BrainCenterLLC HT CRC

Cerebellar Complex

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This page covers biological details of component group Cerebellar Complex. Component group is part of aHuman target integrated biological model.

• Top-down path to center: Hindbrain Metencephalon -> Cerebellar Complex (LLC.HT.CRC) (see Mind Maps)
• Function:

(generated)

Components

(generated)

Component items:

• Cerebellum (LLC.HT.CR): Motor coordination
  • Cerebellar Flocconodular Lobe (LRC.HT.CR.FN): regulates balance
  • Cerebellar Lateral Lobe (LLC.HT.CR.CC): planning movement that is about to occur, evaluating sensory information for action, handles intentions
  • Spinocerebellum (LLC.HT.CR.SC)
    • Cerebellar Paravermis (LLC.HT.CR.PV): fine-tune body and limb movements
    • Cerebellar Vermis (LRC.HT.CR.VM): balance and spatial orientation, gait
• Deep Cerebellar Nuclei (LLC.HT.CR.DCN)
  • Dentate Nucleus (LLC.HT.CR.DN): planning, initiation and control of voluntary movements
  • Interposed Nucleus (LLC.HT.CR.IP): coordinating agonist/antagonist muscle pairs
    • Emboliform Nucleus (LLC.HT.CR.EN): Modulate motor functions of Red Nucleus
    • Globose Nucleus (LLC.HT.CR.GN): Modulate motor functions of Red Nucleus
  • Fastigual Nucleus (LRC.HT.CR.FG): rostral - interprets body motion and places it on spatial planes to estimate movement of body through space; caudal - saccadic eye movements
• Basilar Pontine Nuclei (LLC.HT.BPN): convey information from motor cortex to cerebellum regarding intended movements of contralateral arm and leg

Connectivity

(generated)

Internal Regions Connections:

Source Region	Target Region	Reference
Basilar Pontine Nuclei (LLC.HT.BPN)	Cerebellar Lateral Lobe (LLC.HT.CR.CC)	Cerebellum functional divisions (PNN -> CRP)
Cerebellar Lateral Lobe (LLC.HT.CR.CC)	Dentate Nucleus (LLC.HT.CR.DN)	Cerebellum functional divisions (CRP -> DN)
Dentate Nucleus (LLC.HT.CR.DN)	Globose Nucleus (LLC.HT.CR.GN)	(unknown reference)
Emboliform Nucleus (LLC.HT.CR.EN)	Globose Nucleus (LLC.HT.CR.GN)	(unknown reference)
Cerebellar Paravermis (LLC.HT.CR.PV)	Emboliform Nucleus (LLC.HT.CR.EN)	Cerebellum functional divisions (CRS -> IP, abstract)
	Globose Nucleus (LLC.HT.CR.GN)	Cerebellum functional divisions (CRS -> IP, abstract)
	Fastigual Nucleus (LRC.HT.CR.FG)	Cerebellum functional divisions (CRS -> FG)
Cerebellar Vermis (LRC.HT.CR.VM)	Fastigual Nucleus (LRC.HT.CR.FG)	Cerebellum functional divisions (CRV -> FG)

External Connections:

External Inbound Center Connections:

Source Center	Sample Link	Reference
Posterior/Dorsal Horn (BMA.SC.PH)	LPC.SC.PH.CL -> LLC.HT.CR.PV	Afferent pain pathways (SC -> Cerebellum, abstract)
Basal Ganglia (FEC.FT.BG)	FEC.FT.SNC.LT -> LLC.HT.CR.CC	Prefrontal Cortex (PFC) in motor behavior (SN -> CR, abstract)
Medullary Reticular Formation (HL.RF)	LLC.HL.RF.MLRN -> LLC.HT.CR.PV	(unknown reference)
Myelencephalic Sensory Nuclei (HL.SN)	LLC.HL.IO -> LLC.HT.CR.CC	Cerebellum functional divisions (IO -> CRP)
Pontine Reticular Formation (HT.RF)	LRC.HT.PRF.RPO -> LLC.HT.CR.CC	Saccades and smooth movements (DLPN -> CR, abstract)
Metencephalic Sensory Nuclei (HT.SN)	LLC.HT.PN.RSP -> LLC.HT.CR.DN	Prefrontal Cortex (PFC) in motor behavior (PN -> CR, abstract)
Vestibular Nuclei (LPC.HT.VBN)	LPC.HT.IVBN -> LRC.HT.CR.FN	(unknown reference)
Vestibular Ganglion (LPC.PN.SG.VB)	LPC.PN.SG.SVB -> LRC.HT.CR.FN	(unknown reference)
Motor Cortex (NMA.NC.MC)	NMA.NC.MC -> LLC.HT.BPN	Cerebellum functional divisions (CTX -> PNN, abstract)
Intermediate Zone (SC.IZ)	LPC.SC.IZ.CCV -> LLC.HT.CR.PV	Cerebellum functional divisions (CCV -> CRS)

External Outbound Center Connections:

Target Center	Sample Link	Reference
Cognitive Thalamus (FD.TH.CR)	LLC.HT.CR.DN -> NCP.FD.TH.RIL	(unknown reference)
Motor Thalamus (FD.TH.MR)	LLC.HT.CR.DN -> NMA.FD.TH.VL	Thalamocortical relationships (s1VL -> VL)
Pontine Reticular Formation (HT.RF)	LRC.HT.CR.FG -> LRC.HT.PRF.CRF	Cerebellum functional divisions (FG -> RF, abstract)
Red Nucleus (LLC.MM.RD)	LLC.HT.CR.DN -> LLC.MM.RD	Motor neurons control (LT -> RD)
Vestibular Nuclei (LPC.HT.VBN)	LRC.HT.CR.FG -> LPC.HT.LVBN	Cerebellum functional divisions (FG -> VB, abstract)
Reflexes Nuclei of Midbrain Mesencephalon (MM.REF)	LLC.HT.BPN -> LRC.MM.SC.INT	(unknown reference)
Lateral Prefrontal Cortex (NC.AL.LPFC)	LLC.HT.CR.DN -> NDM.NC.AL.DLPFCL	(unknown reference)