BrainRegionLRC HL PRF GCR

Gigantocellular Reticular Nucleus

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This page covers biological details of component Gigantocellular Reticular Nucleus. Region is part of aHuman target integrated biological model.

• Top-down path to region: Hindbrain Myelencephalon -> Medullary Reticular Formation (HL.RF) -> Medullary Reticular Formation, Medial Column (HL.RF.MED) -> Gigantocellular Reticular Nucleus (LRC.HL.PRF.GCR) (see Mind Maps)
• Type: nucleus
• Quality: L0
• Brain area: Lower Brain - Motor Reflex Area (LRC)
• Area circuit: Postural Control Reflexes (LRP)
• Role: subcortical.motor.flexor
• Function: Vasodepressor center
• Notes to function:
  • Projects to hypoglossal nucleus, abducens
  • medullary (lateral) reticulospinal tract
  • excite trunk flexors, inhibit extensors
  • stimulation induces inspiration

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Components

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• no child items defined

Connectivity

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Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Role	Reference
LPC	LPC.HL.TGS.STR	Spinal Trigeminal Nucleus	excitatory-glu	uncertain	(unknown reference)
LRC	LRC.MM.CNF	Cuneiform Nucleus	excitatory-glu	uncertain	(unknown reference)
NMA	NMA.NC.SMC.F3	Supplementary Motor Area	excitatory-glu	uncertain	Motor neurons control (CTX -> MRF, abstract)
NPE	NPE.NC.PMC.AFEF	Anterior Frontal Eye Field	excitatory-glu	uncertain	Motor neurons control (CTX -> MRF, abstract)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Role	Reference
LPC	LPC.SC.VH.PL	Posterolateral Nucleus	excitatory-glu	uncertain	Motor neurons control (MRF -> EGMN, abstract)
	LPC.SC.VH.PM	Posteromedial Nucleus	excitatory-glu	uncertain	Motor neurons control (MRF -> EGMN, abstract)
LRC	LRC.HL.RF.MED	Central Medullary Reticular Nucleus	excitatory-glu	uncertain	(unknown reference)
	LRC.MM.SCNF	Subcuneiform Nucleus	excitatory-glu	uncertain	(unknown reference)

Thirdparty Circuits

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• Motor neurons control - see Reference (CM.CR-MN)

CR=Cerebellum,LLC.HT.CR (see Cerebellar Complex)
CTX=Anterior Lobe,NC.LOBE.ANT
EAMN=Anterior/Ventral Horn,SC.VH
EGMN=Anterior/Ventral Horn,SC.VH
FAMN=Anterior/Ventral Horn,SC.VH
FG=Fastigual Nucleus,LRC.HT.CR.FG
IP=Interposed Nucleus,LLC.HT.CR.IP (see Cerebellar Complex)
LT=Dentate Nucleus,LLC.HT.CR.DN
MRF=Medullary Reticular Formation,HL.RF
PRF=Pontine Reticular Formation,HT.RF
RD=Red Nucleus,LLC.MM.RD
VB=Vestibular Nuclei,LPC.HT.VBN

References

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• http://openagrosrl.com/www/page/292/