BrainRegionFAM FT SEP SF

Septofimbrial Nucleus

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This page covers biological details of component Septofimbrial Nucleus. Region is part of aHuman target integrated biological model.

• Top-down path to region: Forebrain Telencephalon -> Extended Amygdala (FAM.FT.EXTAM) -> Septal Nuclei (FAM.FT.SEP) -> Posterior Septal Group (FAM.FT.SEP.PG) -> Septofimbrial Nucleus (FAM.FT.SEP.SF) (see Mind Maps)
• Type: nucleus
• Brain area: Forebrain - Affective Motivations Area
• Role: processor.affective.conscious
• Function: afferent to medial habenula, primary input to indirect encoding negative feedback

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Components

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• no child items defined

Connectivity

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Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Reference
FAM	FAM.HT.TG.NI	Incertus Nucleus	inhibitory-gaba	(unknown reference)
FMM	FMM.FT.HC.CA3D	Distal CA3 of Hippocampus	excitatory-glu	Connectivity map of the habenula (Hippo -> Septum, abstract)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Reference
FAM	FAM.FD.MHB	Medial Habenula	inhibitory-gaba	Connectivity map of the habenula (Septum -> M, abstract)

Thirdparty Circuits

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• Medial mammillary nucleus and theta rhythm - see Reference

map: 
AVTH=Anteroventral Nucleus,FMM.FD.TH.AV
HF=Hippocampal Formation,FMM.FT.HF
MMB=Medial Mammillary Nucleus,FMM.FD.MB.MMB
RSP=Retrosplenial Cortex,NCP.NC.MPL.RSC
SEP=Septal Nuclei,FAM.FT.SEP
SupraMM=Supramammillary Nucleus,LAC.FD.HT.SUM
VTN=Ventral Tegmental Area,LMC.MM.VTA

• Connectivity map of the habenula - see Reference

map: 
CPu=Striatum,FEC.FT.ST (see Basal Ganglia)
EP=Endopiriform Nucleus,FAM.FT.EPF
Hippo=Hippocampus,FMM.FT.HC (see Hippocampal Formation)
IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD
L=Lateral Habenula,FAM.FD.LHB (see Habenula)
LH=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN
M=Medial Habenula,FAM.FD.MHB
NAc=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia)
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
Raphe=Raphe Nuclei of Medulla,LMC.HL.RP (see Medullary Reticular Formation)
SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia)
Septum=Septal Nuclei,FAM.FT.SEP
VTA=Ventral Tegmental Area,LMC.MM.VTA

References

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• http://www.nature.com/nrn/journal/v5/n1/fig_tab/nrn1299_F4.html
• http://jn.physiology.org/content/107/10/2633