BrainRegionLMC HL RP MG

Raphe Magnus Nucleus

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This page covers biological details of component Raphe Magnus Nucleus. Region is part of aHuman target integrated biological model.

• Top-down path to region: Hindbrain Myelencephalon -> Medullary Reticular Formation (HL.RF) -> Medullary Reticular Formation, Midline Column (HL.RF.MID) -> Raphe Nuclei of Medulla (LMC.HL.RP) -> Raphe Magnus Nucleus (LMC.HL.RP.MG) (see Mind Maps)
• Type: nucleus
• Brain area: Lower Brain - Modulatory Contol Area
• Role: relay
• Function: Inhubit head and spinal pain
• Notes to function: B3, contacts with enkephalenic neurons in substantia gelatinosa

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Components

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Connectivity

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Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Reference
FAM	FAM.FD.LHB.MED	Lateral Habenula Medial Part	excitatory-glu	Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> MRN, abstract)
FEC	FEC.HT.PPN.IPD	Interpeduncular Nucleus	modulatory-ach	Both LHb and MHb control the dopaminergic and serotonergic systems (IPN -> MRN, abstract)
	FEC.HT.PPN.RMTG	Rostromedial Tegmental Nucleus	inhibitory-gaba	Both LHb and MHb control the dopaminergic and serotonergic systems (RMTg -> MRN, abstract)
LAC	LAC.FD.HT.LTN	Lateral Hypothalamic Nucleus	excitatory-glu	(unknown reference)
	LAC.FD.HT.PV	Paraventricular Nucleus	excitatory-glu	(unknown reference)
LLC	LLC.MM.SCNF	Subcuneiform Nucleus	excitatory-glu	(unknown reference)
LMC	LMC.MM.PAG	Periaqueductal Gray Matter	modulatory-enk	(unknown reference)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Reference
LPC	LPC.SC.PH.LSG	Lower Substantia Gelatinosa	modulatory-5ht	(unknown reference)
	LPC.SC.PH.USG	Upper Substantia Gelatinosa	modulatory-5ht	(unknown reference)

Thirdparty Circuits

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References

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• no references defined