BrainRegionFEC FT SNC LT

Substantia Nigra Pars Compacta Lateral

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This page covers biological details of component Substantia Nigra Pars Compacta Lateral. Region is part of aHuman target integrated biological model.

• Top-down path to region: Forebrain Telencephalon -> Basal Ganglia (FEC.FT.BG) -> Substantia Nigra (FEC.FT.SN) -> Substantia Nigra Pars Compacta (FEC.FT.SNC) -> Substantia Nigra Pars Compacta Lateral (FEC.FT.SNC.LT) (see Mind Maps)
• Type: nucleus
• Brain area: Forebrain - Execution Control Area
• Role: relay
• Function: executive loop
• Notes to function: DP, dorsal circuits

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Components

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• no child items defined

Connectivity

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Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Reference
FAM	FAM.FD.LHB.MED	Lateral Habenula Medial Part	excitatory-glu	Habenula Connections (LHb -> SNc, abstract)
FEC	FEC.FT.CN.HD	Caudate Nucleus Head	inhibitory-gaba	Saccades and smooth movements (CN -> SN, abstract)
	FEC.FT.GPI.DS	Globus Pallidus Internal Dorsal	inhibitory-gaba	Prefrontal Cortex (PFC) in motor behavior (GP -> SN, abstract)
	FEC.FT.SNR.DL	Substantia Nigra Pars Reticulata Dorsolateral	inhibitory-gaba	Oculomotor decision-making (SNr -> SNc)
	FEC.FT.SNR.RM	Substantia Nigra Pars Reticulata Rostromedial	inhibitory-gaba	(unknown reference)
	FEC.HT.PPN.IPD	Interpeduncular Nucleus	modulatory-ach	(unknown reference)
LRC	LRC.MM.SC.DEEP	Deep Superior Colliculus	excitatory-glu	Global visual system (SCi -> SNc, abstract)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Reference
FEC	FEC.FT.ACC.SH	Nucleus Accumbens Shell	modulatory-da	Global visual system (SNc -> Striatum, abstract)
	FEC.FT.PU.LT	Dorsal Putamen Lateral	modulatory-da	Physiology and pathophysiology of lower urinary tract (SNC -> PU)
	FEC.FT.PU.MED	Dorsal Putamen Medial	modulatory-da	Basal Ganglia Activity (SN -> PU, abstract)
LLC	LLC.HT.CR.CC	Cerebrocerebellum	modulatory-da	Prefrontal Cortex (PFC) in motor behavior (SN -> CR, abstract)
	LLC.MM.RD	Red Nucleus	modulatory-da	(unknown reference)

Thirdparty Circuits

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• Saccadic Vision - see Reference

• Global visual system - see Reference

• Prefrontal Cortex (PFC) in motor behavior - see Reference

• Physiology and pathophysiology of lower urinary tract - see Reference

• Basal Ganglia Activity - see Reference

• Oculomotor decision-making - see Reference

• Normal Functional Anatomy of Basal Ganglia - see Reference

• Habenula Connections - see Reference

References

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• http://www.nature.com/nrn/journal/v5/n3/box/nrn1345_BX1.html
• http://www.sciencedirect.com/science/article/pii/S0959438808001566
• https://www.google.ru/search?hl=rutbo=ptbm=bksq=isbn:0080887988
• http://www.intechopen.com/books/computational-intelligence-in-electromyography-analysis-a-perspective-on-current-applications-and-future-challenges/sphincter-emg-for-diagnosing-multiple-system-atrophy-and-related-disorders
• http://thebrain.mcgill.ca/flash/a/a_06/a_06_cr/a_06_cr_mou/a_06_cr_mou.html
• http://www.springerimages.com/Images/LifeSciences/1-10.1007_s00359-004-0565-9-0
• http://www.mdvu.org/library/disease/pd/par_path.asp
• http://www.scholarpedia.org/article/Habenula