BrainRegionLMC MM VTA

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Ventral Tegmental Area

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This page covers biological details of component Ventral Tegmental Area. Region is part of aHuman target integrated biological model.

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Components

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Component items:

  • Medial Ventral Tegmental Area
  • Parabrachial Pigmented Area
  • Paranigral Nucleus
  • Parafasciculus Retroflexus Area
  • Raphe Nucleus Linearis (LMC.HP.RP.LI): Release of 5-HT was only obtained on stimulation of this nucleus
    • Rostral Linear Nucleus

Connectivity

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LMC.MM.VTA.dot.png

Inbound Region Connections:

Source Area Source Region Source Name Type Reference
FAM FAM.FT.BNST Bed Nucleus of Stria Terminalis excitatory-glu (unknown reference)
FAM.HP.PPN.RMTG Rostromedial Tegmental Nucleus inhibitory-gaba Amygdala and its network (RMTG -> VTA)
FEC FEC.FT.ACC.CORE Nucleus Accumbens Core inhibitory-gaba Reward circuit of human brain (NACC -> VTA, abstract)
LMC LMC.HP.TG.VTG Ventral Tegmental Nucleus excitatory-glu (unknown reference)

Outbound Region Connections:

Target Area Target Region Target Name Type Reference
FAM FAM.FT.AM.CEC Central Amygdaloid Nucleus, capsular subdivision modulatory-da Reward circuit of human brain (VTA -> AM, abstract)
FEC FEC.FT.ACC.SH Nucleus Accumbens Shell modulatory-da Craving (VTA -> NACC, abstract)
FMM FMM.FD.MB.MMB Medial Mammillary Nucleus modulatory-da Mammillary bodies: two memory systems in one (VTN -> MMB)
FMM.FT.HC.CA1D Distal CA1 of Hippocampus modulatory-da Reward circuit of human brain (VTA -> HC, abstract)
FMM.NC.PH.LEC Lateral Entorhinal Cortex modulatory-da Combining Novelty, Motivational Salience, and Reward to Control Attention and Learning (VTA -> EC, abstract)
LAC LAC.FD.HT.PO Preoptic Nucleus modulatory-da Physiology and pathophysiology of lower urinary tract (VTA -> MPOA)
LAC.FD.HT.PRM Premammillary Nucleus modulatory-da (unknown reference)
LAC.FD.HT.PV Paraventricular Nucleus modulatory-da Physiology and pathophysiology of lower urinary tract (VTA -> PVN)
NDM NDM.NC.AL.DACG Dorsal Anterior Cingulate Area modulatory-da (unknown reference)
NDM.NC.AL.FPC Lateral Frontopolar Cortex modulatory-da Amygdala and its network (VTA -> MPFC, abstract)

Thirdparty Circuits

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References

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