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Substantia Nigra Pars Reticulata Medial

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This page covers biological details of component Substantia Nigra Pars Reticulata Medial. Region is part of aHuman target integrated biological model.

  • Top-down path to region: Forebrain Telencephalon -> Basal Ganglia (FEC.FT.BG) -> Substantia Nigra (FEC.FT.SN) -> Substantia Nigra Pars Reticulata (FEC.FT.SNR) -> Substantia Nigra Pars Reticulata Medial (FEC.FT.SNR.MED) (see Mind Maps)
  • Type: nucleus
  • Brain area: Forebrain - Execution Control Area
  • Role: basal.ganglia.nigrareticulata
  • Function: Motivational loop




  • no child items defined



Inbound Region Connections:

Source Area Source Region Source Name Type Reference
FEC FEC.FD.STN.DL Subthalamic Nucleus Dorsolateral excitatory-glu (unknown reference)
FEC.FT.ACC.CORE Nucleus Accumbens Core inhibitory-gaba Craving (NACC -> SNr, abstract)
FEC.FT.CN.TL Caudate Nucleus Tail inhibitory-gaba Saccades and smooth movements (CN -> SN, abstract)
FEC.FT.GPE.RM Globus Pallidus External Rostromedial inhibitory-gaba Prefrontal Cortex (PFC) in motor behavior (GP -> SN, abstract)
FEC.FT.PU.VT Ventral Putamen inhibitory-gaba (unknown reference)
FEC.FT.VP.DL Ventral Pallidum Dorsolateral inhibitory-gaba Craving (VPAL -> SNr, abstract)
NDM NDM.NC.AL.FPC Lateral Frontopolar Cortex excitatory-glu Global visual system (FrontalCortex -> BGA, abstract)

Outbound Region Connections:

Target Area Target Region Target Name Type Reference
FEC FEC.FT.SNC.MED Substantia Nigra Pars Compacta Medial inhibitory-gaba (unknown reference)
FEC.HT.TG.IPD Interpeduncular Nucleus inhibitory-gaba (unknown reference)
NMA NMA.FD.TH.MDL Lateral Mediodorsal Nucleus of Thalamus inhibitory-gaba Saccadic Vision (BG -> Thalamus, abstract)

Thirdparty Circuits


BG=Basal Ganglia,FEC.FT.BG
CN=Caudate Nucleus,FEC.FT.CN (see Basal Ganglia)
CR=Cerebellum,LLC.HT.CR (see Cerebellar Complex)
FrontalCortex=Anterior Lobe,NC.LOBE.ANT
GPe=Globus Pallidus External,FEC.FT.GPE (see Basal Ganglia)
LGN=Lateral Geniculate Nucleus,NSA.FD.LGN
LIP=Lateral Intraparietal Sulcus,NPE.NC.IPS.LIP
RF=Pontine Reticular Formation,HT.RF
Retina=Retinal Nucleus,LPC.FD.RT
SCi=Superior Colliculus,MM.SC (see Reflexes Nuclei of Midbrain Mesencephalon)
SCs=Superior Colliculus,MM.SC (see Reflexes Nuclei of Midbrain Mesencephalon)
SNpr=Substantia Nigra Pars Reticulata Dorsolateral,FEC.FT.SNR.DL
STN=Subthalamic Nucleus,FEC.FD.STN (see Subthalamus Area)
VisualCortex=Occipital Lobe,NC.LOBE.OCC

NACC=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia)
OMPFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
SNr=Substantia Nigra Pars Reticulata Medial,FEC.FT.SNR.MED
VPAL=Ventral Pallidum,FEC.FT.VP (see Basal Ganglia)
VTA=Ventral Tegmental Area,LMC.MM.VTA