Paraventricular Nucleus

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This page covers biological details of component Paraventricular Nucleus. Region is part of aHuman target integrated biological model.

Top-down path to region: Forebrain Diencephalon -> Hypothalamus (FD.HT) -> Anterior Hypothalamus Area (LAC.FD.HT.AHT) -> Tuberal Area (LAC.FD.HT.TUB) -> Paraventricular Nucleus (LAC.FD.HT.PV) (see Mind Maps)
Type: nucleus
Brain area: Lower Brain - Autonomous Control Area
Role: relay
Function: Regulate appetite and autonomic functions

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Components

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Component items:

Paraventricular Nucleus of Hypothalamus Magnocellular Division
- Paraventricular Nucleus of Hypothalamus Magnocellular Division - Anterior Magnocellular Part
- Paraventricular Nucleus of Hypothalamus Magnocellular Division - Medial Magnocellular Part
- Paraventricular Nucleus of Hypothalamus Magnocellular Division - Posterior Magnocellular Part
  - Paraventricular Nucleus of Hypothalamus Magnocellular Division - Posterior Magnocellular Part Lateral Zone
  - Paraventricular Nucleus of Hypothalamus Magnocellular Division - Posterior Magnocellular Part Medial Zone
Paraventricular Nucleus of Hypothalamus Parvicellular Division
Paraventricular Nucleus of Hypothalamus Descending Division
- Paraventricular Nucleus of Hypothalamus Descending Division - Dorsal Parvicellular Part
- Paraventricular Nucleus of Hypothalamus Descending Division - Forniceal Part
- Paraventricular Nucleus of Hypothalamus Descending Division - Lateral Parvicellular Part
- Paraventricular Nucleus of Hypothalamus Descending Division - Medial Parvicellular Part, Ventral Zone

Connectivity

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LAC.FD.HT.PV.dot.png

Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Reference
FAM	FAM.FT.AM.MPD	Medial Posterior Dorsal Amygdaloid Nucleus	inhibitory-gaba	Amygdalar disruption of prefrontal cortex (AM -> HT.PV, abstract)
FMM	FMM.FT.HF.SUBD	Distal Subiculum	excitatory-glu	(unknown reference)
LAC	LAC.FD.HT.AR	Arcuate Nucleus of Hypothalamus	excitatory-glu	Intrahypothalamic connections important for neural control of food intake and energy balance (ARC -> PA)
	LAC.FD.HT.DM	Dorsomedial Hypothalamic Nucleus	excitatory-glu	Intrahypothalamic connections important for neural control of food intake and energy balance (DMN -> PA)
	LAC.FD.HT.LTN	Lateral Hypothalamic Nucleus	excitatory-glu	Schematic of hypothalamic circuitry underlying satiety (LHA -> PVN)
	LAC.FD.HT.PO	Preoptic Nucleus	excitatory-glu	Intrahypothalamic connections important for neural control of food intake and energy balance (MPOA -> PA)
	LAC.FD.HT.SCN	Suprachiasmatic Nucleus	excitatory-glu	Food-entrainable circadian oscillator (SCN -> PVH)
	LAC.FD.HT.VM	Ventromedial Hypothalamic Nucleus	excitatory-glu	Glucose-sensing neural network (VMH -> PVH)
LMC	LMC.MM.VTA	Ventral Tegmental Area	modulatory-da	Physiology and pathophysiology of lower urinary tract (VTA -> PVN)
LPC	LPC.HL.SOL	Solitary Nucleus	excitatory-glu	(unknown reference)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Reference
LAC	LAC.FD.HT.DM	Dorsomedial Hypothalamic Nucleus	excitatory-glu	Schematic of hypothalamic circuitry underlying satiety (PVN -> DMH)
	LAC.SC.CC.DCN	Dorsal Commissural Nucleus	excitatory-glu	(unknown reference)
	LAC.SC.IZ.SPS	Sacral Parasympathetic Nucleus	excitatory-glu	(unknown reference)
	LAC.SC.LH.LSN	Lateral Spinal Nucleus	excitatory-glu	(unknown reference)
LMC	LMC.HL.RP.MG	Raphe Magnus Nucleus	excitatory-glu	(unknown reference)
LPC	LPC.SC.VH.ONF	Onuf's Nucleus	excitatory-glu	(unknown reference)
NDM	NDM.NC.AL.ROFCS	Sulcal Rostral Orbitofrontal Cortex	excitatory-glu	Bowels control brain: gut hormones and obesity (PVN -> OFC, abstract)
TEA	TARGET.TEA.ENDOCRINE	Endocrine Glands	endocrine-neurohypophysis-oxytocin	Amygdalar disruption of prefrontal cortex (HT.PV -> PUT)