BrainRegionLAC FD HT DM

Dorsomedial Hypothalamic Nucleus

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This page covers biological details of component Dorsomedial Hypothalamic Nucleus. Region is part of aHuman target integrated biological model.

• Top-down path to region: Forebrain Diencephalon -> Hypothalamus (FD.HT) -> Posterior Hypothalamic Area (LAC.FD.HT.POS) -> Dorsomedial Hypothalamic Nucleus (LAC.FD.HT.DM) (see Mind Maps)
• Type: nucleus
• Brain area: Lower Brain - Autonomous Control Area
• Role: processor.autonomic
• Function: Blood pressure, heart rate

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Components

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• no child items defined

Connectivity

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Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Reference
FAM	FAM.FT.AM.BP	Parvicellular Basal Amygdaloid Nucleus	excitatory-glu	Role for serotonin in moral behavior (AMY -> HYP, abstract)
LAC	LAC.FD.HT.AH	Anterior Hypothalamic Nucleus	excitatory-glu	Intrahypothalamic connections important for neural control of food intake and energy balance (AH -> DMN)
	LAC.FD.HT.AR	Arcuate Nucleus of Hypothalamus	excitatory-glu	Intrahypothalamic connections important for neural control of food intake and energy balance (ARC -> DMN)
	LAC.FD.HT.SCN	Suprachiasmatic Nucleus	excitatory-glu	Intrahypothalamic connections important for neural control of food intake and energy balance (SCH -> DMN)
	LAC.FD.HT.VM	Ventromedial Hypothalamic Nucleus	excitatory-glu	Intrahypothalamic connections important for neural control of food intake and energy balance (VMN -> DMN)
LPC	LPC.HL.SOL	Solitary Nucleus	excitatory-glu	Food-entrainable circadian oscillator (NTS -> DMH)
	LPC.HT.PRF.PB	Parabrachial Nucleus	excitatory-glu	Food-entrainable circadian oscillator (PBN -> DMH)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Reference
LAC	LAC.FD.HT.LTN	Lateral Hypothalamic Nucleus	excitatory-glu	Eating and sleeping to survive (DMH -> LHA)
	LAC.FD.HT.MPO	Median Preoptic Nucleus	excitatory-glu	Eating and sleeping to survive (DMH -> MPO)
	LAC.FD.HT.PV	Paraventricular Nucleus	excitatory-glu	Eating and sleeping to survive (DMH -> PVH)
	LAC.FD.HT.VLPO	Ventrolateral Preoptic Nucleus	excitatory-glu	Eating and sleeping to survive (DMH -> VLPO)
LMC	LMC.HT.LC	Locus Coeruleus	excitatory-glu	Effect of light on pupil diameter (DMH -> LC)

Thirdparty Circuits

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• Schematic of hypothalamic circuitry underlying satiety - see Reference

map: ARC=Arcuate Nucleus of Hypothalamus,LAC.FD.HT.AR, DMH=Dorsomedial Hypothalamic Nucleus,LAC.FD.HT.DM, LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN, NTS=Solitary Nucleus,LPC.HL.SOL, PVN=Paraventricular Nucleus,LAC.FD.HT.PV, VMH=Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM

• Eating and sleeping to survive - see Reference

map: ARC=Arcuate Nucleus of Hypothalamus,LAC.FD.HT.AR, DMH=Dorsomedial Hypothalamic Nucleus,LAC.FD.HT.DM, LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN, MPO=Median Preoptic Nucleus,LAC.FD.HT.MPO, PVH=Paraventricular Nucleus,LAC.FD.HT.PV, SCN=Suprachiasmatic Nucleus,LAC.FD.HT.SCN, VLPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO, VMH=Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM

• Effect of light on pupil diameter - see Reference

map: DMH=Dorsomedial Hypothalamic Nucleus,LAC.FD.HT.DM, EW=Edinger-Westphal Nucleus,LAC.MM.EWN, EYE=Eye,TARGET.TSA.EYE, GC=Ciliary Ganglion,LAC.PN.PSYM.CLG, IML=Ciliospinal Center,LAC.SC.IZ.CSC, LC=Locus Coeruleus,LMC.HT.LC, OPN=Pretectal Olivary Nucleus,LRC.MM.PT.PON, PVN=Paraventricular Nucleus,LAC.FD.HT.PV, RET=Retinal Nucleus,LPC.FD.RT, SCG=Superior Cervical Ganglion,LAC.PN.SYM.SCG, SCN=Suprachiasmatic Nucleus,LAC.FD.HT.SCN

• Glucose-sensing neural network - see Reference

map: ARC=Arcuate Nucleus of Hypothalamus,LAC.FD.HT.AR, DMN=Dorsomedial Hypothalamic Nucleus,LAC.FD.HT.DM, LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN, PVH=Paraventricular Nucleus,LAC.FD.HT.PV, VMH=Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM

• Food-entrainable circadian oscillator - see Reference

map: DMH=Dorsomedial Hypothalamic Nucleus,LAC.FD.HT.DM, LH=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN, NTS=Solitary Nucleus,LPC.HL.SOL, PBN=Parabrachial Nucleus,LPC.HT.PRF.PB, PVH=Paraventricular Nucleus,LAC.FD.HT.PV, SCN=Suprachiasmatic Nucleus,LAC.FD.HT.SCN

• Intrahypothalamic connections important for neural control of food intake and energy balance - see Reference

map: AH=Anterior Hypothalamic Nucleus,LAC.FD.HT.AH, ARC=Arcuate Nucleus of Hypothalamus,LAC.FD.HT.AR, DMN=Dorsomedial Hypothalamic Nucleus,LAC.FD.HT.DM, LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN, MPOA=Median Preoptic Nucleus,LAC.FD.HT.MPO, PA=Paraventricular Nucleus,LAC.FD.HT.PV, SCH=Suprachiasmatic Nucleus,LAC.FD.HT.SCN, SON=Supraoptic Nucleus,LAC.FD.HT.SO, VMN=Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM

References

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• http://neuroscience.uth.tmc.edu/s4/chapter04.html
• http://www.dana.org/Publications/ReportDetails.aspx?id=44217
• http://journal.frontiersin.org/article/10.3389/fnint.2012.00094/full
• http://ajpregu.physiology.org/content/302/2/R215
• http://www.pnas.org/content/103/32/12150/F7.expansion.html
• http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.122.2314rep=rep1type=pdf