BrainRegionFEC FD STN MED

Subthalamic Nucleus Medial

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This page covers biological details of component Subthalamic Nucleus Medial. Region is part of aHuman target integrated biological model.

• Top-down path to region: Forebrain Diencephalon -> Subthalamus Area (FEC.FD.STA) -> Subthalamic Nucleus (FEC.FD.STN) -> Subthalamic Nucleus Medial (FEC.FD.STN.MED) (see Mind Maps)
• Type: nucleus
• Quality: L0
• Brain area: Forebrain - Execution Control Area (FEC)
• Area circuit: Motor Extensor Loop (FECME)
• Role: basal.ganglia.subthalamus
• Function: Motor Extensor loop

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Components

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• no child items defined

Connectivity

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Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Role	Reference
LMC	LMC.HT.TG.PPN	Pedunculopontine Tegmental Nuclei	modulatory-ach	uncertain	Summary of the organization of the substantia nigra pars reticulata and pedunculopontine nucleus in lamprey (PPN -> STN, abstract)
NMA	NMA.NC.SMC.F6	Pre-Supplementary Motor Area	excitatory-glu	uncertain	Serotonin regulation of subthalamic neurons (CTX -> STN, abstract)
NPE	NPE.NC.PMC.AFEF	Anterior Frontal Eye Field	excitatory-glu	uncertain	Functional subdivisions of the subthalamic nucleus (FEF -> STN, abstract)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Role	Reference
FEC	FEC.FT.GPE.MED	Globus Pallidus External Medial	excitatory-glu	uncertain	Summary of the organization of the substantia nigra pars reticulata and pedunculopontine nucleus in lamprey (STN -> GPe, abstract)
	FEC.FT.GPI.MED	Globus Pallidus Internal Medial	excitatory-glu	uncertain	Basal Ganglia Activity (STN -> GPi, abstract)
	FEC.FT.SNR.DL	Substantia Nigra Pars Reticulata Dorsolateral	excitatory-glu	uncertain	Saccadic Vision (STN -> SNpr, abstract)

Thirdparty Circuits

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• Saccadic Vision - see Reference (CP.SACCADIC-VISION)

BG=Basal Ganglia,FEC.FT.BG
CN=Caudate Nucleus,FEC.FT.CN (see Basal Ganglia)
CR=Cerebellum,LLC.HT.CR (see Cerebellar Complex)
FrontalCortex=Anterior Lobe,NC.LOBE.ANT
GPe=Globus Pallidus External,FEC.FT.GPE (see Basal Ganglia)
LGN=Lateral Geniculate Nucleus,NSA.FD.LGN
LIP=Lateral Intraparietal Sulcus,NPE.NC.IPS.LIP
RF=Pontine Reticular Formation,HT.RF
Retina=Retinal Nucleus,LPC.FD.RT
SCi=Superior Colliculus,MM.SC (see Reflexes Nuclei of Midbrain Mesencephalon)
SCs=Superior Colliculus,MM.SC (see Reflexes Nuclei of Midbrain Mesencephalon)
SNpr=Substantia Nigra Pars Reticulata Dorsolateral,FEC.FT.SNR.DL
STN=Subthalamic Nucleus,FEC.FD.STN (see Subthalamus Area)
Thalamus=Thalamus,FD.TH
VisualCortex=Occipital Lobe,NC.LOBE.OCC

• Serotonin regulation of subthalamic neurons - see Reference (CM.SUBTHALAMUS)

CTX=Anterior Lobe,NC.LOBE.ANT
GPe=Globus Pallidus External,FEC.FT.GPE (see Basal Ganglia)
GPi=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia)
PPN=Pedunculopontine Tegmental Nuclei,LMC.HT.TG.PPN
SNr=Substantia Nigra Pars Reticulata,FEC.FT.SNR (see Basal Ganglia)
STN=Subthalamic Nucleus,FEC.FD.STN (see Subthalamus Area)

• Summary of the organization of the substantia nigra pars reticulata and pedunculopontine nucleus in lamprey - see Reference (CM.SN-PPN)

GPe=Globus Pallidus External,FEC.FT.GPE (see Basal Ganglia)
GPi=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia)
PPN=Pedunculopontine Tegmental Nuclei,LMC.HT.TG.PPN
SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia)
SNr=Substantia Nigra Pars Reticulata,FEC.FT.SNR (see Basal Ganglia)
STN=Subthalamic Nucleus,FEC.FD.STN (see Subthalamus Area)

• Basal Ganglia Activity - see Reference (CM.BASAL-GANGLIA-ACTIVITY)

GPi=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia)
GPo=Globus Pallidus External,FEC.FT.GPE (see Basal Ganglia)
M1=Motor Cortex,NMA.NC.MC
PMC=Premotor Cortex,NC.PMC
PU=Dorsal Putamen,FEC.FT.DPU (see Basal Ganglia)
S1=Primary Somatosensory Cortex,NCP.NC.PG.S1
SMC=Supplementary Motor Cortex,NMA.NC.SMC
SN=Substantia Nigra,FEC.FT.SN (see Basal Ganglia)
STN=Subthalamic Nucleus,FEC.FD.STN (see Subthalamus Area)
VLo=Ventral Lateral Nucleus,NMA.FD.TH.VL

References

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• http://www.nature.com/nrn/journal/v5/n3/box/nrn1345_BX1.html
• http://www.degruyter.com/view/j/revneuro.2014.25.issue-4/revneuro-2014-0004/revneuro-2014-0004.xml
• http://www.endurance-education.com/endurance-education-com/does-only-our-brainstem-select-our-motor-programs
• http://thebrain.mcgill.ca/flash/a/a_06/a_06_cr/a_06_cr_mou/a_06_cr_mou.html