Ventral Tegmental Area

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This page covers biological details of component Ventral Tegmental Area. Region is part of aHuman target integrated biological model.

Top-down path to region: Midbrain Mesencephalon -> Ventral Tegmental Area (LMC.MM.VTA) (see Mind Maps)
Type: nucleus
Brain area: Lower Brain - Modulatory Contol Area
Role: relay
Function: Respond to novel stimuli, unexpected rewards, and reward predictive sensory cues

(generated)

Components

(generated)

Component items:

Ventral Tegmental Nucleus (LMC.MM.VTG): moderates hippocampal-driven rhythmic firing frequency in medial mammillary
Parabrachial Pigmented Area
Paranigral Nucleus
Parafasciculus Retroflexus Area

Connectivity

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LMC.MM.VTA.dot.png

Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Reference
FAM	FAM.FD.LHB.MED	Lateral Habenula Medial Part	excitatory-glu	Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> VTA)
	FAM.FT.BNST	Bed Nucleus of Stria Terminalis	excitatory-glu	(unknown reference)
FEC	FEC.FT.ACC.CORE	Nucleus Accumbens Core	inhibitory-gaba	Reward circuit of human brain (NACC -> VTA, abstract)
	FEC.FT.VP.VM	Ventral Pallidum Ventromedial	inhibitory-gaba	Craving (VPAL -> VTA, abstract)
	FEC.HT.PPN.IPD	Interpeduncular Nucleus	modulatory-ach	Both LHb and MHb control the dopaminergic and serotonergic systems (IPN -> VTA)
	FEC.HT.PPN.RMTG	Rostromedial Tegmental Nucleus	inhibitory-gaba	Amygdala and its network (RMTG -> VTA)
LPC	LPC.HL.SOL	Solitary Nucleus	excitatory-glu	Bowels control brain: gut hormones and obesity (NTS -> VTA)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Reference
FAM	FAM.FT.AM.CEC	Central Amygdaloid Nucleus, capsular subdivision	modulatory-da	Reward circuit of human brain (VTA -> AM, abstract)
FEC	FEC.FT.ACC.SH	Nucleus Accumbens Shell	modulatory-da	Craving (VTA -> NACC, abstract)
	FEC.FT.PU.LT	Dorsal Putamen Lateral	modulatory-da	Bowels control brain: gut hormones and obesity (VTA -> DS, abstract)
	FEC.FT.PU.MED	Dorsal Putamen Medial	modulatory-da	Bowels control brain: gut hormones and obesity (VTA -> DS, abstract)
FMM	FMM.FD.MB.MMB	Medial Mammillary Nucleus	modulatory-da	Mammillary bodies: two memory systems in one (VTN -> MMB)
	FMM.FT.HC.CA1D	Distal CA1 of Hippocampus	modulatory-da	Reward circuit of human brain (VTA -> HC, abstract)
	FMM.NC.PH.LEC	Lateral Entorhinal Cortex	modulatory-da	Combining Novelty, Motivational Salience, and Reward to Control Attention and Learning (VTA -> EC, abstract)
LAC	LAC.FD.HT.PO	Preoptic Nucleus	modulatory-da	Physiology and pathophysiology of lower urinary tract (VTA -> MPOA)
	LAC.FD.HT.PRM	Premammillary Nucleus	modulatory-da	(unknown reference)
	LAC.FD.HT.PV	Paraventricular Nucleus	modulatory-da	Physiology and pathophysiology of lower urinary tract (VTA -> PVN)
NDM	NDM.NC.AL.DACG	Dorsal Anterior Cingulate Area	modulatory-da	(unknown reference)
	NDM.NC.AL.FPC	Lateral Frontopolar Cortex	modulatory-da	Amygdala and its network (VTA -> MPFC, abstract)