Medial Habenula

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This page covers biological details of component Medial Habenula. Region is part of aHuman target integrated biological model.

Top-down path to region: Forebrain Diencephalon -> Habenula (FAM.FD.HB) -> Medial Habenula (FAM.FD.MHB) (see Mind Maps)
Type: nucleus
Brain area: Forebrain - Affective Motivations Area
Role: processor.affective
Function: Encoding negative feedback, indirect
Notes to function: affects VTA, dorsal raphe but via interpeduncular nucleus

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Components

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Connectivity

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FAM.FD.MHB.dot.png

Inbound Region Connections:

Source Area	Source Region	Source Name	Type	Reference
FAM	FAM.FT.SEP.BAC	Bed Nucleus of Anterior Commissure	excitatory-glu	Connectivity map of the habenula (Septum -> M, abstract)
	FAM.FT.SEP.DBB	Diagonal Band of Broca	inhibitory-gaba	Habenula Connections (DBB -> MHb)
	FAM.FT.SEP.MED	Medial Septal Nucleus	modulatory-ach	Both LHb and MHb control the dopaminergic and serotonergic systems (MS -> MHb)
	FAM.FT.SEP.SF	Septofimbrial Nucleus	inhibitory-gaba	Connectivity map of the habenula (Septum -> M, abstract)
	FAM.FT.SEP.TR	Triangular Septal Nucleus	inhibitory-gaba	Connectivity map of the habenula (Septum -> M, abstract)
FEC	FEC.FT.ACC.SH	Nucleus Accumbens Shell	inhibitory-gaba	Connectivity map of the habenula (NAc -> M, abstract)
LMC	LMC.HT.LC	Locus Coeruleus	modulatory-ne	Contribution of nAChR subunits to nicotine withdrawal symptoms (LC -> MHB)

Outbound Region Connections:

Target Area	Target Region	Target Name	Type	Reference
FAM	FAM.FD.LHB.MED	Lateral Habenula Medial Part	excitatory-glu	Connectivity map of the habenula (M -> L, abstract)
FEC	FEC.HT.TG.IPD	Interpeduncular Nucleus	excitatory-glu	Connectivity map of the habenula (M -> IPN)
TEA	TARGET.TEA.ENDOCRINE	Endocrine Glands	endocrine-pineal-gland	Habenula Connections (MHb -> PB)

Thirdparty Circuits

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Habenula Connections - see Reference

map: CPu=Striatum,FEC.FT.ST (Nucleus Accumbens Core (FEC.FT.ACC.CORE), Nucleus Accumbens Shell (FEC.FT.ACC.SH), Ventral Putamen (FEC.FT.PU.VT), Caudate Nucleus Head (FEC.FT.CN.HD), Caudate Nucleus Body (FEC.FT.CN.BD), Caudate Nucleus Tail (FEC.FT.CN.TL), Dorsal Putamen Lateral (FEC.FT.PU.LT), Dorsal Putamen Medial (FEC.FT.PU.MED)), DBB=Diagonal Band of Broca,FAM.FT.SEP.DBB, DR=Dorsal Raphe Nucleus,LMC.MM.RP.DRN, GPi=Globus Pallidus Internal,FEC.FT.GPI (Globus Pallidus Internal Lateral (FEC.FT.GPI.LT), Globus Pallidus Internal Medial (FEC.FT.GPI.MED), Globus Pallidus Internal Dorsal (FEC.FT.GPI.DS), Globus Pallidus Internal Rostromedial (FEC.FT.GPI.RM), Globus Pallidus Internal Dorsolateral (FEC.FT.GPI.DL)), IP=Interpeduncular Nucleus,FEC.HT.TG.IPD, LH=Lateral Hypothalamic Area,LAC.FD.HT.LT (Lateral Hypothalamic Nucleus (LAC.FD.HT.LTN), Supramammillary Nucleus (LAC.FD.HT.SUM), Tuberomammillary Nucleus (LAC.FD.HT.TBM), Premammillary Nucleus (LAC.FD.HT.PRM)), LHb=Lateral Habenula,FAM.FD.LHB (Lateral Habenula Medial Part (FAM.FD.LHB.MED), Lateral Habenula Lateral Part (FAM.FD.LHB.LT)), LPO=Ventrolateral Preoptic Nucleus,LAC.FD.HT.VLPO, MHb=Medial Habenula,FAM.FD.MHB, MR=Superior Central Raphe Nucleus,LMC.MM.RP.SUC, PB=Endocrine Glands,TARGET.TEA.ENDOCRINE, S=Septal Nuclei,FAM.FT.SEP, SNc=Substantia Nigra Pars Compacta Lateral,FEC.FT.SNC.LT, VTA=Ventral Tegmental Area,LMC.MM.VTA unavailable

Connectivity map of the habenula - see Reference

map: CPu=Striatum,FEC.FT.ST (Nucleus Accumbens Core (FEC.FT.ACC.CORE), Nucleus Accumbens Shell (FEC.FT.ACC.SH), Ventral Putamen (FEC.FT.PU.VT), Caudate Nucleus Head (FEC.FT.CN.HD), Caudate Nucleus Body (FEC.FT.CN.BD), Caudate Nucleus Tail (FEC.FT.CN.TL), Dorsal Putamen Lateral (FEC.FT.PU.LT), Dorsal Putamen Medial (FEC.FT.PU.MED)), EP=Endopiriform Nucleus,FAM.FT.EPF, Hippo=Hippocampus,FMM.FT.HC (Dentate Gyrus (FMM.FT.HC.DG), Proximal CA1 of Hippocampus (FMM.FT.HC.CA1P), Middle CA1 of Hippocampus (FMM.FT.HC.CA1M), Distal CA1 of Hippocampus (FMM.FT.HC.CA1D), Dorsolateral Cornu Ammonis of Hippocampus (FMM.FT.HC.CA2), Proximal CA3 of Hippocampus (FMM.FT.HC.CA3P), Middle CA3 of Hippocampus (FMM.FT.HC.CA3M), Distal CA3 of Hippocampus (FMM.FT.HC.CA3D)), IPN=Interpeduncular Nucleus,FEC.HT.TG.IPD, L=Lateral Habenula,FAM.FD.LHB (Lateral Habenula Medial Part (FAM.FD.LHB.MED), Lateral Habenula Lateral Part (FAM.FD.LHB.LT)), LH=Lateral Hypothalamic Nucleus,LAC.FD.HT.LTN, M=Medial Habenula,FAM.FD.MHB, NAc=Accumbens Nucleus,FEC.FT.ACC (Nucleus Accumbens Core (FEC.FT.ACC.CORE), Nucleus Accumbens Shell (FEC.FT.ACC.SH)), PAG=Periaqueductal Gray Matter,LMC.MM.PAG, Raphe=Raphe Nuclei of Medulla,LMC.HL.RP (Raphe Pallidus Nucleus (LMC.HL.RP.PL), Raphe Obscurus Nucleus (LMC.HL.RP.OB), Raphe Magnus Nucleus (LMC.HL.RP.MG)), SNc=Substantia Nigra Pars Compacta,FEC.FT.SNC (Substantia Nigra Pars Compacta Lateral (FEC.FT.SNC.LT), Substantia Nigra Pars Compacta Medial (FEC.FT.SNC.MED)), Septum=Septal Nuclei,FAM.FT.SEP, VTA=Ventral Tegmental Area,LMC.MM.VTA unavailable

Exploring role of habenula in emotional behaviors - see Reference

map: LHb=Lateral Habenula,FAM.FD.LHB (Lateral Habenula Medial Part (FAM.FD.LHB.MED), Lateral Habenula Lateral Part (FAM.FD.LHB.LT)), MHb=Medial Habenula,FAM.FD.MHB unavailable