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Ventromedial Prefrontal Cortex

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This page covers biological details of component Ventromedial Prefrontal Cortex. Region is part of aHuman target integrated biological model.

  • Top-down path to region: Cerebral Cortex -> Anterior Lobe (NC.LOBE.ANT) -> Prefrontal Cortex (NC.AL.PFC) -> Orbitomedial Prefrontal Cortex (NC.AL.OMPFC) -> Medial Prefrontal Cortex (NC.AL.MPFC) -> Ventromedial Prefrontal Cortex (NDM.NC.AL.VMPFC) (see Mind Maps)
  • Type: cortex
  • Quality: L0
  • Brain area: Neocortical Brain - Decision Making Area (NDM)
  • Area circuit: Motivatory Associations (MAS)
  • Brodmann ID: 11
  • Role: cortex.generic
  • Function: Ongoing Introverted Attention with Regard to Emotions and Feelings, Reward or Punishment
  • Notes to function:
    • lower MPFC, primary connections to limbic and sensory cortices
    • Reward mediated behaviours




  • no child items defined



Inbound Region Connections:

Source Area Source Region Source Name Type Role Reference
FAM FAM.FT.SEP.DBB Diagonal Band of Broca inhibitory-gaba uncertain (unknown reference)
FMM FMM.FT.HC.CA1D Distal CA1 of Hippocampus excitatory-glu uncertain Gating of medial prefrontal activity by the entorhinal cortex (HC -> MPFC, abstract)
NDM NDM.FD.TH.PV Paraventricular Nucleus of Thalamus excitatory-glu uncertain Saccadic Vision (Thalamus -> FrontalCortex, abstract)
NDM.NC.AL.DLPFCR Rostral Mid-Dorsolateral Prefrontal Cortex feedforward-glu uncertain Fear regulation (dlPFC -> vmPFC, abstract)

Outbound Region Connections:

Target Area Target Region Target Name Type Role Reference
FAM FAM.FT.AM.ITC Intercalated Amygdaloid Nuclei excitatory-glu uncertain (unknown reference)
FAM.FT.AM.LADL Dorsolateral Amygdaloid Nucleus excitatory-glu uncertain (unknown reference)

Thirdparty Circuits


B=Basal Amygdaloid Nucleus,FAM.FT.AM.B (see Amygdala)
CE=Central Amygdala,FAM.FT.AM.CEA (see Amygdala)
Hippocampus=Hippocampus,FMM.FT.HC (see Hippocampal Formation)
ITC=Intercalated Amygdaloid Nuclei,FAM.FT.AM.ITC
LA=Lateral Amygdaloid Nucleus,FAM.FT.AM.LA (see Amygdala)
Striatum=Striatum,FEC.FT.ST (see Basal Ganglia)
dlPFC=Mid-Dorsolateral Prefrontal Cortex,NDM.NC.AL.DLPFC (see Lateral Prefrontal Cortex)
vmPFC=Ventromedial Prefrontal Cortex,NDM.NC.AL.VMPFC