Lateral Frontopolar Cortex

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This page covers biological details of component Lateral Frontopolar Cortex. Region is part of aHuman target integrated biological model.

Top-down path to region: Cerebral Cortex -> Anterior Lobe (NC.LOBE.ANT) -> Prefrontal Cortex (NC.AL.PFC) -> Orbitomedial Prefrontal Cortex (NC.AL.OMPFC) -> Orbitofrontal Cortex (NC.AL.OPFC) -> Lateral Frontopolar Cortex (NDM.NC.AL.FPC) (see Mind Maps)
Type: cortex
Brain area: Neocortical Brain - Decision Making Area
Brodmann ID: 10
Role: processor
Function: Emotion Regulation
Notes to function: Frontopolar area, contains ILC - infralimbic cortex

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Components

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Connectivity

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Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Reference
LMC	LMC.FT.NBM	Basal Nucleus of Meynert	modulatory-ach	Physiology and pathophysiology of lower urinary tract (NBM -> MPFC, abstract)
	LMC.MM.VTA	Ventral Tegmental Area	modulatory-da	Amygdala and its network (VTA -> MPFC, abstract)
NCP	NCP.NC.INS.PPC	Peripaleocortical Claustral	feedforward-glu	Amygdalar disruption of prefrontal cortex (INS -> MPFC, abstract)
NDM	NDM.FD.TH.MDM	Medial Mediodorsal Nucleus of Thalamus	excitatory-glu	Amygdala and its network (MD -> MPFC, abstract)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Reference
FAM	FAM.FT.AM.BM	Magnocellular Basal Amygdaloid Nucleus	excitatory-glu	(unknown reference)
	FAM.FT.AM.BP	Parvicellular Basal Amygdaloid Nucleus	excitatory-glu	Amygdala and its network (MPFC -> BLN, abstract)
	FAM.FT.SEP.SH	Septohippocampal Nucleus	excitatory-glu	(unknown reference)
FEC	FEC.FT.ACC.CORE	Nucleus Accumbens Core	excitatory-glu	Affective basal ganglia circuit (OMPFC -> NACC, abstract)
	FEC.FT.SNR.MED	Substantia Nigra Pars Reticulata Medial	excitatory-glu	Global visual system (FrontalCortex -> BGA, abstract)
LAC	LAC.FD.HT.RCH	Retrochiasmatic Nucleus	excitatory-glu	Prefrontal Cortex (PFC) in emotional behavior (OPFC -> HT, abstract)
NDM	NDM.NC.AL.DLPFCR	Rostral Mid-Dorsolateral Prefrontal Cortex	feedforward-glu	Prefrontal Cortex (PFC) in emotional behavior (OPFC -> LPFC, abstract)
	NDM.NC.AL.VACG	Ventral Anterior Cingulate Area	feedforward-glu	Role for serotonin in moral behavior (OMPFC -> ACG, abstract)