BrainRegionFAM FT BNST

Bed Nucleus of Stria Terminalis

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This page covers biological details of component Bed Nucleus of Stria Terminalis. Region is part of aHuman target integrated biological model.

• Top-down path to region: Forebrain Telencephalon -> Extended Amygdala (FAM.FT.EXTAM) -> Central Extended Amygdala (FAM.FT.CEAM) -> Bed Nucleus of Stria Terminalis (FAM.FT.BNST) (see Mind Maps)
• Type: nucleus
• Quality: L0
• Brain area: Forebrain - Affective Motivations Area (FAM)
• Area circuit: Express Flight Emotions (FAMXEFL)
• Role: processor.affective.flight
• Function: Mediate slow longer-lasting responses that accompany sustained threats
• Notes to function:
  • Major output from AM to HT, part of extended amygdala
  • medial part continues to medial AM, central part continues to central AM

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Components

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Component items:

• Oval Bed Nucleus of Stria Terminalis
• Lateral Bed Nucleus of Stria Terminalis
• Medial Bed Nucleus of Stria Terminalis

Connectivity

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Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Role	Reference
FAM	FAM.FD.TH.PT	Paratenial Nucleus of Thalamus	excitatory-glu	uncertain	(unknown reference)
	FAM.FT.AM.CEL	Central Amygdaloid Nucleus, lateral subdivision	excitatory-glu	uncertain	(unknown reference)
	FAM.FT.AM.MEA	Medial Anterior Amygdaloid Nucleus	excitatory-glu	uncertain	(unknown reference)
LAC	LAC.FD.HT.VM	Ventromedial Hypothalamic Nucleus	excitatory-glu	uncertain	(unknown reference)
NCP	NCP.NC.AL.SGCG	Subgenual Cingulate Cortex	excitatory-glu	uncertain	(unknown reference)
NDM	NDM.FD.TH.PV	Paraventricular Nucleus of Thalamus	excitatory-glu	uncertain	(unknown reference)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Role	Reference
FAM	FAM.FT.IPAC.MED	Medial Interstitial Anterior Commissural Nucleus	excitatory-glu	uncertain	(unknown reference)
	FAM.FT.SEP.BAC	Bed Nucleus of Anterior Commissure	excitatory-glu	uncertain	(unknown reference)
FEC	FEC.FT.SNC.MED	Substantia Nigra Pars Compacta Medial	excitatory-glu	uncertain	(unknown reference)
LMC	LMC.FT.NBM	Basal Nucleus of Meynert	excitatory-glu	uncertain	(unknown reference)
	LMC.HT.LC	Locus Coeruleus	excitatory-glu	uncertain	(unknown reference)
	LMC.MM.VTA	Ventral Tegmental Area	excitatory-glu	uncertain	(unknown reference)

Thirdparty Circuits

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• Medial prefrontal network - see Reference (CF.DEFAULT-SYSTEM)

BNST=Bed Nucleus of Stria Terminalis,FAM.FT.BNST
MPFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
NACC=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia)
PCG=Posterior Cingulate Cortex,NCP.NC.MPL.PSCG
PH=Parahippocampal Lobe,NC.LOBE.PH
RSP=Retrosplenial Cortex,NCP.NC.MPL.RSC
RostralCtx=Temporopolar Cortex,NCP.NC.TPC
TH.MD=Mediodorsal Nucleus of Thalamus,FD.TH.MD (see Cognitive Thalamus)
TH.PV=Paraventricular Nucleus of Thalamus,NDM.FD.TH.PV
VPAL=Ventral Pallidum,FEC.FT.VP (see Basal Ganglia)

References

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• http://www.nature.com/npp/journal/v35/n1/fig_tab/npp2009104f10.html