BrainRegionFAM FT SEP LT

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Lateral Septal Nucleus

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This page covers biological details of component Lateral Septal Nucleus. Region is part of aHuman target integrated biological model.

  • Top-down path to region: Forebrain Telencephalon -> Extended Amygdala (FAM.FT.EXTAM) -> Septal Nuclei (FAM.FT.SEP) -> Dorsal Septal Nucleus (FAM.FT.SEP.DS) -> Lateral Septal Group (FAM.FT.SEP.LG) -> Lateral Septal Nucleus (FAM.FT.SEP.LT) (see Mind Maps)
  • Type: nucleus
  • Quality: L0
  • Brain area: Forebrain - Affective Motivations Area (FAM)
  • Area circuit: Solving Fight-Flight Dilemma (FAMXFFD)
  • Role: processor.affective
  • Function: promote active stress coping behavior




  • no child items defined



Inbound Region Connections:

Source Area Source Region Source Name Type Role Reference
FAM FAM.FT.AM.CEM Medial Central Amygdaloid Nucleus excitatory-glu uncertain (unknown reference)
FAM.FT.AM.MPV Medial Posterior Ventral Amygdaloid Nucleus inhibitory-gaba uncertain (unknown reference)
FMM FMM.FT.HC.CA1D Distal CA1 of Hippocampus excitatory-glu uncertain Connectivity map of the habenula (Hippo -> Septum, abstract)
LAC LAC.FD.HT.PN Posterior Hypothalamic Nucleus excitatory-glu uncertain (unknown reference)
LAC.FD.HT.TBM Tuberomammillary Nucleus excitatory-glu uncertain (unknown reference)
LMC LMC.MM.RP.SUC Superior Central Raphe Nucleus modulatory-5ht uncertain (unknown reference)

Outbound Region Connections:

Target Area Target Region Target Name Type Role Reference
FAM FAM.FD.LHB.MED Lateral Habenula Medial Part inhibitory-gaba uncertain Both LHb and MHb control the dopaminergic and serotonergic systems (LS -> LHbM)
LAC LAC.FD.HT.VLPO Ventrolateral Preoptic Nucleus inhibitory-gaba uncertain Cingulate Gyrus (SEP -> HT, abstract)
NDM NDM.FD.TH.PV Paraventricular Nucleus of Thalamus inhibitory-gaba uncertain (unknown reference)

Thirdparty Circuits


AVTH=Anteroventral Nucleus,FMM.FD.TH.AV
HF=Hippocampal Formation,FMM.FT.HF
MMB=Medial Mammillary Nucleus,FMM.FD.MB.MMB
RSP=Retrosplenial Cortex,NCP.NC.MPL.RSC
SEP=Septal Nuclei,FAM.FT.SEP
SupraMM=Supramammillary Nucleus,LAC.FD.HT.SUM
VTN=Ventral Tegmental Area,LMC.MM.VTA

CG=Posterior Cingulate Cortex,NCP.NC.MPL.PSCG
ET=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex)
HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation)
MB=Mammillary Body,FD.MB (see Hypothalamus)
SEP=Septal Nuclei,FAM.FT.SEP
TH=Anterior Nucleus of Thalamus,FD.TH.AN (see Cognitive Thalamus)

DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB
DRN=Dorsal Raphe Nucleus,LMC.MM.RP.DRN
GPb=Dorsal Pallidum,FEC.FT.DP (see Basal Ganglia)
IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD
LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN
LHbL=Lateral Habenula Lateral Part,FAM.FD.LHB.LT
LHbM=Lateral Habenula Medial Part,FAM.FD.LHB.MED
LPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO
LS=Lateral Septal Nucleus,FAM.FT.SEP.LT
MHb=Medial Habenula,FAM.FD.MHB
MRN=Raphe Nuclei of Medulla,LMC.HL.RP (see Medullary Reticular Formation)
MS=Medial Septal Nucleus,FAM.FT.SEP.MED
PS=Posterior Septal Group,FAM.FT.SEP.PG (see Septal Nuclei)
RMTg=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG
SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia)
VP=Ventral Pallidum,FEC.FT.VP (see Basal Ganglia)
VTA=Ventral Tegmental Area,LMC.MM.VTA