Difference between revisions of "BrainRegionLAC FD HT VLPO"
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* '''Top-down path to region''': Forebrain Diencephalon -> [[BrainCenterFD_HT|Hypothalamus]] (FD.HT) -> Anterior Hypothalamus Area (LAC.FD.HT.AHT) -> Chiasmatic Area (LAC.FD.HT.CHS) -> Preoptic Nucleus (LAC.FD.HT.PO) -> [[BrainRegionLAC_FD_HT_VLPO|Ventrolateral Preoptic Nucleus]] (LAC.FD.HT.VLPO) (see [[OverallMindMaps|Mind Maps]]) | * '''Top-down path to region''': Forebrain Diencephalon -> [[BrainCenterFD_HT|Hypothalamus]] (FD.HT) -> Anterior Hypothalamus Area (LAC.FD.HT.AHT) -> Chiasmatic Area (LAC.FD.HT.CHS) -> Preoptic Nucleus (LAC.FD.HT.PO) -> [[BrainRegionLAC_FD_HT_VLPO|Ventrolateral Preoptic Nucleus]] (LAC.FD.HT.VLPO) (see [[OverallMindMaps|Mind Maps]]) | ||
* '''Type''': nucleus | * '''Type''': nucleus | ||
| − | * '''Brain area''': [[BrainAreaLAC|Lower Brain - Autonomous Control Area]] | + | * '''Quality''': L0 |
| + | * '''Brain area''': [[BrainAreaLAC|Lower Brain - Autonomous Control Area]] (LAC) | ||
| + | * '''Area circuit''': Autonomic Thermoregulation (LAT) | ||
* '''Role''': processor.autonomic | * '''Role''': processor.autonomic | ||
* '''Function''': mediates non-REM sleep onset | * '''Function''': mediates non-REM sleep onset | ||
| Line 29: | Line 31: | ||
{| class=wikitable width=80% | {| class=wikitable width=80% | ||
| − | | '''Source Area''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Reference''' | + | | '''Source Area''' || '''Source Region''' || '''Source Name''' || '''Type''' || '''Role''' || '''Reference''' |
|- | |- | ||
| − | | [[BrainAreaFAM|FAM]] || [[BrainRegionFAM_FT_AM_MEA|FAM.FT.AM.MEA]] || Medial Anterior Amygdaloid Nucleus || excitatory-glu || [http://www.pnas.org/content/107/40/17071/F1.expansion.html Role for serotonin in moral behavior (AMY -> HYP, abstract)] | + | | [[BrainAreaFAM|FAM]] || [[BrainRegionFAM_FT_AM_MEA|FAM.FT.AM.MEA]] || Medial Anterior Amygdaloid Nucleus || excitatory-glu || uncertain ||[http://www.pnas.org/content/107/40/17071/F1.expansion.html Role for serotonin in moral behavior (AMY -> HYP, abstract)] |
|- | |- | ||
| − | | || [[BrainRegionFAM_FT_SEP_LT|FAM.FT.SEP.LT]] || Lateral Septal Nucleus || inhibitory-gaba || [http://www.thebrainlabs.com Cingulate Gyrus (SEP -> HT, abstract)] | + | | || [[BrainRegionFAM_FT_SEP_LT|FAM.FT.SEP.LT]] || Lateral Septal Nucleus || inhibitory-gaba || uncertain ||[http://www.thebrainlabs.com Cingulate Gyrus (SEP -> HT, abstract)] |
|- | |- | ||
| − | | [[BrainAreaFEC|FEC]] || [[BrainRegionFEC_HT_TG_RMTG|FEC.HT.TG.RMTG]] || Rostromedial Tegmental Nucleus || inhibitory-gaba || (unknown reference) | + | | [[BrainAreaFEC|FEC]] || [[BrainRegionFEC_HT_TG_RMTG|FEC.HT.TG.RMTG]] || Rostromedial Tegmental Nucleus || inhibitory-gaba || uncertain ||(unknown reference) |
|- | |- | ||
| − | | [[BrainAreaLAC|LAC]] || [[BrainRegionLAC_FD_HT_DM|LAC.FD.HT.DM]] || Dorsomedial Hypothalamic Nucleus || excitatory-glu || [http://www.dana.org/Publications/ReportDetails.aspx?id=44217 Eating and sleeping to survive (DMH -> VLPO)] | + | | [[BrainAreaLAC|LAC]] || [[BrainRegionLAC_FD_HT_DM|LAC.FD.HT.DM]] || Dorsomedial Hypothalamic Nucleus || excitatory-glu || uncertain ||[http://www.dana.org/Publications/ReportDetails.aspx?id=44217 Eating and sleeping to survive (DMH -> VLPO)] |
|- | |- | ||
| − | | || [[BrainRegionLAC_FD_HT_SCN|LAC.FD.HT.SCN]] || Suprachiasmatic Nucleus || excitatory-glu || (unknown reference) | + | | || [[BrainRegionLAC_FD_HT_SCN|LAC.FD.HT.SCN]] || Suprachiasmatic Nucleus || excitatory-glu || uncertain ||(unknown reference) |
|- | |- | ||
| − | | || [[BrainRegionLAC_FD_HT_TBM|LAC.FD.HT.TBM]] || Tuberomammillary Nucleus || | + | | || [[BrainRegionLAC_FD_HT_TBM|LAC.FD.HT.TBM]] || Tuberomammillary Nucleus || modulatory-hist || modulator ||[http://www.nature.com/neuro/journal/v5/n10/fig_tab/nn913_F1.html Simplified NREM sleep-promoting pathway (TMN -> VLPO)] |
|- | |- | ||
| − | | || [[BrainRegionLAC_FD_HT_VM|LAC.FD.HT.VM]] || Ventromedial Hypothalamic Nucleus || excitatory-glu || (unknown reference) | + | | || [[BrainRegionLAC_FD_HT_VM|LAC.FD.HT.VM]] || Ventromedial Hypothalamic Nucleus || excitatory-glu || uncertain ||(unknown reference) |
|- | |- | ||
| − | | [[BrainAreaLMC|LMC]] || [[BrainRegionLMC_HT_LC|LMC.HT.LC]] || Locus Coeruleus || modulatory-ne || [http://www.nature.com/neuro/journal/v5/n10/fig_tab/nn913_F1.html Simplified NREM sleep-promoting pathway (LC -> VLPO)] | + | | [[BrainAreaLMC|LMC]] || [[BrainRegionLMC_HT_LC|LMC.HT.LC]] || Locus Coeruleus || modulatory-ne || uncertain ||[http://www.nature.com/neuro/journal/v5/n10/fig_tab/nn913_F1.html Simplified NREM sleep-promoting pathway (LC -> VLPO)] |
|- | |- | ||
| − | | [[BrainAreaNSA|NSA]] || [[BrainRegionNSA_NC_PH_PRP|NSA.NC.PH.PRP]] || Prepyriform Cortex || excitatory-glu || (unknown reference) | + | | [[BrainAreaNSA|NSA]] || [[BrainRegionNSA_NC_PH_PRP|NSA.NC.PH.PRP]] || Prepyriform Cortex || excitatory-glu || uncertain ||(unknown reference) |
|} | |} | ||
| Line 53: | Line 55: | ||
{| class=wikitable width=80% | {| class=wikitable width=80% | ||
| − | | '''Target Area''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Reference''' | + | | '''Target Area''' || '''Target Region''' || '''Target Name''' || '''Type''' || '''Role''' || '''Reference''' |
|- | |- | ||
| − | | [[BrainAreaFAM|FAM]] || [[BrainRegionFAM_FD_LHB_LT|FAM.FD.LHB.LT]] || Lateral Habenula Lateral Part || excitatory-glu || [http://www.scholarpedia.org/article/Habenula Habenula Connections (LPO -> LHb, abstract)] | + | | [[BrainAreaFAM|FAM]] || [[BrainRegionFAM_FD_LHB_LT|FAM.FD.LHB.LT]] || Lateral Habenula Lateral Part || excitatory-glu || uncertain || [http://www.scholarpedia.org/article/Habenula Habenula Connections (LPO -> LHb, abstract)] |
|- | |- | ||
| − | | || [[BrainRegionFAM_FD_LHB_MED|FAM.FD.LHB.MED]] || Lateral Habenula Medial Part || excitatory-glu || [http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (LPO -> LHbM)] | + | | || [[BrainRegionFAM_FD_LHB_MED|FAM.FD.LHB.MED]] || Lateral Habenula Medial Part || excitatory-glu || uncertain || [http://www.nature.com/neuro/journal/v17/n9/fig_tab/nn.3779_F2.html Both LHb and MHb control the dopaminergic and serotonergic systems (LPO -> LHbM)] |
|- | |- | ||
| − | | [[BrainAreaLAC|LAC]] || [[BrainRegionLAC_FD_HT_SUM|LAC.FD.HT.SUM]] || Supramammillary Nucleus || excitatory-glu || (unknown reference) | + | | [[BrainAreaLAC|LAC]] || [[BrainRegionLAC_FD_HT_SUM|LAC.FD.HT.SUM]] || Supramammillary Nucleus || excitatory-glu || uncertain || (unknown reference) |
|- | |- | ||
| − | | [[BrainAreaLMC|LMC]] || [[BrainRegionLMC_HT_TG_LDT|LMC.HT.TG.LDT]] || Laterodorsal Tegmental Nucleus || excitatory-glu || [http://www.nature.com/neuro/journal/v5/n10/fig_tab/nn913_F1.html Simplified NREM sleep-promoting pathway (VLPO -> LDTg)] | + | | [[BrainAreaLMC|LMC]] || [[BrainRegionLMC_HT_TG_LDT|LMC.HT.TG.LDT]] || Laterodorsal Tegmental Nucleus || excitatory-glu || uncertain || [http://www.nature.com/neuro/journal/v5/n10/fig_tab/nn913_F1.html Simplified NREM sleep-promoting pathway (VLPO -> LDTg)] |
|} | |} | ||
Latest revision as of 23:19, 29 April 2019
Ventrolateral Preoptic Nucleus
@@Home -> BiologicalLifeResearch -> BrainAreaLAC -> BrainRegionLAC_FD_HT_VLPO
This page covers biological details of component Ventrolateral Preoptic Nucleus. Region is part of aHuman target integrated biological model.
- Top-down path to region: Forebrain Diencephalon -> Hypothalamus (FD.HT) -> Anterior Hypothalamus Area (LAC.FD.HT.AHT) -> Chiasmatic Area (LAC.FD.HT.CHS) -> Preoptic Nucleus (LAC.FD.HT.PO) -> Ventrolateral Preoptic Nucleus (LAC.FD.HT.VLPO) (see Mind Maps)
- Type: nucleus
- Quality: L0
- Brain area: Lower Brain - Autonomous Control Area (LAC)
- Area circuit: Autonomic Thermoregulation (LAT)
- Role: processor.autonomic
- Function: mediates non-REM sleep onset
- Notes to function:
- lesions in VLPO result in insomnia
(generated)
Components
(generated)
- no child items defined
Connectivity
(generated)
Inbound Region Connections:
| Source Area | Source Region | Source Name | Type | Role | Reference |
| FAM | FAM.FT.AM.MEA | Medial Anterior Amygdaloid Nucleus | excitatory-glu | uncertain | Role for serotonin in moral behavior (AMY -> HYP, abstract) |
| FAM.FT.SEP.LT | Lateral Septal Nucleus | inhibitory-gaba | uncertain | Cingulate Gyrus (SEP -> HT, abstract) | |
| FEC | FEC.HT.TG.RMTG | Rostromedial Tegmental Nucleus | inhibitory-gaba | uncertain | (unknown reference) |
| LAC | LAC.FD.HT.DM | Dorsomedial Hypothalamic Nucleus | excitatory-glu | uncertain | Eating and sleeping to survive (DMH -> VLPO) |
| LAC.FD.HT.SCN | Suprachiasmatic Nucleus | excitatory-glu | uncertain | (unknown reference) | |
| LAC.FD.HT.TBM | Tuberomammillary Nucleus | modulatory-hist | modulator | Simplified NREM sleep-promoting pathway (TMN -> VLPO) | |
| LAC.FD.HT.VM | Ventromedial Hypothalamic Nucleus | excitatory-glu | uncertain | (unknown reference) | |
| LMC | LMC.HT.LC | Locus Coeruleus | modulatory-ne | uncertain | Simplified NREM sleep-promoting pathway (LC -> VLPO) |
| NSA | NSA.NC.PH.PRP | Prepyriform Cortex | excitatory-glu | uncertain | (unknown reference) |
Outbound Region Connections:
| Target Area | Target Region | Target Name | Type | Role | Reference |
| FAM | FAM.FD.LHB.LT | Lateral Habenula Lateral Part | excitatory-glu | uncertain | Habenula Connections (LPO -> LHb, abstract) |
| FAM.FD.LHB.MED | Lateral Habenula Medial Part | excitatory-glu | uncertain | Both LHb and MHb control the dopaminergic and serotonergic systems (LPO -> LHbM) | |
| LAC | LAC.FD.HT.SUM | Supramammillary Nucleus | excitatory-glu | uncertain | (unknown reference) |
| LMC | LMC.HT.TG.LDT | Laterodorsal Tegmental Nucleus | excitatory-glu | uncertain | Simplified NREM sleep-promoting pathway (VLPO -> LDTg) |
Thirdparty Circuits
(generated)
- Simplified NREM sleep-promoting pathway - see Reference (CL.TBM-PO)
LC=Locus Coeruleus,LMC.HT.LC LDTg=Laterodorsal Tegmental Nucleus,LMC.HT.TG.LDT TMN=Tuberomammillary Nucleus,LAC.FD.HT.TBM VLPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO
- Both LHb and MHb control the dopaminergic and serotonergic systems - see Reference (CF.HB-DA5HT)
DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB DRN=Dorsal Raphe Nucleus,LMC.MM.RP.DRN GPb=Dorsal Pallidum,FEC.FT.DP (see Basal Ganglia) IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN LHbL=Lateral Habenula Lateral Part,FAM.FD.LHB.LT LHbM=Lateral Habenula Medial Part,FAM.FD.LHB.MED LPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO LS=Lateral Septal Nucleus,FAM.FT.SEP.LT MHb=Medial Habenula,FAM.FD.MHB MRN=Raphe Nuclei of Medulla,LMC.HL.RP (see Medullary Reticular Formation) MS=Medial Septal Nucleus,FAM.FT.SEP.MED PS=Posterior Septal Group,FAM.FT.SEP.PG (see Septal Nuclei) RMTg=Rostromedial Tegmental Nucleus,FEC.HT.TG.RMTG SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (see Basal Ganglia) VP=Ventral Pallidum,FEC.FT.VP (see Basal Ganglia) VTA=Ventral Tegmental Area,LMC.MM.VTA
- Habenula Connections - see Reference (CF.HB-CONNECTIONS)
CPu=Striatum,FEC.FT.ST (see Basal Ganglia) DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB DR=Dorsal Raphe Nucleus,LMC.MM.RP.DRN GPi=Globus Pallidus Internal,FEC.FT.GPI (see Basal Ganglia) IP=Interpeduncular Nucleus,FEC.HT.TG.IPD LH=Lateral Hypothalamic Area,LAC.FD.HT.LT (see Hypothalamus) LHb=Lateral Habenula,FAM.FD.LHB (see Habenula) LPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO MHb=Medial Habenula,FAM.FD.MHB MR=Superior Central Raphe Nucleus,LMC.MM.RP.SUC PB=Endocrine Glands,TARGET.TEA.ENDOCRINE S=Septal Nuclei,FAM.FT.SEP SNc=Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT VTA=Ventral Tegmental Area,LMC.MM.VTA
- Eating and sleeping to survive - see Reference (CP.DMH-CYCLES)
ARC=Arcuate Nucleus of Hypothalamus,LAC.FD.HT.AR DMH=Dorsomedial Hypothalamic Nucleus,LAC.FD.HT.DM LHA=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN MPO=Median Preoptic Nucleus,LAC.FD.HT.MPO PVH=Paraventricular Nucleus,LAC.FD.HT.PV SCN=Suprachiasmatic Nucleus,LAC.FD.HT.SCN VLPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO VMH=Ventromedial Hypothalamic Nucleus,LAC.FD.HT.VM
References
(generated)
