BrainRegionLMC MM VTA

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Ventral Tegmental Area

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This page covers biological details of component Ventral Tegmental Area. Region is part of aHuman target integrated biological model.

  • Top-down path to region: Midbrain Mesencephalon -> Ventral Tegmental Area (LMC.MM.VTA) (see Mind Maps)
  • Type: nucleus
  • Brain area: Lower Brain - Modulatory Contol Area
  • Role: relay
  • Function: Respond to novel stimuli, unexpected rewards, and reward predictive sensory cues

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Components

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Component items:

  • Medial Ventral Tegmental Area
  • Parabrachial Pigmented Area
  • Paranigral Nucleus
  • Parafasciculus Retroflexus Area
  • Raphe Nucleus Linearis (LMC.HP.RP.LI): Release of 5-HT was only obtained on stimulation of this nucleus
    • Rostral Linear Nucleus

Connectivity

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LMC.MM.VTA.dot.png

Inbound Region Connections:

Source Area Source Region Source Name Type Reference
FAM FAM.FT.BNST Bed Nucleus of Stria Terminalis excitatory-glu (unknown reference)
FEC FEC.FT.ACC.CORE Nucleus Accumbens Core inhibitory-gaba [circuit of human brain (NACC -> VTA, abstract)]
LMC LMC.HP.TG.VTG Ventral Tegmental Nucleus excitatory-glu (unknown reference)

Outbound Region Connections:

Target Area Target Region Target Name Type Reference
FAM FAM.FT.AM.CEC Central Amygdaloid Nucleus, capsular subdivision modulatory-da [circuit of human brain (VTA -> AM, abstract)]
FEC FEC.FT.ACC.SH Nucleus Accumbens Shell modulatory-da [(VTA -> NACC, abstract)]
FMM FMM.FD.MB.MMB Medial Mammillary Nucleus modulatory-da [bodies: two memory systems in one (VTN -> MMB)]
FMM.FT.HC.CA1D Distal CA1 of Hippocampus modulatory-da [circuit of human brain (VTA -> HC, abstract)]
FMM.NC.PH.LEC Lateral Entorhinal Cortex modulatory-da [Novelty, Motivational Salience, and Reward to Control Attention and Learning (VTA -> EC, abstract)]
LAC LAC.FD.HT.PO Preoptic Nucleus modulatory-da [and pathophysiology of lower urinary tract (VTA -> MPOA)]
LAC.FD.HT.PRM Premammillary Nucleus modulatory-da (unknown reference)
LAC.FD.HT.PV Paraventricular Nucleus modulatory-da [and pathophysiology of lower urinary tract (VTA -> PVN)]
NDM NDM.NC.AL.DACG Dorsal Anterior Cingulate Area modulatory-da (unknown reference)
NDM.NC.AL.FPC Lateral Frontopolar Cortex modulatory-da [circuit of human brain (VTA -> PFC, abstract)]

Thirdparty Circuits

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References

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