Type Reference
LAC LAC.HP.BR Barrington's Nucleus modulatory-enk [overview of spinobulbospinal micturition reflex pathway (PAG -> BAR)]
LLC LLC.FD.TH.SF Subfascicular Nucleus of Thalamus modulatory-enk (unknown reference)
LMC LMC.HM.RP.MG Raphe Magnus Nucleus modulatory-enk (unknown reference)
LMC.HM.RP.PL Raphe Pallidus Nucleus modulatory-enk (unknown reference)
LPC LPC.FD.TH.PV Paraventricular Nucleus of Thalamus modulatory-enk (unknown reference)
LPC.HM.AMB Ambiguus Nucleus modulatory-enk (unknown reference)
LRC LRC.HM.RA Retroambigualis Nucleus modulatory-enk (unknown reference)
LRC.HP.PN.SC Nucleus Subceruleus modulatory-enk (unknown reference)

Thirdparty Circuits

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References

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