Difference between revisions of "BrainRegionLMC HT LC"
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* '''Top-down path to region''': Hindbrain Metencephalon -> [[BrainRegionLMC_HT_LC|Locus Coeruleus]] (LMC.HT.LC) (see [[OverallMindMaps|Mind Maps]]) | * '''Top-down path to region''': Hindbrain Metencephalon -> [[BrainRegionLMC_HT_LC|Locus Coeruleus]] (LMC.HT.LC) (see [[OverallMindMaps|Mind Maps]]) | ||
* '''Type''': nucleus | * '''Type''': nucleus | ||
| − | * '''Brain area''': [[BrainAreaLMC|Lower Brain - Modulatory Contol Area]] | + | * '''Quality''': L0 |
| + | * '''Brain area''': [[BrainAreaLMC|Lower Brain - Modulatory Contol Area]] (LMC) | ||
| + | * '''Area circuit''': Norepinephrine - Vigilant Concentration, Stress Hormone, Fight-or-Flight Response (NE) | ||
* '''Role''': processor.autonomic | * '''Role''': processor.autonomic | ||
| − | * '''Function''': Regulate the intensity of responses to salient stimuli | + | * '''Function''': Regulate the intensity of responses to salient stimuli, arousal and autonomic activity |
| − | * '''Notes to function''': NE Source, enhance signal-to-noise ratio, suppressing irrelevant stimuli (lateral inhibition) | + | * '''Notes to function''': |
| + | ** NE Source, enhance signal-to-noise ratio, suppressing irrelevant stimuli (lateral inhibition) | ||
| + | ** inhibitory nucleus | ||
| + | ** wakefulness-promoting nucleus, enhancement of alertness, increase in sympathetic activity and a decrease in parasympathetic activity, to all neocortex, medial septal area, medial preoptic area and substantia innominata, central and basal amygdala, dorsal thalamus | ||
(generated) | (generated) | ||
= Components = | = Components = | ||
| Line 28: | Line 33: | ||
{| class=wikitable width=80% | {| class=wikitable width=80% | ||
| − | | '''Source Area''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Reference''' | + | | '''Source Area''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Role''' || '''Reference''' |
|- | |- | ||
| − | | [[BrainAreaFAM|FAM]] || [[BrainRegionFAM_FT_AM_CEM|FAM.FT.AM.CEM]] || Medial Central Amygdaloid Nucleus || excitatory-glu || [http://neuropolitics.org/defaultmay10.asp Amygdalar disruption of prefrontal cortex (AM -> LC, abstract)] | + | | [[BrainAreaFAM|FAM]] || [[BrainRegionFAM_FT_AM_CEM|FAM.FT.AM.CEM]] || Medial Central Amygdaloid Nucleus || excitatory-glu || uncertain ||[http://neuropolitics.org/defaultmay10.asp Amygdalar disruption of prefrontal cortex (AM -> LC, abstract)] |
|- | |- | ||
| − | | || [[BrainRegionFAM_FT_BNST|FAM.FT.BNST]] || Bed Nucleus of Stria Terminalis || excitatory-glu || (unknown reference) | + | | || [[BrainRegionFAM_FT_BNST|FAM.FT.BNST]] || Bed Nucleus of Stria Terminalis || excitatory-glu || uncertain ||(unknown reference) |
|- | |- | ||
| − | | [[BrainAreaLAC|LAC]] || [[BrainRegionLAC_FD_HT_DM|LAC.FD.HT.DM]] || Dorsomedial Hypothalamic Nucleus || excitatory-glu || [http://journal.frontiersin.org/article/10.3389/fnint.2012.00094/full Effect of light on pupil diameter (DMH -> LC)] | + | | [[BrainAreaLAC|LAC]] || [[BrainRegionLAC_FD_HT_DM|LAC.FD.HT.DM]] || Dorsomedial Hypothalamic Nucleus || excitatory-glu || uncertain ||[http://journal.frontiersin.org/article/10.3389/fnint.2012.00094/full Effect of light on pupil diameter (DMH -> LC)] |
|- | |- | ||
| − | | || [[BrainRegionLAC_FD_HT_TBM|LAC.FD.HT.TBM]] || Tuberomammillary Nucleus || excitatory-glu || (unknown reference) | + | | || [[BrainRegionLAC_FD_HT_TBM|LAC.FD.HT.TBM]] || Tuberomammillary Nucleus || excitatory-glu || uncertain ||(unknown reference) |
|- | |- | ||
| − | | [[BrainAreaLRC|LRC]] || [[BrainRegionLRC_HL_RF_MED|LRC.HL.RF.MED]] || Central Medullary Reticular Nucleus || excitatory-glu || (unknown reference) | + | | [[BrainAreaLRC|LRC]] || [[BrainRegionLRC_HL_RF_MED|LRC.HL.RF.MED]] || Central Medullary Reticular Nucleus || excitatory-glu || uncertain ||(unknown reference) |
|- | |- | ||
| − | | [[BrainAreaNDM|NDM]] || [[BrainRegionNDM_NC_AL_VACG|NDM.NC.AL.VACG]] || Ventral Anterior Cingulate Area || excitatory-glu || (unknown reference) | + | | [[BrainAreaNDM|NDM]] || [[BrainRegionNDM_NC_AL_VACG|NDM.NC.AL.VACG]] || Ventral Anterior Cingulate Area || excitatory-glu || uncertain ||(unknown reference) |
|} | |} | ||
| Line 46: | Line 51: | ||
{| class=wikitable width=80% | {| class=wikitable width=80% | ||
| − | | '''Target Area''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Reference''' | + | | '''Target Area''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Role''' || '''Reference''' |
|- | |- | ||
| − | | [[BrainAreaFAM|FAM]] || [[BrainRegionFAM_FD_LHB_LT|FAM.FD.LHB.LT]] || Lateral Habenula Lateral Part || modulatory-ne || [http://www.nature.com/nrn/journal/v11/n6/fig_tab/nrn2849_F7.html Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> LHB, abstract)] | + | | [[BrainAreaFAM|FAM]] || [[BrainRegionFAM_FD_LHB_LT|FAM.FD.LHB.LT]] || Lateral Habenula Lateral Part || modulatory-ne || uncertain || [http://www.nature.com/nrn/journal/v11/n6/fig_tab/nrn2849_F7.html Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> LHB, abstract)] |
|- | |- | ||
| − | | || [[BrainRegionFAM_FD_LHB_MED|FAM.FD.LHB.MED]] || Lateral Habenula Medial Part || modulatory-ne || [http://www.nature.com/nrn/journal/v11/n6/fig_tab/nrn2849_F7.html Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> LHB, abstract)] | + | | || [[BrainRegionFAM_FD_LHB_MED|FAM.FD.LHB.MED]] || Lateral Habenula Medial Part || modulatory-ne || uncertain || [http://www.nature.com/nrn/journal/v11/n6/fig_tab/nrn2849_F7.html Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> LHB, abstract)] |
|- | |- | ||
| − | | || [[BrainRegionFAM_FD_MHB|FAM.FD.MHB]] || Medial Habenula || modulatory-ne || [http://www.nature.com/nrn/journal/v11/n6/fig_tab/nrn2849_F7.html Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> MHB)] | + | | || [[BrainRegionFAM_FD_MHB|FAM.FD.MHB]] || Medial Habenula || modulatory-ne || uncertain || [http://www.nature.com/nrn/journal/v11/n6/fig_tab/nrn2849_F7.html Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> MHB)] |
|- | |- | ||
| − | | || [[BrainRegionFAM_FT_SEP_DBB|FAM.FT.SEP.DBB]] || Diagonal Band of Broca || modulatory-ne || (unknown reference) | + | | || [[BrainRegionFAM_FT_SEP_DBB|FAM.FT.SEP.DBB]] || Diagonal Band of Broca || modulatory-ne || uncertain || (unknown reference) |
|- | |- | ||
| − | | [[BrainAreaFEC|FEC]] || [[BrainRegionFEC_FT_SNC_MED|FEC.FT.SNC.MED]] || Substantia Nigra Pars Compacta Medial || modulatory-ne || (unknown reference) | + | | [[BrainAreaFEC|FEC]] || [[BrainRegionFEC_FT_SNC_MED|FEC.FT.SNC.MED]] || Substantia Nigra Pars Compacta Medial || modulatory-ne || uncertain || (unknown reference) |
|- | |- | ||
| − | | || [[BrainRegionFEC_HT_TG_IPD|FEC.HT.TG.IPD]] || Interpeduncular Nucleus || modulatory-ne || [http://www.nature.com/nrn/journal/v11/n6/fig_tab/nrn2849_F7.html Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> IPN)] | + | | || [[BrainRegionFEC_HT_TG_IPD|FEC.HT.TG.IPD]] || Interpeduncular Nucleus || modulatory-ne || uncertain || [http://www.nature.com/nrn/journal/v11/n6/fig_tab/nrn2849_F7.html Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> IPN)] |
|- | |- | ||
| − | | [[BrainAreaLAC|LAC]] || [[BrainRegionLAC_FD_HT_VLPO|LAC.FD.HT.VLPO]] || Ventrolateral Preoptic Nucleus || modulatory-ne || [http://www.nature.com/neuro/journal/v5/n10/fig_tab/nn913_F1.html Simplified NREM sleep-promoting pathway (LC -> VLPO)] | + | | [[BrainAreaLAC|LAC]] || [[BrainRegionLAC_FD_HT_VLPO|LAC.FD.HT.VLPO]] || Ventrolateral Preoptic Nucleus || modulatory-ne || uncertain || [http://www.nature.com/neuro/journal/v5/n10/fig_tab/nn913_F1.html Simplified NREM sleep-promoting pathway (LC -> VLPO)] |
|- | |- | ||
| − | | || [[BrainRegionLAC_SC_IZ_CSC|LAC.SC.IZ.CSC]] || Ciliospinal Center || modulatory-ne || [http://journal.frontiersin.org/article/10.3389/fnint.2012.00094/full Effect of light on pupil diameter (LC -> IML)] | + | | || [[BrainRegionLAC_SC_IZ_CSC|LAC.SC.IZ.CSC]] || Ciliospinal Center || modulatory-ne || uncertain || [http://journal.frontiersin.org/article/10.3389/fnint.2012.00094/full Effect of light on pupil diameter (LC -> IML)] |
|- | |- | ||
| − | | || [[BrainRegionLAC_SC_IZ_IML|LAC.SC.IZ.IML]] || Intermediolateral Nucleus || modulatory-ne || [http://www.intechopen.com/books/computational-intelligence-in-electromyography-analysis-a-perspective-on-current-applications-and-future-challenges/sphincter-emg-for-diagnosing-multiple-system-atrophy-and-related-disorders Physiology and pathophysiology of lower urinary tract (LC -> IML)] | + | | || [[BrainRegionLAC_SC_IZ_IML|LAC.SC.IZ.IML]] || Intermediolateral Nucleus || modulatory-ne || uncertain || [http://www.intechopen.com/books/computational-intelligence-in-electromyography-analysis-a-perspective-on-current-applications-and-future-challenges/sphincter-emg-for-diagnosing-multiple-system-atrophy-and-related-disorders Physiology and pathophysiology of lower urinary tract (LC -> IML)] |
|} | |} | ||
Latest revision as of 18:29, 28 April 2019
Locus Coeruleus
@@Home -> BiologicalLifeResearch -> BrainAreaLMC -> BrainRegionLMC_HT_LC
This page covers biological details of component Locus Coeruleus. Region is part of aHuman target integrated biological model.
- Top-down path to region: Hindbrain Metencephalon -> Locus Coeruleus (LMC.HT.LC) (see Mind Maps)
- Type: nucleus
- Quality: L0
- Brain area: Lower Brain - Modulatory Contol Area (LMC)
- Area circuit: Norepinephrine - Vigilant Concentration, Stress Hormone, Fight-or-Flight Response (NE)
- Role: processor.autonomic
- Function: Regulate the intensity of responses to salient stimuli, arousal and autonomic activity
- Notes to function:
- NE Source, enhance signal-to-noise ratio, suppressing irrelevant stimuli (lateral inhibition)
- inhibitory nucleus
- wakefulness-promoting nucleus, enhancement of alertness, increase in sympathetic activity and a decrease in parasympathetic activity, to all neocortex, medial septal area, medial preoptic area and substantia innominata, central and basal amygdala, dorsal thalamus
(generated)
Components
(generated)
- no child items defined
Connectivity
(generated)
Inbound Region Connections:
| Source Area | Source Region | Source Name | Type | Role | Reference |
| FAM | FAM.FT.AM.CEM | Medial Central Amygdaloid Nucleus | excitatory-glu | uncertain | Amygdalar disruption of prefrontal cortex (AM -> LC, abstract) |
| FAM.FT.BNST | Bed Nucleus of Stria Terminalis | excitatory-glu | uncertain | (unknown reference) | |
| LAC | LAC.FD.HT.DM | Dorsomedial Hypothalamic Nucleus | excitatory-glu | uncertain | Effect of light on pupil diameter (DMH -> LC) |
| LAC.FD.HT.TBM | Tuberomammillary Nucleus | excitatory-glu | uncertain | (unknown reference) | |
| LRC | LRC.HL.RF.MED | Central Medullary Reticular Nucleus | excitatory-glu | uncertain | (unknown reference) |
| NDM | NDM.NC.AL.VACG | Ventral Anterior Cingulate Area | excitatory-glu | uncertain | (unknown reference) |
Outbound Region Connections:
Thirdparty Circuits
(generated)
- Effect of light on pupil diameter - see Reference (CP.PUPIL-REFLEX)
DMH=Dorsomedial Hypothalamic Nucleus,LAC.FD.HT.DM EW=Edinger-Westphal Nucleus,LAC.MM.EWN EYE=Eye,TARGET.TSA.EYE GC=Ciliary Ganglion,LAC.PN.PSYM.CLG IML=Ciliospinal Center,LAC.SC.IZ.CSC LC=Locus Coeruleus,LMC.HT.LC OPN=Pretectal Olivary Nucleus,LRC.MM.PT.PON PVN=Paraventricular Nucleus,LAC.FD.HT.PV RET=Retinal Nucleus,LPC.FD.RT SCG=Superior Cervical Ganglion,LAC.PN.SYM.SCG SCN=Suprachiasmatic Nucleus,LAC.FD.HT.SCN
- Physiology and pathophysiology of lower urinary tract - see Reference (CM.ONUF)
CN=Caudate Nucleus,FEC.FT.CN (see Basal Ganglia) DVM=Vagus Nucleus,LAC.HL.VGN IMG=Inferior Mesenteric Ganglion,LAC.PN.SYM.IMG IML=Intermediolateral Nucleus,LAC.SC.IZ.IML LC=Locus Coeruleus,LMC.HT.LC MPFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex) MPOA=Median Preoptic Nucleus,LAC.FD.HT.MPO NBM=Basal Nucleus of Meynert,LMC.FT.NBM ONF=Onuf's Nucleus,LPC.SC.VH.ONF PBN=Parabrachial Nucleus,LPC.HT.PRF.PB PEL=Pelvic Peripheral Ganglion,LAC.PN.PSYM.PPG PU=Dorsal Putamen Lateral,FEC.FT.PU.LT PVN=Paraventricular Nucleus,LAC.FD.HT.PV SNC=Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT SPS=Sacral Parasympathetic Nucleus,LAC.SC.IZ.SPS VTA=Ventral Tegmental Area,LMC.MM.VTA ZI=Subthalamic Nucleus Caudal,BGA.FD.STN.ZI
- Contribution of nAChR subunits to nicotine withdrawal symptoms - see Reference (CF.HB-NICOTINE)
IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD LC=Locus Coeruleus,LMC.HT.LC LHB=Lateral Habenula,FAM.FD.LHB (see Habenula) MHB=Medial Habenula,FAM.FD.MHB
- Simplified NREM sleep-promoting pathway - see Reference (CL.TBM-PO)
LC=Locus Coeruleus,LMC.HT.LC LDTg=Laterodorsal Tegmental Nucleus,LMC.HT.TG.LDT TMN=Tuberomammillary Nucleus,LAC.FD.HT.TBM VLPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO
- Amygdalar disruption of prefrontal cortex - see Reference (CF.AM-DISRUPTION)
ACG=Anterior Cingulate Cortex,NC.AL.ACG (see Anterior Cingulate Area) AM=Amygdala,FAM.FT.AM HC=Hippocampus,FMM.FT.HC (see Hippocampal Formation) HT.L=Lateral Hypothalamic Area,LAC.FD.HT.LT (see Hypothalamus) HT.PV=Paraventricular Nucleus,LAC.FD.HT.PV INS=Insular Cortex,NC.INS LC=Locus Coeruleus,LMC.HT.LC MPFC=Orbitofrontal Cortex,NC.AL.OPFC (see Orbitomedial Prefrontal Cortex) PAG=Periaqueductal Gray Matter,LMC.MM.PAG PB=Parabrachial Nucleus,LPC.HT.PRF.PB PUT=Endocrine Glands,TARGET.TEA.ENDOCRINE SOL=Solitary Nucleus,LPC.HL.SOL TH=Thalamus,FD.TH
References
(generated)
- http://journal.frontiersin.org/article/10.3389/fnint.2012.00094/full
- http://www.intechopen.com/books/computational-intelligence-in-electromyography-analysis-a-perspective-on-current-applications-and-future-challenges/sphincter-emg-for-diagnosing-multiple-system-atrophy-and-related-disorders
- http://www.nature.com/nrn/journal/v11/n6/fig_tab/nrn2849_F7.html
- http://www.nature.com/neuro/journal/v5/n10/fig_tab/nn913_F1.html
- http://neuropolitics.org/defaultmay10.asp
