BrainRegionLPC HT PRF PB

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Parabrachial Nucleus

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This page covers biological details of component Parabrachial Nucleus. Region is part of aHuman target integrated biological model.

  • Top-down path to region: Hindbrain Metencephalon -> Pontine Reticular Formation (HT.RF) -> Pontine Reticular Formation, Lateral Column (HT.RF.LAT) -> Parabrachial Nucleus (LPC.HT.PRF.PB) (see Mind Maps)
  • Type: nucleus
  • Brain area: Lower Brain - Peripheral Control Area
  • Role: processor.affective
  • Function: Source of short-latency nociceptive input; sense of physiological condition of body well-being or interoception
  • Notes to function: major relay site for visceral afferents ascending through ventrobasal thalamus and terminating in insular cortex

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Components

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Component items:

  • Subbrachial Nucleus
  • Lateral Parabrachial Nucleus
    • External Lateral Parabrachial Nucleus
  • Medial Parabrachial Nucleus

Connectivity

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LPC.HT.PRF.PB.dot.png

Inbound Region Connections:

Source Area Source Region Source Name Type Reference
FAM FAM.FT.IPAC.MED Medial Interstitial Anterior Commissural Nucleus excitatory-glu (unknown reference)
LPC LPC.HL.SOL Solitary Nucleus excitatory-glu Amygdalar disruption of prefrontal cortex (SOL -> PB)
NCP NCP.NC.AL.SGCG Subgenual Cingulate Cortex excitatory-glu Motor neurons control (CTX -> PRF, abstract)

Outbound Region Connections:

Target Area Target Region Target Name Type Reference
FAM FAM.FT.AM.CEL Central Amygdaloid Nucleus, lateral subdivision excitatory-glu Amygdalar disruption of prefrontal cortex (PB -> AM, abstract)
FEC FEC.FT.ACC.SH Nucleus Accumbens Shell excitatory-glu Bowels control brain: gut hormones and obesity (PBN -> NAc, abstract)
FEC.FT.PU.LT Dorsal Putamen Lateral excitatory-glu Bowels control brain: gut hormones and obesity (PBN -> DS, abstract)
FEC.FT.PU.MED Dorsal Putamen Medial excitatory-glu Bowels control brain: gut hormones and obesity (PBN -> DS, abstract)
LAC LAC.FD.HT.DM Dorsomedial Hypothalamic Nucleus excitatory-glu Food-entrainable circadian oscillator (PBN -> DMH)
LAC.HL.VGN Vagus Nucleus excitatory-glu Physiology and pathophysiology of lower urinary tract (PBN -> DVM)
NCP NCP.FD.TH.VPI Ventral Posteroinferior Nucleus excitatory-glu (unknown reference)
NCP.FD.TH.VPM Ventral Posteromedial Nucleus excitatory-glu Gustatory sensory system of rat and macaque (PB -> VPMpc)
NCP.NC.INS.PIC Posterior Insular Cortex excitatory-glu Gustatory sensory system of rat and macaque (PB -> Gud, abstract)

Thirdparty Circuits

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EnP=Endopiriform Nucleus,FAM.FT.EPF
Gud=Insular Cortex,NC.INS
Gug=Insular Cortex,NC.INS
HF=Hippocampal Formation,FMM.FT.HF
IadIap=Insular Cortex,NC.INS
Iav=Insular Cortex,NC.INS
NST=Solitary Nucleus,LPC.HL.SOL
PB=Parabrachial Nucleus,LPC.HT.PRF.PB
PiR=Piriform Cortex,NSA.NC.PH.PIR
PrC=Perirhinal Cortex,FMM.NC.PH.PER
VPMpc=Ventral Posteromedial Nucleus,NCP.FD.TH.VPM

DMH=Dorsomedial Hypothalamic Nucleus,LAC.FD.HT.DM
LH=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN
NTS=Solitary Nucleus,LPC.HL.SOL
PBN=Parabrachial Nucleus,LPC.HT.PRF.PB
PVH=Paraventricular Nucleus,LAC.FD.HT.PV
SCN=Suprachiasmatic Nucleus,LAC.FD.HT.SCN

AMY=Amygdala,FAM.FT.AM
ARC=Arcuate Nucleus of Hypothalamus,LAC.FD.HT.AR
DS=Dorsal Striatum,FEC.FT.DST (see Basal Ganglia)
LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN
ME=Endocrine Glands,TARGET.TEA.ENDOCRINE
NAc=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia)
NTS=Solitary Nucleus,LPC.HL.SOL
OFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
PBN=Parabrachial Nucleus,LPC.HT.PRF.PB
PVN=Paraventricular Nucleus,LAC.FD.HT.PV
VMN=Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM
VTA=Ventral Tegmental Area,LMC.MM.VTA

CN=Caudate Nucleus,FEC.FT.CN (see Basal Ganglia)
DVM=Vagus Nucleus,LAC.HL.VGN
IMG=Inferior Mesenteric Ganglion,LAC.PN.SYM.IMG
IML=Intermediolateral Nucleus,LAC.SC.IZ.IML
LC=Locus Coeruleus,LMC.HT.LC
MPFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
MPOA=Median Preoptic Nucleus,LAC.FD.HT.MPO
NBM=Basal Nucleus of Meynert,LMC.FT.NBM
ONF=Onuf's Nucleus,LPC.SC.VH.ONF
PBN=Parabrachial Nucleus,LPC.HT.PRF.PB
PEL=Pelvic Peripheral Ganglion,LAC.PN.PSYM.PPG
PU=Dorsal Putamen Lateral,FEC.FT.PU.LT
PVN=Paraventricular Nucleus,LAC.FD.HT.PV
SNC=Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT
SPS=Sacral Parasympathetic Nucleus,LAC.SC.IZ.SPS
VTA=Ventral Tegmental Area,LMC.MM.VTA
ZI=Subthalamic Nucleus Caudal,BGA.FD.STN.ZI

ACG=Anterior Cingulate Cortex,NC.AL.ACG (see Anterior Cingulate Area)
AM=Amygdala,FAM.FT.AM
HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation)
HT.L=Lateral Hypothalamic Area,LAC.FD.HT.LT (see Hypothalamus)
HT.PV=Paraventricular Nucleus,LAC.FD.HT.PV
INS=Insular Cortex,NC.INS
LC=Locus Coeruleus,LMC.HT.LC
MPFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
PB=Parabrachial Nucleus,LPC.HT.PRF.PB
PUT=Endocrine Glands,TARGET.TEA.ENDOCRINE
SOL=Solitary Nucleus,LPC.HL.SOL
TH=Thalamus,FD.TH

ACC=Anterior Cingulate Cortex,NC.AL.ACG (see Anterior Cingulate Area)
AMY=Amygdala,FAM.FT.AM
BG=Basal Ganglia,FEC.FT.BG
Cerebellum=Cerebellar Complex,LLC.HT.CRC
Insula=Insular Cortex,NC.INS
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
PB=Parabrachial Nucleus,LPC.HT.PRF.PB
PFC=Prefrontal Cortex,NC.AL.PFC
S1=Primary Somatosensory Cortex,NCP.NC.PG.S1
S2=Secondary Somatosensory Cortex,NCP.NC.PG.S2
SC=Posterior/Dorsal Horn,BMA.SC.PH
Thalamus=Sensory Thalamus,FD.TH.SR


References

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