Difference between revisions of "BrainRegionLPC HT PRF PB"

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* '''Top-down path to region''': Hindbrain Metencephalon -> [[BrainCenterHT_RF|Pontine Reticular Formation]] (HT.RF) -> Pontine Reticular Formation, Lateral Column (HT.RF.LAT) -> [[BrainRegionLPC_HT_PRF_PB|Parabrachial Nucleus]] (LPC.HT.PRF.PB) (see [[OverallMindMaps|Mind Maps]])
 
* '''Top-down path to region''': Hindbrain Metencephalon -> [[BrainCenterHT_RF|Pontine Reticular Formation]] (HT.RF) -> Pontine Reticular Formation, Lateral Column (HT.RF.LAT) -> [[BrainRegionLPC_HT_PRF_PB|Parabrachial Nucleus]] (LPC.HT.PRF.PB) (see [[OverallMindMaps|Mind Maps]])
 
* '''Type''': nucleus
 
* '''Type''': nucleus
−
* '''Brain area''': [[BrainAreaLPC|Lower Brain - Peripheral Control Area]]
+
* '''Quality''': L0
 +
* '''Brain area''': [[BrainAreaLPC|Lower Brain - Peripheral Control Area]] (LPC)
 +
* '''Area circuit''': Pain Sensations (SP)
 
* '''Role''': processor.affective
 
* '''Role''': processor.affective
 
* '''Function''': Source of short-latency nociceptive input; sense of physiological condition of body well-being or interoception
 
* '''Function''': Source of short-latency nociceptive input; sense of physiological condition of body well-being or interoception
−
* '''Notes to function''': major relay site for visceral afferents ascending through ventrobasal thalamus and terminating in insular cortex
+
* '''Notes to function''':  
 +
** major relay site for visceral afferents ascending through ventrobasal thalamus and terminating in insular cortex
 
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= Components =
 
= Components =
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{| class=wikitable width=80%
 
{| class=wikitable width=80%
−
| '''Source Area''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Reference'''
+
| '''Source Area''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Role''' || '''Reference'''
 
|-
 
|-
−
| [[BrainAreaFAM|FAM]] || [[BrainRegionFAM_FT_IPAC_MED|FAM.FT.IPAC.MED]] || Medial Interstitial Anterior Commissural Nucleus || excitatory-glu || (unknown reference)
+
| [[BrainAreaFAM|FAM]] || [[BrainRegionFAM_FT_IPAC_MED|FAM.FT.IPAC.MED]] || Medial Interstitial Anterior Commissural Nucleus || excitatory-glu || uncertain ||(unknown reference)
 
|-
 
|-
−
| [[BrainAreaLPC|LPC]] || [[BrainRegionLPC_HL_SOL|LPC.HL.SOL]] || Solitary Nucleus || excitatory-glu || [http://neuropolitics.org/defaultmay10.asp Amygdalar disruption of prefrontal cortex (SOL -> PB)]
+
| [[BrainAreaLPC|LPC]] || [[BrainRegionLPC_HL_SOL|LPC.HL.SOL]] || Solitary Nucleus || excitatory-glu || uncertain ||[http://neuropolitics.org/defaultmay10.asp Amygdalar disruption of prefrontal cortex (SOL -> PB)]
 
|-
 
|-
−
| [[BrainAreaNCP|NCP]] || [[BrainRegionNCP_NC_AL_SGCG|NCP.NC.AL.SGCG]] || Subgenual Cingulate Cortex || excitatory-glu || [http://openagrosrl.com/www/page/292/ Motor neurons control (CTX -> PRF, abstract)]
+
| [[BrainAreaNCP|NCP]] || [[BrainRegionNCP_NC_AL_SGCG|NCP.NC.AL.SGCG]] || Subgenual Cingulate Cortex || excitatory-glu || uncertain ||[http://openagrosrl.com/www/page/292/ Motor neurons control (CTX -> PRF, abstract)]
 
|}
 
|}
  
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{| class=wikitable width=80%
 
{| class=wikitable width=80%
−
| '''Target Area''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Reference'''
+
| '''Target Area''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Role''' || '''Reference'''
 
|-
 
|-
−
| [[BrainAreaFAM|FAM]] || [[BrainRegionFAM_FT_AM_CEL|FAM.FT.AM.CEL]] || Central Amygdaloid Nucleus, lateral subdivision || excitatory-glu || [http://neuropolitics.org/defaultmay10.asp Amygdalar disruption of prefrontal cortex (PB -> AM, abstract)]
+
| [[BrainAreaFAM|FAM]] || [[BrainRegionFAM_FT_AM_CEL|FAM.FT.AM.CEL]] || Central Amygdaloid Nucleus, lateral subdivision || excitatory-glu || uncertain || [http://neuropolitics.org/defaultmay10.asp Amygdalar disruption of prefrontal cortex (PB -> AM, abstract)]
 
|-
 
|-
−
| [[BrainAreaFEC|FEC]] || [[BrainRegionFEC_FT_ACC_SH|FEC.FT.ACC.SH]] || Nucleus Accumbens Shell || excitatory-glu || [http://www.nature.com/nrendo/journal/v6/n8/fig_tab/nrendo.2010.93_F1.html Bowels control brain: gut hormones and obesity (PBN -> NAc, abstract)]
+
| [[BrainAreaFEC|FEC]] || [[BrainRegionFEC_FT_ACC_SH|FEC.FT.ACC.SH]] || Nucleus Accumbens Shell || excitatory-glu || uncertain || [http://www.nature.com/nrendo/journal/v6/n8/fig_tab/nrendo.2010.93_F1.html Bowels control brain: gut hormones and obesity (PBN -> NAc, abstract)]
 
|-
 
|-
−
|  || [[BrainRegionFEC_FT_PU_LT|FEC.FT.PU.LT]] || Dorsal Putamen Lateral || excitatory-glu || [http://www.nature.com/nrendo/journal/v6/n8/fig_tab/nrendo.2010.93_F1.html Bowels control brain: gut hormones and obesity (PBN -> DS, abstract)]
+
|  || [[BrainRegionFEC_FT_PU_LT|FEC.FT.PU.LT]] || Dorsal Putamen Lateral || excitatory-glu || uncertain || [http://www.nature.com/nrendo/journal/v6/n8/fig_tab/nrendo.2010.93_F1.html Bowels control brain: gut hormones and obesity (PBN -> DS, abstract)]
 
|-
 
|-
−
|  || [[BrainRegionFEC_FT_PU_MED|FEC.FT.PU.MED]] || Dorsal Putamen Medial || excitatory-glu || [http://www.nature.com/nrendo/journal/v6/n8/fig_tab/nrendo.2010.93_F1.html Bowels control brain: gut hormones and obesity (PBN -> DS, abstract)]
+
|  || [[BrainRegionFEC_FT_PU_MED|FEC.FT.PU.MED]] || Dorsal Putamen Medial || excitatory-glu || uncertain || [http://www.nature.com/nrendo/journal/v6/n8/fig_tab/nrendo.2010.93_F1.html Bowels control brain: gut hormones and obesity (PBN -> DS, abstract)]
 
|-
 
|-
−
| [[BrainAreaLAC|LAC]] || [[BrainRegionLAC_FD_HT_DM|LAC.FD.HT.DM]] || Dorsomedial Hypothalamic Nucleus || excitatory-glu || [http://www.pnas.org/content/103/32/12150/F7.expansion.html Food-entrainable circadian oscillator (PBN -> DMH)]
+
| [[BrainAreaLAC|LAC]] || [[BrainRegionLAC_FD_HT_DM|LAC.FD.HT.DM]] || Dorsomedial Hypothalamic Nucleus || excitatory-glu || uncertain || [http://www.pnas.org/content/103/32/12150/F7.expansion.html Food-entrainable circadian oscillator (PBN -> DMH)]
 
|-
 
|-
−
|  || [[BrainRegionLAC_HL_VGN|LAC.HL.VGN]] || Vagus Nucleus || excitatory-glu || [http://www.intechopen.com/books/computational-intelligence-in-electromyography-analysis-a-perspective-on-current-applications-and-future-challenges/sphincter-emg-for-diagnosing-multiple-system-atrophy-and-related-disorders Physiology and pathophysiology of lower urinary tract (PBN -> DVM)]
+
|  || [[BrainRegionLAC_HL_VGN|LAC.HL.VGN]] || Vagus Nucleus || excitatory-glu || uncertain || [http://www.intechopen.com/books/computational-intelligence-in-electromyography-analysis-a-perspective-on-current-applications-and-future-challenges/sphincter-emg-for-diagnosing-multiple-system-atrophy-and-related-disorders Physiology and pathophysiology of lower urinary tract (PBN -> DVM)]
 
|-
 
|-
−
| [[BrainAreaNCP|NCP]] || [[BrainRegionNCP_FD_TH_VPI|NCP.FD.TH.VPI]] || Ventral Posteroinferior Nucleus || excitatory-glu || (unknown reference)
+
| [[BrainAreaNCP|NCP]] || [[BrainRegionNCP_FD_TH_VPI|NCP.FD.TH.VPI]] || Ventral Posteroinferior Nucleus || excitatory-glu || uncertain || (unknown reference)
 
|-
 
|-
−
|  || [[BrainRegionNCP_FD_TH_VPM|NCP.FD.TH.VPM]] || Ventral Posteromedial Nucleus || excitatory-glu || [http://www.sciencedirect.com/science/article/pii/S0149763401000215 Gustatory sensory system of rat and macaque (PB -> VPMpc)]
+
|  || [[BrainRegionNCP_FD_TH_VPM|NCP.FD.TH.VPM]] || Ventral Posteromedial Nucleus || excitatory-glu || uncertain || [http://www.sciencedirect.com/science/article/pii/S0149763401000215 Gustatory sensory system of rat and macaque (PB -> VPMpc)]
 
|-
 
|-
−
|  || [[BrainRegionNCP_NC_INS_PIC|NCP.NC.INS.PIC]] || Posterior Insular Cortex || excitatory-glu || [http://www.sciencedirect.com/science/article/pii/S0149763401000215 Gustatory sensory system of rat and macaque (PB -> Gud, abstract)]
+
|  || [[BrainRegionNCP_NC_INS_PIC|NCP.NC.INS.PIC]] || Posterior Insular Cortex || excitatory-glu || uncertain || [http://www.sciencedirect.com/science/article/pii/S0149763401000215 Gustatory sensory system of rat and macaque (PB -> Gud, abstract)]
 
|}
 
|}
  

Latest revision as of 18:30, 28 April 2019

Parabrachial Nucleus

@@Home -> BiologicalLifeResearch -> BrainAreaLPC -> BrainRegionLPC_HT_PRF_PB

This page covers biological details of component Parabrachial Nucleus. Region is part of aHuman target integrated biological model.

  • Top-down path to region: Hindbrain Metencephalon -> Pontine Reticular Formation (HT.RF) -> Pontine Reticular Formation, Lateral Column (HT.RF.LAT) -> Parabrachial Nucleus (LPC.HT.PRF.PB) (see Mind Maps)
  • Type: nucleus
  • Quality: L0
  • Brain area: Lower Brain - Peripheral Control Area (LPC)
  • Area circuit: Pain Sensations (SP)
  • Role: processor.affective
  • Function: Source of short-latency nociceptive input; sense of physiological condition of body well-being or interoception
  • Notes to function:
    • major relay site for visceral afferents ascending through ventrobasal thalamus and terminating in insular cortex

(generated)

Components

(generated)


Component items:

  • Subbrachial Nucleus
  • Lateral Parabrachial Nucleus
    • External Lateral Parabrachial Nucleus
  • Medial Parabrachial Nucleus

Connectivity

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LPC.HT.PRF.PB.dot.png

Inbound Region Connections:

Source Area Source Region Source Name Type Role Reference
FAM FAM.FT.IPAC.MED Medial Interstitial Anterior Commissural Nucleus excitatory-glu uncertain (unknown reference)
LPC LPC.HL.SOL Solitary Nucleus excitatory-glu uncertain Amygdalar disruption of prefrontal cortex (SOL -> PB)
NCP NCP.NC.AL.SGCG Subgenual Cingulate Cortex excitatory-glu uncertain Motor neurons control (CTX -> PRF, abstract)

Outbound Region Connections:

Target Area Target Region Target Name Type Role Reference
FAM FAM.FT.AM.CEL Central Amygdaloid Nucleus, lateral subdivision excitatory-glu uncertain Amygdalar disruption of prefrontal cortex (PB -> AM, abstract)
FEC FEC.FT.ACC.SH Nucleus Accumbens Shell excitatory-glu uncertain Bowels control brain: gut hormones and obesity (PBN -> NAc, abstract)
FEC.FT.PU.LT Dorsal Putamen Lateral excitatory-glu uncertain Bowels control brain: gut hormones and obesity (PBN -> DS, abstract)
FEC.FT.PU.MED Dorsal Putamen Medial excitatory-glu uncertain Bowels control brain: gut hormones and obesity (PBN -> DS, abstract)
LAC LAC.FD.HT.DM Dorsomedial Hypothalamic Nucleus excitatory-glu uncertain Food-entrainable circadian oscillator (PBN -> DMH)
LAC.HL.VGN Vagus Nucleus excitatory-glu uncertain Physiology and pathophysiology of lower urinary tract (PBN -> DVM)
NCP NCP.FD.TH.VPI Ventral Posteroinferior Nucleus excitatory-glu uncertain (unknown reference)
NCP.FD.TH.VPM Ventral Posteromedial Nucleus excitatory-glu uncertain Gustatory sensory system of rat and macaque (PB -> VPMpc)
NCP.NC.INS.PIC Posterior Insular Cortex excitatory-glu uncertain Gustatory sensory system of rat and macaque (PB -> Gud, abstract)

Thirdparty Circuits

(generated) 

EnP=Endopiriform Nucleus,FAM.FT.EPF
Gud=Insular Cortex,NC.INS
Gug=Insular Cortex,NC.INS
HF=Hippocampal Formation,FMM.FT.HF
IadIap=Insular Cortex,NC.INS
Iav=Insular Cortex,NC.INS
NST=Solitary Nucleus,LPC.HL.SOL
PB=Parabrachial Nucleus,LPC.HT.PRF.PB
PiR=Piriform Cortex,NSA.NC.PH.PIR
PrC=Perirhinal Cortex,FMM.NC.PH.PER
VPMpc=Ventral Posteromedial Nucleus,NCP.FD.TH.VPM


DMH=Dorsomedial Hypothalamic Nucleus,LAC.FD.HT.DM
LH=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN
NTS=Solitary Nucleus,LPC.HL.SOL
PBN=Parabrachial Nucleus,LPC.HT.PRF.PB
PVH=Paraventricular Nucleus,LAC.FD.HT.PV
SCN=Suprachiasmatic Nucleus,LAC.FD.HT.SCN


AMY=Amygdala,FAM.FT.AM
ARC=Arcuate Nucleus of Hypothalamus,LAC.FD.HT.AR
DS=Dorsal Striatum,FEC.FT.DST (see Basal Ganglia)
LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN
ME=Endocrine Glands,TARGET.TEA.ENDOCRINE
NAc=Accumbens Nucleus,FEC.FT.ACC (see Basal Ganglia)
NTS=Solitary Nucleus,LPC.HL.SOL
OFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
PBN=Parabrachial Nucleus,LPC.HT.PRF.PB
PVN=Paraventricular Nucleus,LAC.FD.HT.PV
VMN=Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM
VTA=Ventral Tegmental Area,LMC.MM.VTA


CN=Caudate Nucleus,FEC.FT.CN (see Basal Ganglia)
DVM=Vagus Nucleus,LAC.HL.VGN
IMG=Inferior Mesenteric Ganglion,LAC.PN.SYM.IMG
IML=Intermediolateral Nucleus,LAC.SC.IZ.IML
LC=Locus Coeruleus,LMC.HT.LC
MPFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
MPOA=Median Preoptic Nucleus,LAC.FD.HT.MPO
NBM=Basal Nucleus of Meynert,LMC.FT.NBM
ONF=Onuf's Nucleus,LPC.SC.VH.ONF
PBN=Parabrachial Nucleus,LPC.HT.PRF.PB
PEL=Pelvic Peripheral Ganglion,LAC.PN.PSYM.PPG
PU=Dorsal Putamen Lateral,FEC.FT.PU.LT
PVN=Paraventricular Nucleus,LAC.FD.HT.PV
SNC=Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT
SPS=Sacral Parasympathetic Nucleus,LAC.SC.IZ.SPS
VTA=Ventral Tegmental Area,LMC.MM.VTA
ZI=Subthalamic Nucleus Caudal,BGA.FD.STN.ZI


ACG=Anterior Cingulate Cortex,NC.AL.ACG (see Anterior Cingulate Area)
AM=Amygdala,FAM.FT.AM
HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation)
HT.L=Lateral Hypothalamic Area,LAC.FD.HT.LT (see Hypothalamus)
HT.PV=Paraventricular Nucleus,LAC.FD.HT.PV
INS=Insular Cortex,NC.INS
LC=Locus Coeruleus,LMC.HT.LC
MPFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex)
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
PB=Parabrachial Nucleus,LPC.HT.PRF.PB
PUT=Endocrine Glands,TARGET.TEA.ENDOCRINE
SOL=Solitary Nucleus,LPC.HL.SOL
TH=Thalamus,FD.TH


ACC=Anterior Cingulate Cortex,NC.AL.ACG (see Anterior Cingulate Area)
AMY=Amygdala,FAM.FT.AM
BG=Basal Ganglia,FEC.FT.BG
Cerebellum=Cerebellar Complex,LLC.HT.CRC
Insula=Insular Cortex,NC.INS
PAG=Periaqueductal Gray Matter,LMC.MM.PAG
PB=Parabrachial Nucleus,LPC.HT.PRF.PB
PFC=Prefrontal Cortex,NC.AL.PFC
S1=Primary Somatosensory Cortex,NCP.NC.PG.S1
S2=Secondary Somatosensory Cortex,NCP.NC.PG.S2
SC=Posterior/Dorsal Horn,BMA.SC.PH
Thalamus=Sensory Thalamus,FD.TH.SR


References

(generated)

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