BrainRegionNMA NC SMC F6

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Pre-Supplementary Motor Area

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This page covers biological details of component Pre-Supplementary Motor Area. Region is part of aHuman target integrated biological model.

  • Top-down path to region: Cerebral Cortex -> Anterior Lobe (NC.LOBE.ANT) -> Supplementary Motor Cortex (NMA.NC.SMC) -> Pre-Supplementary Motor Area (NMA.NC.SMC.F6) (see Mind Maps)
  • Type: cortex
  • Brain area: Neocortical Brain - Motor Aggregation Area
  • Brodmann ID: 06
  • Role: cortex.generic
  • Function: High level motor functions; Numerical and verbal mental-operation tasks
  • Notes to function: from TH/VLpc, MD from caudate, CR; F5/24c/46; no connections with F1




  • no child items defined



Inbound Region Connections:

Source Area Source Region Source Name Type Reference
NDM NDM.NC.AL.DLPFCR Rostral Mid-Dorsolateral Prefrontal Cortex feedforward-glu Primate Control of Grasping (46 -> F6, abstract)
NMA NMA.FD.TH.VA Ventral Anterior Nucleus excitatory-glu Primate Control of Grasping (BTH -> F6)
NMA.FD.TH.VL Ventral Lateral Nucleus excitatory-glu Basal Ganglia Activity (VLo -> SMC, abstract)

Outbound Region Connections:

Target Area Target Region Target Name Type Reference
FEC FEC.FD.STN.MED Subthalamic Nucleus Medial excitatory-glu Serotonin regulation of subthalamic neurons (CTX -> STN, abstract)
FEC.FT.PU.MED Dorsal Putamen Medial excitatory-glu Primate Control of Grasping (F6 -> BG, abstract)
NMA NMA.NC.PMC.F4 Ventral Caudal Premotor Cortex feedforward-glu Primate Control of Grasping (F6 -> F4)
NMA.NC.PMC.F5 Ventral Rostral Premotor Cortex feedforward-glu Primate Control of Grasping (F6 -> F5)

Thirdparty Circuits


CTX=Anterior Lobe,NC.LOBE.ANT
GPe=Globus Pallidus External,FEC.FT.GPE (see Basal Ganglia)
GPi=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia)
PPN=Pedunculopontine Tegmental Nuclei,LMC.HT.TG.PPN
SNr=Substantia Nigra Pars Reticulata,FEC.FT.SNR (see Basal Ganglia)
STN=Subthalamic Nucleus,FEC.FD.STN (see Subthalamus Area)

46=Mid-Dorsolateral Prefrontal Cortex,NDM.NC.AL.DLPFC (see Lateral Prefrontal Cortex)
AIP=Anterior Intraparietal Sulcus,NSA.NC.IPS.AIP
BG=Basal Ganglia,FEC.FT.BG
BTH=Ventral Anterior Nucleus,NMA.FD.TH.VA
F1=Motor Cortex,NMA.NC.MC
F2=Dorsal Caudal Premotor Cortex,NMA.NC.PMC.F2
F4=Ventral Caudal Premotor Cortex,NMA.NC.PMC.F4
F5=Ventral Rostral Premotor Cortex,NMA.NC.PMC.F5
F6=Pre-Supplementary Motor Area,NMA.NC.SMC.F6
IT=Inferotemporal Area,NSA.NC.IT
PIP=Posterior Eye Field,NPE.NC.IPS.PEF (see Intraparietal Sulcus)
S1=Primary Somatosensory Cortex,NCP.NC.PG.S1
S2=Primary Somatosensory Cortex,NCP.NC.PG.S1
VC=Occipital Lobe,NC.LOBE.OCC
VIP=Ventral Intraparietal Sulcus,NSA.NC.IPS.VIP