BrainRegionLMC MM RP DRN

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Dorsal Raphe Nucleus

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This page covers biological details of component Dorsal Raphe Nucleus. Region is part of aHuman target integrated biological model.

  • Top-down path to region: Midbrain Mesencephalon -> Mesencephalic Reticular Formation (MM.RF) -> Mesencephalic Reticular Formation, Midline Column (MM.RF.MID) -> Dorsal Raphe Nucleus (LMC.MM.RP.DRN) (see Mind Maps)
  • Type: nucleus
  • Quality: L0
  • Brain area: Lower Brain - Modulatory Contol Area (LMC)
  • Area circuit: Serotonin - Feelings of Well-Being and Happiness (5HT)
  • Role: processor.autonomic
  • Function: Regulation of sleep and mood
  • Notes to function:
    • Major source of 5HT
    • inhibitory nucleus




Component items:

  • Serotonergic cell group B7



Inbound Region Connections:

Source Area Source Region Source Name Type Role Reference
FAM FAM.FD.LHB.MED Lateral Habenula Medial Part excitatory-glu uncertain Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> DRN)
FEC FEC.HT.TG.IPD Interpeduncular Nucleus modulatory-ach uncertain Both LHb and MHb control the dopaminergic and serotonergic systems (IPN -> DRN)
FEC.HT.TG.RMTG Rostromedial Tegmental Nucleus inhibitory-gaba uncertain Both LHb and MHb control the dopaminergic and serotonergic systems (RMTg -> DRN)
LLC LLC.FD.TH.SF Subfascicular Nucleus of Thalamus inhibitory-gaba uncertain (unknown reference)
LMC LMC.HP.RP.LI Raphe Nucleus Linearis modulatory-5ht uncertain (unknown reference)

Outbound Region Connections:

Target Area Target Region Target Name Type Role Reference
NDM NDM.FD.TH.PV Paraventricular Nucleus of Thalamus modulatory-5ht uncertain (unknown reference)

Thirdparty Circuits


DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB
DRN=Dorsal Raphe Nucleus,LMC.MM.RP.DRN
GPb=Dorsal Pallidum,FEC.FT.DP (see Basal Ganglia)
IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD
LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN
LHbL=Lateral Habenula Lateral Part,FAM.FD.LHB.LT
LHbM=Lateral Habenula Medial Part,FAM.FD.LHB.MED
LPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO
LS=Lateral Septal Nucleus,FAM.FT.SEP.LT
MHb=Medial Habenula,FAM.FD.MHB
MRN=Raphe Nuclei of Medulla,LMC.HL.RP (see Medullary Reticular Formation)
MS=Medial Septal Nucleus,FAM.FT.SEP.MED
PS=Posterior Septal Group,FAM.FT.SEP.PG (see Septal Nuclei)
RMTg=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG
SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia)
VP=Ventral Pallidum,FEC.FT.VP (see Basal Ganglia)
VTA=Ventral Tegmental Area,LMC.MM.VTA

CPu=Striatum,FEC.FT.ST (see Basal Ganglia)
DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB
DR=Dorsal Raphe Nucleus,LMC.MM.RP.DRN
GPi=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia)
IP=Interpeduncular Nucleus,FEC.HT.TG.IPD
LH=Lateral Hypothalamic Area,LAC.FD.HT.LT (see Hypothalamus)
LHb=Lateral Habenula,FAM.FD.LHB (see Habenula)
LPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO
MHb=Medial Habenula,FAM.FD.MHB
MR=Superior Central Raphe Nucleus,LMC.MM.RP.SUC
S=Septal Nuclei,FAM.FT.SEP
SNc=Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT
VTA=Ventral Tegmental Area,LMC.MM.VTA