BrainCenterFAM FD HB

Habenula

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This page covers biological details of component group Habenula. Component group is part of aHuman target integrated biological model.

• Top-down path to center: Forebrain Diencephalon -> Habenula (FAM.FD.HB) (see Mind Maps)
• Function: Encoding negative feedback

(generated)

Components

(generated)

Component items:

• Lateral Habenula (FAM.FD.LHB): Encoding negative feedback, direct; motivational control of behavior; pain processing, reward, motivation, and learning
  • Lateral Habenula Medial Part (FAM.FD.LHB.MED): Encoding negative feedback, direct, Septal
  • Lateral Habenula Lateral Part (FAM.FD.LHB.LT): Encoding negative feedback, direct, Pallidal
• Medial Habenula (FAM.FD.MHB): Encoding negative feedback, indirect

Connectivity

(generated)

Internal Regions Connections:

Source Region	Target Region	Reference
Medial Habenula (FAM.FD.MHB)	Lateral Habenula Medial Part (FAM.FD.LHB.MED)	(unknown reference)

External Connections:

External Inbound Center Connections:

Source Center	Reference
Septal Nuclei (FAM.FT.SEP)	Both LHb and MHb control the dopaminergic and serotonergic systems (LS -> LHbM)
Hypothalamus (FD.HT)	Habenula Connections (LPO -> LHb, abstract)
Basal Ganglia (FEC.FT.BG)	Habenula Connections (GPi -> LHb, abstract)
Pontine Tegmental Nuclei (HT.TG)	(unknown reference)
Locus Coeruleus (LMC.HT.LC)	(unknown reference)
Mesencephalic Reticular Formation (MM.RF)	(unknown reference)

External Outbound Center Connections:

Target Center	Reference
Basal Ganglia (FEC.FT.BG)	Habenula Connections (LHb -> SNc, abstract)
Medullary Reticular Formation (HL.RF)	Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> MRN, abstract)
Pontine Tegmental Nuclei (HT.TG)	Both LHb and MHb control the dopaminergic and serotonergic systems (LHbL -> RMTg)
Ventral Tegmental Area (LMC.MM.VTA)	Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> VTA)
Mesencephalic Reticular Formation (MM.RF)	Habenula Connections (LHb -> MR, abstract)
Endocrine Glands (TARGET.TEA.ENDOCRINE)	Habenula Connections (MHb -> PB)