BrainRegionLMC HT TG LDT

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Laterodorsal Tegmental Nucleus

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This page covers biological details of component Laterodorsal Tegmental Nucleus. Region is part of aHuman target integrated biological model.

  • Top-down path to region: Hindbrain Metencephalon -> Pontine Tegmental Nuclei (HT.TG) -> Laterodorsal Tegmental Nucleus (LMC.HT.TG.LDT) (see Mind Maps)
  • Type: nucleus
  • Quality: L0
  • Brain area: Lower Brain - Modulatory Contol Area (LMC)
  • Area circuit: Acetylcholine - PNS Actions and CNS plasticity, arousal and reward (ACH)
  • Role: processor.autonomic
  • Function: Modulating sustained attention or in mediating alerting responses
  • Notes to function:
    • sleep, waking, motor function, learning and reward




Component items:

  • Lateral Tegmental Nucleus
  • Dorsal Tegmental Nucleus (LMC.HT.TG.DTG): accurate landmark navigation
    • Dorsal Tegmental Nucleus Pars Dorsalis
    • Dorsal Tegmental Nucleus Pars Ventralis



Inbound Region Connections:

Source Area Source Region Source Name Type Role Reference
FAM FAM.FD.LHB.MED Lateral Habenula Medial Part excitatory-glu uncertain Regulation of the rapid eye movement (REM) sleep by habenular projection (LHbM -> DTG)
FEC FEC.HT.TG.IPD Interpeduncular Nucleus modulatory-ach uncertain Head Direction Cell Circuit (IPD -> DTN)
FEC.HT.TG.RMTG Rostromedial Tegmental Nucleus inhibitory-gaba uncertain (unknown reference)
FMM FMM.FD.MB.LMB Lateral Mammillary Nucleus excitatory-glu uncertain Head Direction Cell Circuit (LMB -> DTN)
LAC LAC.FD.HT.VLPO Ventrolateral Preoptic Nucleus excitatory-glu uncertain Simplified NREM sleep-promoting pathway (VLPO -> LDTg)
LRC LRC.HL.NPH Prepositus Nucleus excitatory-glu uncertain (unknown reference)
NSA NSA.FD.TH.SG Suprageniculate Nucleus of Thalamus excitatory-glu uncertain (unknown reference)

Outbound Region Connections:

Target Area Target Region Target Name Type Role Reference
FEC FEC.HT.TG.IPD Interpeduncular Nucleus modulatory-ach uncertain (unknown reference)
FMM FMM.FD.MB.LMB Lateral Mammillary Nucleus modulatory-ach uncertain Hippocampal Formation (DTN -> LMam)
LAC LAC.HL.SAL.ISL Inferior Salivatory Nucleus modulatory-ach uncertain (unknown reference)
LAC.HL.SAL.SSL Superior Salivatory Nucleus modulatory-ach uncertain (unknown reference)
LRC LRC.HL.NPH Prepositus Nucleus modulatory-ach uncertain Head Direction Cell Circuit (DTN -> NPRP)
NSA NSA.FD.TH.SG Suprageniculate Nucleus of Thalamus modulatory-ach uncertain Head Direction Cell Circuit (DTN -> SUPGEN)

Thirdparty Circuits


ATN=Anterior Nucleus of Thalamus,FD.TH.AN (see Cognitive Thalamus)
CA1=Ventrolateral Cornu Ammonis of Hippocampus,FMM.FT.HC.CA1 (see Hippocampal Formation)
CA3=Dorsomedial Cornu Ammonis of Hippocampus,FMM.FT.HC.CA3 (see Hippocampal Formation)
DG=Dentate Gyrus,FMM.FT.HC.DG
DTN=Laterodorsal Tegmental Nucleus,LMC.HT.TG.LDT
EC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex)
LDN=Lateral Dorsal Nucleus of Thalamus,FMM.FD.TH.LD
LMam=Lateral Mammillary Nucleus,FMM.FD.MB.LMB
Rsp=Retrosplenial Cortex,NCP.NC.MPL.RSC
Sub=Subiculum,FMM.FT.HF.SUB (see Hippocampal Formation)

AD=Anterodorsal Nucleus,FMM.FD.TH.AD
DTN=Laterodorsal Tegmental Nucleus,LMC.HT.TG.DTG
EC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex)
HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation)
IPD=Interpeduncular Nucleus,FEC.HT.TG.IPD
LD=Lateral Dorsal Nucleus of Thalamus,FMM.FD.TH.LD
LMB=Lateral Mammillary Nucleus,FMM.FD.MB.LMB
MVSN=Medial Vestibular Nucleus,LPC.HT.MVBN
NPRP=Prepositus Nucleus,LRC.HL.NPH
PC=Parietal Lobe,NC.LOBE.PAR
PRHC=Postrhinal Cortex,FMM.NC.PH.POR
RSP=Retrosplenial Cortex,NCP.NC.MPL.RSC
SUPGEN=Suprageniculate Nucleus of Thalamus,NSA.FD.TH.SG
VC=Occipital Lobe,NC.LOBE.OCC

DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB
DTG=Laterodorsal Tegmental Nucleus,LMC.HT.TG.DTG
EPN=Endopiriform Nucleus,FAM.FT.EPF
GPi=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia)
LHT=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN
LHbL=Lateral Habenula Lateral Part,FAM.FD.LHB.LT
LHbM=Lateral Habenula Medial Part,FAM.FD.LHB.MED
NI=Incertus Nucleus,FAM.HT.TG.NI
RMTg=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG
Raphe=Raphe Nuclei of Medulla,LMC.HL.RP (see Medullary Reticular Formation)
SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia)
VTA=Ventral Tegmental Area,LMC.MM.VTA
VTG=Ventral Tegmental Area,LMC.MM.VTG

ADTH=Anterodorsal Nucleus,FMM.FD.TH.AD
AMTH=Anteromedial Nucleus,NCP.FD.TH.AM
AVTH=Anteroventral Nucleus,FMM.FD.TH.AV
DTN=Laterodorsal Tegmental Nucleus,LMC.HT.TG.LDT
LMB=Lateral Mammillary Nucleus,FMM.FD.MB.LMB
MMB=Medial Mammillary Nucleus,FMM.FD.MB.MMB
MedialEC=Entorhinal Cortex,FMM.NC.PH.ET (see Rhinal Cortex)
SEP=Septal Nuclei,FAM.FT.SEP
SUB=Subiculum,FMM.FT.HF.SUB (see Hippocampal Formation)
SupraMM=Supramammillary Nucleus,LAC.FD.HT.SUM
TuberoMM=Lateral Tuberal Nuclei,LAC.FD.HT.LTUB (see Hypothalamus)
VTN=Ventral Tegmental Area,LMC.MM.VTA

LC=Locus Coeruleus,LMC.HT.LC
LDTg=Laterodorsal Tegmental Nucleus,LMC.HT.TG.LDT
TMN=Tuberomammillary Nucleus,LAC.FD.HT.TBM
VLPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO