BrainRegionLPC SC PH LSG

Lower Substantia Gelatinosa

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This page covers biological details of component Lower Substantia Gelatinosa. Region is part of aHuman target integrated biological model.

• Top-down path to region: Spinal Cord -> Posterior/Dorsal Horn (BMA.SC.PH) -> Lamina II (LPC.SC.PH.L2) -> Substantia Gelatinosa (LPC.SC.PH.SG) -> Lower Substantia Gelatinosa (LPC.SC.PH.LSG) (see Mind Maps)
• Type: nucleus
• Quality: L0
• Brain area: Lower Brain - Peripheral Control Area
• Role: sensory.nucleus
• Function: Relay for C-fibers of slowly conducting, poorly localized pain sensation - T7-T12,L1-L5,S1-S5,CX

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Components

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• no child items defined

Connectivity

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Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Reference
LMC	LMC.HL.RP.MG	Raphe Magnus Nucleus	modulatory-5ht	(unknown reference)
LPC	LPC.PN.SG.LDRG	Lower Dorsal Root Ganglion	excitatory-glu	(unknown reference)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Reference
LPC	LPC.SC.PH.NP	Proprius Nucleus	excitatory-glu	(unknown reference)
NCP	NCP.FD.TH.VPI	Ventral Posteroinferior Nucleus	excitatory-glu	Afferent pain pathways (SC -> Thalamus, abstract)

Thirdparty Circuits

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• Afferent pain pathways - see Reference (CF.PAIN-PATH)

ACC=Anterior Cingulate Cortex,NC.AL.ACG (see Anterior Cingulate Area)
AMY=Amygdala,FAM.FT.AM
BG=Basal Ganglia,FEC.FT.BG
Cerebellum=Cerebellar Complex,LLC.HT.CRC
Insula=Insular Cortex,NC.INS
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
PB=Parabrachial Nucleus,LPC.HT.PRF.PB
PFC=Prefrontal Cortex,NC.AL.PFC
S1=Primary Somatosensory Cortex,NCP.NC.PG.S1
S2=Secondary Somatosensory Cortex,NCP.NC.PG.S2
SC=Posterior/Dorsal Horn,BMA.SC.PH
Thalamus=Sensory Thalamus,FD.TH.SR

References

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• http://www.nature.com/nrn/journal/v14/n7/fig_tab/nrn3516_F2.html