BrainRegionLLC HT PRF RTMG

Pontine Reticulotegmental Nucleus

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This page covers biological details of component Pontine Reticulotegmental Nucleus. Region is part of aHuman target integrated biological model.

• Top-down path to region: Hindbrain Metencephalon -> Pontine Reticular Formation (HT.RF) -> Pontine Reticular Formation, Lateral Column (HT.RF.LAT) -> Pontine Reticulotegmental Nucleus (LLC.HT.PRF.RTMG) (see Mind Maps)
• Type: nucleus
• Quality: L0
• Brain area: Lower Brain - Locomotion Control Area (LLC)
• Area circuit: Cerebrocerebellar Locomotion (LLC)
• Role: processor.automatic
• Function: Mediate saccadic eye movements
• Comments: Nucleus of Bechterew, tegmentopontine reticular nucleus, projections from superior colliculus to vermis of CR
• Notes to function:
  • Inactivation leads to deficit of expression, but not learning

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Components

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• no child items defined

Connectivity

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Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Role	Reference
FMM	FMM.FD.MB.LMB	Lateral Mammillary Nucleus	excitatory-glu	uncertain	Mammillary Body (LMB -> RTG)
	FMM.FD.MB.MMB	Medial Mammillary Nucleus	excitatory-glu	uncertain	Mammillary Body (MMB -> RTG)
LPC	LPC.HL.TGS.STR	Spinal Trigeminal Nucleus	excitatory-glu	uncertain	Eye blink reflex and pupillary light reflex (SpinalTrigeminal -> RF, abstract)
LRC	LRC.MM.SC.DEEP	Deep Superior Colliculus	excitatory-glu	uncertain	Geniculate and Extyrageniculate Paths (SC -> RF, abstract)
	LRC.MM.SC.INT	Intermediate Superior Colliculus	excitatory-glu	uncertain	Geniculate and Extyrageniculate Paths (SC -> RF, abstract)
NDM	NDM.NC.AL.VACG	Ventral Anterior Cingulate Area	excitatory-glu	uncertain	Motor neurons control (CTX -> PRF, abstract)
NMA	NMA.NC.MC	Motor Cortex	excitatory-glu	uncertain	Motor neurons control (CTX -> PRF, abstract)
	NMA.NC.SMC.F3	Supplementary Motor Area	excitatory-glu	uncertain	Motor neurons control (CTX -> PRF, abstract)
NPE	NPE.NC.BRA.PO	Broca's Area Pars Opercularis	excitatory-glu	uncertain	Motor neurons control (CTX -> PRF, abstract)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Role	Reference
LRC	LRC.HT.CR.FN	Cerebellar Flocconodular Lobe	inhibitory-gaba	uncertain	(unknown reference)
	LRC.HT.CR.VM	Cerebellar Vermis	inhibitory-gaba	uncertain	(unknown reference)

Thirdparty Circuits

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• Mammillary Body (unknown reference) (CT.LMB-MMB)

LMB=Lateral Mammillary Nucleus,FMM.FD.MB.LMB
MMB=Medial Mammillary Nucleus,FMM.FD.MB.MMB
RTG=Pontine Reticulotegmental Nucleus,LLC.HT.PRF.RTMG

• Horizontal saccades and smooth pursuit movements - see Reference (CP.VISION-SACCADES)

Bechterew=Pontine Reticulotegmental Nucleus,LLC.HT.PRF.RTMG
CR=Cerebellum,LLC.HT.CR (see Cerebellar Complex)
FEFSEF=Anterior Lobe,NC.LOBE.ANT
LGB=Lateral Geniculate Nucleus,NSA.FD.LGN
PPRF=Paramedian Pontine Reticular Formation,HT.PRF.PPRF (see Pontine Reticular Formation)
PrimaryVisual=Primary Visual Cortex,NSA.NC.OCC.V1
RIP=Raphe Interpositus Nucleus,LRC.MM.RP.RIP
SC=Superior Colliculus,MM.SC (see Reflexes Nuclei of Midbrain Mesencephalon)
Striatum=Striatum,FEC.FT.ST (see Basal Ganglia)
Vestibular=Superior Vestibular Nucleus,LPC.HT.SVBN
VisualAssociation=Caudal Precuneus,NPE.NC.SPL.PG

References

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• http://www.sciencedirect.com/science/article/pii/S0006899301025987