Revision as of 10:00, 2 September 2015

Lateral Habenula Medial Part

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This page covers biological details of component Lateral Habenula Medial Part. Region is part of aHuman target integrated biological model.

Top-down path to region: Forebrain Diencephalon -> Habenula (FAM.FD.HB) -> Lateral Habenula (FAM.FD.LHB) -> Lateral Habenula Medial Part (FAM.FD.LHB.MED) (see Mind Maps)
Type: nucleus
Brain area: Forebrain - Affective Motivations Area
Role: relay
Function: Encoding negative feedback, direct, Septal

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Components

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FAM.FD.LHB.MED.dot.png

Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Reference
FAM	FAM.FD.MHB	Medial Habenula	excitatory-glu	Connectivity map of the habenula (M -> L, abstract)
	FAM.FT.SEP.DBB	Diagonal Band of Broca	inhibitory-gaba	Both LHb and MHb control the dopaminergic and serotonergic systems (DBB -> LHbM)
	FAM.FT.SEP.LT	Lateral Septal Nucleus	inhibitory-gaba	Both LHb and MHb control the dopaminergic and serotonergic systems (LS -> LHbM)
FEC	FEC.FT.VP.VM	Ventral Pallidum Ventromedial	inhibitory-gaba	Both LHb and MHb control the dopaminergic and serotonergic systems (VP -> LHbM, abstract)
LAC	LAC.FD.HT.LTN	Lateral Hypothalamic Nucleus	excitatory-glu	Both LHb and MHb control the dopaminergic and serotonergic systems (LHA -> LHbM)
	LAC.FD.HT.PO	Preoptic Nucleus	excitatory-glu	Both LHb and MHb control the dopaminergic and serotonergic systems (LPO -> LHbM)
LMC	LMC.HT.LC	Locus Coeruleus	modulatory-ne	Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> LHB, abstract)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Reference
FAM	FAM.HT.TG.NI	Incertus Nucleus	excitatory-glu	Regulation of the rapid eye movement (REM) sleep by habenular projection (LHbM -> NI)
FEC	FEC.FT.SNC.LT	Substantia Nigra Pars Compacta Lateral	excitatory-glu	Habenula Connections (LHb -> SNc, abstract)
	FEC.HT.PPN.RMTG	Rostromedial Tegmental Nucleus	excitatory-glu	Regulation of the rapid eye movement (REM) sleep by habenular projection (LHbM -> RMTg)
LMC	LMC.HL.RP.MG	Raphe Magnus Nucleus	excitatory-glu	Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> MRN, abstract)
	LMC.HT.TG.DTG	Dorsal Tegmental Nucleus	excitatory-glu	Regulation of the rapid eye movement (REM) sleep by habenular projection (LHbM -> DTG)
	LMC.MM.RF.SUC	Superior Central Raphe Nucleus	excitatory-glu	Habenula Connections (LHb -> MR, abstract)
	LMC.MM.RP.DRN	Dorsal Raphe Nucleus	excitatory-glu	Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> DRN)
	LMC.MM.VTA	Ventral Tegmental Area	excitatory-glu	Both LHb and MHb control the dopaminergic and serotonergic systems (LHbM -> VTA)

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 |-
 |  || [[BrainRegionLAC_FD_HT_PO|LAC.FD.HT.PO]] || Preoptic Nucleus || excitatory-glu || [http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (LPO -> LHbM)]
+|-
+| [[BrainAreaLMC|LMC]] || [[BrainRegionLMC_HT_LC|LMC.HT.LC]] || Locus Coeruleus || modulatory-ne || [http://www.nature.com/nrn/journal/v11/n6/fig_tab/nrn2849_F7.html Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> LHB, abstract)]
 |}