BrainRegionLMC MM RP DRN

Dorsal Raphe Nucleus

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This page covers biological details of component Dorsal Raphe Nucleus. Region is part of aHuman target integrated biological model.

• Top-down path to region: Midbrain Mesencephalon -> Mesencephalic Reticular Formation (MM.RF) -> Mesencephalic Reticular Formation, Midline Column (MM.RF.MID) -> Dorsal Raphe Nucleus (LMC.MM.RP.DRN) (see Mind Maps)
• Type: nucleus
• Brain area: Lower Brain - Modulatory Contol Area
• Role: relay
• Function: Regulation of sleep and mood
• Notes to function: Major source of 5HT; inhibitory nucleus

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Components

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Component items:

• Serotonergic cell group B7

Connectivity

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Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Reference
FAM	FAM.FD.LHB.MED	Lateral Habenula Medial Part	excitatory-glu	Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> DRN)
FEC	FEC.HT.PPN.IPD	Interpeduncular Nucleus	modulatory-ach	Both LHb and MHb control the dopaminergic and serotonergic systems (IPN -> DRN)
	FEC.HT.PPN.RMTG	Rostromedial Tegmental Nucleus	inhibitory-gaba	Both LHb and MHb control the dopaminergic and serotonergic systems (RMTg -> DRN)
LLC	LLC.FD.TH.SF	Subfascicular Nucleus of Thalamus	inhibitory-gaba	(unknown reference)
LMC	LMC.HP.RP.LI	Raphe Nucleus Linearis	modulatory-5ht	(unknown reference)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Reference
LPC	LPC.FD.TH.PV	Paraventricular Nucleus of Thalamus	modulatory-5ht	(unknown reference)

Thirdparty Circuits

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• Both LHb and MHb control the dopaminergic and serotonergic systems - see Reference

• Habenula Connections - see Reference

References

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• http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html
• http://www.scholarpedia.org/article/Habenula