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Anterior Frontal Eye Field

@@Home -> BiologicalLifeResearch -> BrainAreaNPE -> BrainRegionNPE_NC_PMC_AFEF

This page covers biological details of component Anterior Frontal Eye Field. Region is part of aHuman target integrated biological model.

  • Top-down path to region: Cerebral Cortex -> Anterior Lobe (NC.LOBE.ANT) -> Premotor Cortex (NC.PMC) -> Frontal Eye Field (NMA.NC.PMC.FEF) -> Anterior Frontal Eye Field (NPE.NC.PMC.AFEF) (see Mind Maps)
  • Type: cortex
  • Brain area: Neocortical Brain - Unimodal Execution Area
  • Brodmann ID: 08
  • Role: cortex.generic
  • Function: Head and eye movements toward auditory stimuli
  • Notes to function: longer saccades, dorsomedial - 8A (8Ac, 8Am), but not 8Ar; 8Ac - saccades




  • no child items defined



Inbound Region Connections:

Source Area Source Region Source Name Type Reference
NDM NDM.NC.AL.DLPFCL Lateral Mid-Dorsolateral Prefrontal Cortex feedforward-glu Prefrontal Cortex (PFC) in motor behavior (LPFC -> PMC, abstract)
NMA NMA.FD.TH.MDL Lateral Mediodorsal Nucleus of Thalamus excitatory-glu Oculomotor decision-making (Thalamus -> FEF, abstract)
NPE NPE.NC.BRA.PO Broca's Area Pars Opercularis feedforward-glu Cortical Auditory System (IFC44 -> PMC8, abstract)
NPE.NC.PMC.CFEF Caudal Frontal Eye Field feedforward-glu (unknown reference)
NPE.NC.SMC.SEF Supplementary Eye Field feedforward-glu Summary of eye movement control (SEF -> FEF, abstract)

Outbound Region Connections:

Target Area Target Region Target Name Type Reference
FEC FEC.FD.STN.MED Subthalamic Nucleus Medial excitatory-glu Functional subdivisions of the subthalamic nucleus (FEF -> STN, abstract)
FEC.FT.CN.BD Caudate Nucleus Body excitatory-glu Global visual system (FrontalCortex -> BGA, abstract)
LRC LRC.HL.PRF.GCR Gigantocellular Reticular Nucleus excitatory-glu Motor neurons control (CTX -> MRF, abstract)
LRC.HT.PRF.RPO Oral Pontine Reticular Nucleus excitatory-glu Motor neurons control (CTX -> PRF, abstract)
LRC.MM.CJ Cajal Nucleus excitatory-glu Summary of eye movement control (FEF -> riMLF, abstract)
LRC.MM.DSCH Darkschewitsch Nucleus excitatory-glu (unknown reference)
LRC.MM.SC.INT Intermediate Superior Colliculus excitatory-glu Summary of eye movement control (FEF -> SC, abstract)
NMA NMA.NC.PMC.F5 Ventral Rostral Premotor Cortex feedforward-glu Cortical Auditory System (PMC8 -> PMC6, abstract)
NMA.NC.PMC.F7 Dorsal Rostral Premotor Cortex feedforward-glu (unknown reference)

Thirdparty Circuits


ATH=Anterior Nucleus of Thalamus,FD.TH.AN (see Cognitive Thalamus)
BGA=Basal Ganglia,FEC.FT.BG
FrontalCortex=Anterior Lobe,NC.LOBE.ANT
LGN=Lateral Geniculate Nucleus,NSA.FD.LGN
OPN=Oculomotor Nucleus,LPC.MM.OCN
ParietalCortex=Parietal Lobe,NC.LOBE.PAR
Pulvinar=Pulvinar,FD.PV (see Sensory Thalamus)
RF=Pontine Reticular Formation,HT.RF
Retina=Retinal Nucleus,LPC.FD.RT
SCi=Superior Colliculus,MM.SC (see Reflexes Nuclei of Midbrain Mesencephalon)
SCs=Superior Colliculus,MM.SC (see Reflexes Nuclei of Midbrain Mesencephalon)
SNc=Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT
SNr=Substantia Nigra Pars Reticulata Dorsolateral,FEC.FT.SNR.DL
SpinalCord=Lamina IX,SC.VH.L9 (see Anterior/Ventral Horn)
Striatum=Striatum,FEC.FT.ST (see Basal Ganglia)
VisualCortex=Occipital Lobe,NC.LOBE.OCC

DLPFC=Mid-Dorsolateral Prefrontal Cortex,NDM.NC.AL.DLPFC (see Lateral Prefrontal Cortex)
FEF=Frontal Eye Field,NMA.NC.PMC.FEF (see Premotor Cortex)
PEF=Posterior Eye Field,NPE.NC.IPS.PEF (see Intraparietal Sulcus)
PPRF=Paramedian Pontine Reticular Formation,HT.PRF.PPRF (see Pontine Reticular Formation)
SC=Superior Colliculus,MM.SC (see Reflexes Nuclei of Midbrain Mesencephalon)
SEF=Supplementary Eye Field,NPE.NC.SMC.SEF
riMLF=Cajal Nucleus,LRC.MM.CJ

AC22=Wernicke's area A4,NSA.NC.STG.A4
Belt42=Auditory Association Area,NSA.NC.TTG.A2
Core41=Primary Auditory Cortex,NSA.NC.TTG.A1
IFC44=Broca's Area,NPE.NC.PFC.BRA (see Lateral Prefrontal Cortex)
IFC45=Broca's Area,NPE.NC.PFC.BRA (see Lateral Prefrontal Cortex)
IPL40=Supramarginal Gyrus,NC.IPL.SMG (see Inferior Parietal Lobule)
PMC6=Ventral Premotor Cortex,MCA.NC.VPMC (see Premotor Cortex)
PMC8=Anterior Frontal Eye Field,NPE.NC.PMC.AFEF
STS22=Wernicke's area A3,NSA.NC.STG.A3

ACG=Anterior Cingulate Cortex,NC.AL.ACG (see Anterior Cingulate Area)
FEF=Frontal Eye Field,NMA.NC.PMC.FEF (see Premotor Cortex)
GPe=Globus Pallidus External,FEC.FT.GPE (see Basal Ganglia)
GPi=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia)
MC=Motor Cortex,NMA.NC.MC
SNr=Substantia Nigra Pars Reticulata,FEC.FT.SNR (see Basal Ganglia)
STN=Subthalamic Nucleus,FEC.FD.STN (see Subthalamus Area)
VP=Ventral Pallidum,FEC.FT.VP (see Basal Ganglia)

CR=Cerebellum,LLC.HT.CR (see Cerebellar Complex)
CTX=Anterior Lobe,NC.LOBE.ANT
EAMN=Anterior/Ventral Horn,SC.VH
EGMN=Anterior/Ventral Horn,SC.VH
FAMN=Anterior/Ventral Horn,SC.VH
FG=Fastigual Nucleus,LRC.HT.CR.FG
IP=Interposed Nucleus,LLC.HT.CR.IP (see Cerebellar Complex)
LT=Dentate Nucleus,LLC.HT.CR.DN
MRF=Medullary Reticular Formation,HL.RF
PRF=Pontine Reticular Formation,HT.RF
RD=Red Nucleus,LLC.MM.RD
VB=Vestibular Nuclei,LPC.HT.VBN

A1=Primary Auditory Cortex,NSA.NC.TTG.A1
AA=Wernicke's area A3,NSA.NC.STG.A3
M1=Motor Cortex,NMA.NC.MC
MA=Premotor Cortex,NC.PMC
PFC=Prefrontal Cortex,NC.AL.PFC
PTHA=Inferior Parietal Lobule,NC.IPL
S1=Primary Somatosensory Cortex,NCP.NC.PG.S1
SA=Somatosensory Association Cortex,NCP.NC.SPL.SA
V1=Primary Visual Cortex,NSA.NC.OCC.V1
VA=Secondary Visual Cortex,NSA.NC.OCC.V2 (see Occipital Lobe)