BrainRegionLAC FD HT TBM

Tuberomammillary Nucleus

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This page covers biological details of component Tuberomammillary Nucleus. Region is part of aHuman target integrated biological model.

• Top-down path to region: Forebrain Diencephalon -> Hypothalamus (FD.HT) -> Lateral Hypothalamic Area (LAC.FD.HT.LT) -> Lateral Tuberal Nuclei (LAC.FD.HT.LTUB) -> Tuberomammillary Nucleus (LAC.FD.HT.TBM) (see Mind Maps)
• Type: nucleus
• Brain area: Lower Brain - Autonomous Control Area
• Role: processor.autonomic
• Function: sole source of histamine in the brain
• Notes to function:
  • regulate sleep, helps produce responses to sexual stimuli, and helps body respond to stressful situations

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Components

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Component items:

• Dorsal Tuberomammillary Nucleus
• Ventral Tuberomammillary Nucleus

Connectivity

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Inbound Region Connections:

• no connections

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Reference
FAM	FAM.FT.SEP.LT	Lateral Septal Nucleus	excitatory-glu	(unknown reference)
FMM	FMM.FD.MB.MMB	Medial Mammillary Nucleus	excitatory-glu	Mammillary bodies: two memory systems in one (TuberoMM -> MMB, abstract)
LAC	LAC.FD.HT.VLPO	Ventrolateral Preoptic Nucleus	excitatory-glu	Simplified NREM sleep-promoting pathway (TMN -> VLPO)
LMC	LMC.HT.LC	Locus Coeruleus	excitatory-glu	(unknown reference)
LPC	LPC.FT.MOB	Main Olfactory Bulb	excitatory-glu	(unknown reference)

Thirdparty Circuits

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• Mammillary bodies: two memory systems in one - see Reference (CT.MB-MEMORY)

ADTH=Anterodorsal Nucleus,FMM.FD.TH.AD
AMTH=Anteromedial Nucleus,NCP.FD.TH.AM
AVTH=Anteroventral Nucleus,FMM.FD.TH.AV
DTN=Laterodorsal Tegmental Nucleus,LMC.HT.TG.LDT
LMB=Lateral Mammillary Nucleus,FMM.FD.MB.LMB
MMB=Medial Mammillary Nucleus,FMM.FD.MB.MMB
MedialEC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex)
PAS=Parasubiculum,FMM.NC.PH.PAS
POS=Postsubiculum,FMM.NC.PH.POS
PRS=Presubiculum,FMM.NC.PH.PRS
SEP=Septal Nuclei,FAM.FT.SEP
SUB=Subiculum,FMM.FT.HF.SUB (see Hippocampal Formation)
SupraMM=Supramammillary Nucleus,LAC.FD.HT.SUM
TuberoMM=Lateral Tuberal Nuclei,LAC.FD.HT.LTUB (see Hypothalamus)
VTN=Ventral Tegmental Area,LMC.MM.VTA

• Simplified NREM sleep-promoting pathway - see Reference (CL.TBM-PO)

LC=Locus Coeruleus,LMC.HT.LC
LDTg=Laterodorsal Tegmental Nucleus,LMC.HT.TG.LDT
TMN=Tuberomammillary Nucleus,LAC.FD.HT.TBM
VLPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO

References

(generated)

• http://www.nature.com/nrn/journal/v5/n1/fig_tab/nrn1299_F2.html
• http://www.nature.com/neuro/journal/v5/n10/fig_tab/nn913_F1.html